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Factors influencing the severity of long-term sequelae in fishermen-divers with neurological decompression sickness
31 mars 2020, Blatteau, Jean-Eric; LAMBRECHTS, Kate; Ruffez, Jean,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Introduction: Numerous studies have been conducted to identify the factors influencing the short-term prognosis for neurological decompression sickness (DCS). However, the long-term sequelae are rarely assessed. The purpose of this study to investigate the factors likely to influence the long-term prognosis.
Methods: Twenty-seven Vietnamese fishermen-divers who on average 9 (SD 6) years beforehand ...
Simulated air dives induce superoxide, nitric oxide, peroxynitrite, and Ca 2+ alterations in endothelial cells
03 avril 2019, Wang, Qiong; Guerrero, François; LAMBRECHTS, Kate; Theron, Michaël,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Human diving is known to induce endothelial dysfunction. The aim of this study was to decipher the mechanism of ROS production during diving through the measure of mitochondrial calcium concentration, peroxynitrite, NO°, and superoxide towards better understanding of dive-induced endothelial dysfunction. Air diving simulation using bovine arterial endothelial cells (compression rate 101 kPa/min to ...
Tirofiban, a Glycoprotein IIb/IIIa Antagonist, Has a Protective Effect on Decompression Sickness in Rats: Is the Crosstalk Between Platelet and Leukocytes Essential?
11 juillet 2018, LAMBRECHTS, Kate; Demaistre, Sébastien; Blatteau, Jean-Eric; Risso, Jean-Jacques; Vallée, Nicolas,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
In its severest forms, decompression sickness (DCS) may extend systemically and/or induce severe neurological deficits, including paralysis or even death. It seems that the sterile and ischemic inflammatory phenomena are consecutive to the reaction of the bubbles with the organism and that the blood platelet activation plays a determinant role in the development of DCS. According to the hypotheses ...
Venous gas emboli are involved in post-dive macro, but not microvascular dysfunction
21 janvier 2017, LAMBRECHTS, Kate; BALESTRA, Costantino; Theron, Michaël; Henckes, Anne; Galinat, Hubert; Mignant, Fanny; Belhomme, Marc; Pontier, Jean-Michel; Guerrero, François,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Purpose: Previous studies have shown vascular dysfunction of main conductance arteries and microvessels after diving. We aim to evaluate the impact of bubble formation on vascular function and haemostasis. To achieve this, we used a vibration preconditioning to influence bubble levels without changing any other parameters linked to the dive.
Methods: Twentty-six divers were randomly assigned to ...
Effect of simulated air dive and decompression sickness on the plasma proteome of rats
12 avril 2016, Lautridou, Jacky; Pichereau, Vianney; Artigaud, Sébastien; Buzzacott, Peter; Wang, Qiong; Bernay, Benoit; Driad, Sabrina; Mazur, Aleksandra; LAMBRECHTS, Kate; Theron, Michaël; Guerrero, François,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Purpose: Decompression sickness (DCS) is a poorly understood systemic disease caused by inadequate desaturation following a reduction in ambient pressure. Although recent studies highlight the importance of circulating factors, the available data are still puzzling. In this study, we aimed to identify proteins and biological pathways involved in the development of DCS in rats.
Experimental design: ...
Age, weight and decompression sickness in rats
16 mars 2016, Buzzacott, Peter; Theron, Michaël; Mazur, Aleksandra; Wang, Qiong; LAMBRECHTS, Kate; Eftedal, Ingrid; Berenji, Simin,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Objective: The aim of this study was to determine if, after controlling for weight, age is associated with decompression sickness (DCS) in rats. Methods: Following compression-decompression, male rats aged 11 weeks were observed for DCS. After two weeks recovery, surviving rats were re-dived using the same compression-decompression profile. Results: In this experiment, there was a clear difference ...
Fluoxetine Protection in Decompression Sickness in Mice is Enhanced by Blocking TREK-1 Potassium Channel with the "spadin" Antidepressant
16 février 2016, Vallée, Nicolas; LAMBRECHTS, Kate; De Maistre, Sébastien; Royal, Perrine; Mazella, Jean; Borsotto, Marc; Heurteaux, Catherine; Abraini, Jacques; RIsso, Jean-Jacques; Blatteau, Jean-Eric,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
In mice, disseminated coagulation, inflammation, and ischemia induce neurological damage that can lead to death. These symptoms result from circulating bubbles generated by a pathogenic decompression. Acute fluoxetine treatment or the presence of the TREK-1 potassium channel increases the survival rate when mice are subjected to an experimental dive/decompression protocol. This is a paradox because ...
Colonic Fermentation Promotes Decompression sickness in Rats
08 février 2016, Demaistre, Sébastien; Vallée, Nicolas; Gempp, Emmanuel; LAMBRECHTS, Kate; Louge, Pierre; Duchamp, Claude; Blatteau, Jean-Eric,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Massive bubble formation after diving can lead to decompression sickness (DCS). During dives with hydrogen as a diluent for oxygen, decreasing the body's H2 burden by inoculating hydrogen-metabolizing microbes into the gut reduces the risk of DCS. So we set out to investigate if colonic fermentation leading to endogenous hydrogen production promotes DCS in fasting rats. Four hours before an experimental ...
Fluoxetine stimulates anti-inflammatory IL-10 cytokine production and attenuates sensory deficits in a rat model of decompression sickness
22 octobre 2015, Blatteau, Jean-Eric; De Maistre, Sébastien; LAMBRECHTS, Kate; Abraini, Jacques; Risso, Jean-Jacques; Vallée, Nicolas,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Despite "gold standard" hyperbaric oxygen treatment, 30% of patients suffering from neurological decompression sickness still exhibit incomplete recovery, including sensory impairments. Fluoxetine, a well-known antidepressant, is recognized as having anti-inflammatory effects in the setting of cerebral ischemia. In this study, we focused on the assessment of sensory neurological deficits and measurement ...
Mechanism of action of antiplatelet drugs on decompression sickness in rats: a protective effect of anti-GPIIbIIIa therapy
15 mai 2015, LAMBRECHTS, Kate; Mazur, Aleksandra; Pontier, Jean-Michel; Theron, Michaël; Buzzacott, Peter; Wang, Qiong; Belhomme, Marc; Guerrero, François,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Literature highlights the involvement of disseminated thrombosis in the pathophysiology of decompression sickness (DCS). We examined the effect of several antithrombotic treatments targeting various pathways on DCS outcome: acetyl salicylate, prasugrel, abciximab, and enoxaparin. Rats were randomly assigned to six groups. Groups 1 and 2 were a control nondiving group (C; n = 10) and a control diving ...