https://luck.synhera.be/handle/123456789/66 2026-04-17T17:14:34Z https://luck.synhera.be/handle/123456789/3105 Effect of Oral Versus Nasal Breathing on Muscular Performance, Muscle Oxygenation, and Post-Exercise Recovery Morgan Lévénez; Clément Lévêque; Capucine Lafère; François Guerrero; Costantino Balestra; Pierre Lafère Nitric oxide (NO) plays a crucial role in muscle oxidative capacity, which predicts muscle strength. This study aimed to investigate whether different breathing techniques (nasal or oral breathing) affect muscle performance during acute exhaustive exercise. In our study, 49 healthy individuals (24female symbol/25male symbol; age 22.8 +/- 3.4 years) performed two Wingate anaerobic tests in a counterbalanced order. Although perceived exertion was significantly higher with oral breathing (Borg Scale: 9.0 +/- 1.1 vs. 8.0 +/- 1.3, p = 0.04), breathing mode did not impact power output (peak: 749 +/- 290 vs. 728 +/- 284 W; average: 576 +/- 217 vs. 575 +/- 216 W, p = 0.2). NIRS data indicated no significant differences in muscle desaturation between the two breathing modes; however, nasal breathing resulted in significantly faster (0.45 +/- 0.4 vs. 0.23 +/- 0.12%/s, p = 0.02) and greater (75.2 +/- 4.0 vs. 73.1 +/- 3.6%, p = 0.04) post-exercise muscle recovery. As an indirect marker of NO bioavailability, flow-mediated dilation (FMD) was associated with a significant improvement (Pre: 107.4 +/- 3.0% vs. Post: 110.3 +/- 3.6%, p < 0.001) via nasal breathing only, with a significant difference between the two breathing modes (p < 0.0001). Therefore, we suggest that the nitrate-nitrite-NO pathway enhances muscle energy and function, which highlights the importance of nasal breathing. 2025-10-20T00:00:00Z https://luck.synhera.be/handle/123456789/3104 Effect of Oral Versus Nasal Breathing on Muscular Performance, Muscle Oxygenation, and Post-Exercise Recovery Morgan Lévénez; Clément Lévêque; Capucine Lafère; François Guerrero; Costantino Balestra; Pierre Lafère Nitric oxide (NO) plays a crucial role in muscle oxidative capacity, which predicts muscle strength. This study aimed to investigate whether different breathing techniques (nasal or oral breathing) affect muscle performance during acute exhaustive exercise. In our study, 49 healthy individuals (24♀/25♂; age 22.8 3.4 years) performed two Wingate anaerobic tests in a counterbalanced order. Although perceived exertion was significantly higher with oral breathing (Borg Scale: 9.0 1.1 vs. 8.0 1.3, p = 0.04), breathing mode did not impact power output (peak: 749 290 vs. 728 284 W; average: 576 217 vs. 575 216 W, p = 0.2). NIRS data indicated no significant differences in muscle desaturation between the two breathing modes; however, nasal breathing resulted in significantly faster (0.45 0.4 vs. 0.23 0.12%/s, p = 0.02) and greater (75.2 4.0 vs. 73.1 3.6%, p = 0.04) post-exercise muscle recovery. As an indirect marker of NO bioavailability, flow- mediated dilation (FMD) was associated with a significant improvement (Pre: 107.4 3.0% vs. Post: 110.3 3.6%, p < 0.001) via nasal breathing only, with a significant difference between the two breathing modes (p < 0.0001). Therefore, we suggest that the nitrate–nitrite–NO pathway enhances muscle energy and function, which highlights the importance of nasal breathing. 2025-10-20T00:00:00Z https://luck.synhera.be/handle/123456789/3103 Inert Gas Mild Pressure Action on Healthy Humans: The “IPA” Study Costantino Balestra; Clément Leveque; Simona Mrakic-Sposta; Mathias Coulon; Romain Tumbarello; Alessandra Vezzoli; Gerardo Bosco; Zuha Imtiyaz; Stephen R. Thom The goal of this study was to evaluate inflammatory and oxidative stress responses in human subjects (9 females and 15 males) (age [29.6 +/- 11.5 years old (mean +/- SD)], height [172.0 +/- 10.05 cm], and weight [67.8 +/- 12.4 kg]) exposed to 1.45 ATA of helium (He) or nitrogen (N(2)) without concurrent hyperoxia. We hypothesized that elevated gas pressures would elicit an inflammatory response concurrent with oxidative stress. Consistent with ex vivo studies, both gasses elicited neutrophil activation, small elevations in microparticles (MPs) and increases in intra-MP interleukin (IL)-1beta and inflammatory nitric oxide synthase, and an increase in urinary IL-6 concurrent with a marked reduction in plasma gelsolin. Mixed responses indictive of oxidative stress, with some biomarker elevations but little change in others and a decrease in some, were observed. Overall, these results demonstrate that exposure to typical diving gasses at a mildly elevated partial pressure will initiate inflammatory responses, which may play a significant role in decompression sickness (DCS). The complex pattern of oxidative stress responses may be indicative of competing systemic reactions and sampling different body fluids. 2024-11-10T00:00:00Z https://luck.synhera.be/handle/123456789/3065 Inert Gas Mild Pressure Action on Healthy Humans: The “IPA” Study Costantino Balestra; Clément Leveque; Simona Mrakic-Sposta; Mathias Coulon; Romain Tumbarello; Alessandra Vezzoli; Gerardo Bosco; Zuha Imtiyaz; Stephen R. Thom The goal of this study was to evaluate inflammatory and oxidative stress responses in human subjects (9 females and 15 males) (age [29.6 +/- 11.5 years old (mean +/- SD)], height [172.0 +/- 10.05 cm], and weight [67.8 +/- 12.4 kg]) exposed to 1.45 ATA of helium (He) or nitrogen (N(2)) without concurrent hyperoxia. We hypothesized that elevated gas pressures would elicit an inflammatory response concurrent with oxidative stress. Consistent with ex vivo studies, both gasses elicited neutrophil activation, small elevations in microparticles (MPs) and increases in intra-MP interleukin (IL)-1beta and inflammatory nitric oxide synthase, and an increase in urinary IL-6 concurrent with a marked reduction in plasma gelsolin. Mixed responses indictive of oxidative stress, with some biomarker elevations but little change in others and a decrease in some, were observed. Overall, these results demonstrate that exposure to typical diving gasses at a mildly elevated partial pressure will initiate inflammatory responses, which may play a significant role in decompression sickness (DCS). The complex pattern of oxidative stress responses may be indicative of competing systemic reactions and sampling different body fluids. 2024-11-10T00:00:00Z