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Influence of decompression sickness on vasocontraction of isolated rat vessels![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
18 février 2015, Mazur, Aleksandra; LAMBRECHTS, Kate; Wang, Qiong; Belhomme, Marc; Theron, Michaël; Buzzacott, Peter; Guerrero, François,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Studies conducted in divers indicate that endothelium function is impaired following a dive even without decompression sickness (DCS). Our previous experiment conducted on rat isolated vessels showed no differences in endothelium-dependent vasodilation after a simulated dive even in the presence of DCS, while contractile response to phenylephrine was progressively impaired with increased decompression ...
Increasing Oxygen Partial Pressures Induce a Distinct Transcriptional Response in Human PBMC: A Pilot Study on the “Normobaric Oxygen Paradox”![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
05 janvier 2021, Fratantonio, Deborah; Virgili, Fabio; Zucchi, Alessandro; LAMBRECHTS, Kate; Latronico, Tiziana; Lafère, Pierre; Germonpré, Pierre; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
The term "normobaric oxygen paradox" (NOP), describes the response to the return to normoxia after a hyperoxic event, sensed by tissues as oxygen shortage, and resulting in up-regulation of the Hypoxia-inducible factor 1alpha (HIF-1alpha) transcription factor activity. The molecular characteristics of this response have not been yet fully characterized. Herein, we report the activation time trend ...
Heart Rate Variability During a Standard Dive: A Role for Inspired Oxygen Pressure?![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
13 août 2021, Lafère, Pierre; LAMBRECHTS, Kate; GERMONPRÉ, Peter; Balestra, Ambre; Germonpré, Faye-Lisa; Marroni, Alessandro; Cialoni, Danilo; Bosco, Gerardo; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Introduction: Heart rate variability (HRV) during underwater diving has been infrequently investigated because of environment limitations and technical challenges. This study aims to analyze HRV changes while diving at variable hyperoxia when using open circuit (OC) air diving apparatus or at constant hyperoxia using a closed-circuit rebreather (CCR). We used HRV analysis in time and frequency domain ...
Heart Rate Variability During a Standard Dive: A Role for Inspired Oxygen Pressure?![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
13 août 2021, Lafère, Pierre; LAMBRECHTS, Kate; GERMONPRÉ, Peter; BALESTRA, Ambre; Germonpré, Faye-Lisa; Marroni, Alessandro; Cialoni, Danilo; Bosco, Gerardo; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Introduction: Heart rate variability (HRV) during underwater diving has been infrequently investigated because of environment limitations and technical challenges. This study aims to analyze HRV changes while diving at variable hyperoxia when using open circuit (OC) air diving apparatus or at constant hyperoxia using a closed-circuit rebreather (CCR). We used HRV analysis in time and frequency domain ...
Full-Face Mask Use during SCUBA Diving Counters Related Oxidative Stress and Endothelial Dysfunction![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
15 janvier 2022, Levenez, Morgan; LAMBRECHTS, Kate; Mrakic-Sposta, Simona; Vezzoli, Alessandra; Germonpré, Peter; Pique, Hadrien; Virgili, Fabi; Bosco, Gerardo; Lafere, Pierre; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Impaired flow mediated dilation (FMD), an index of vascular stress, is known after SCUBA diving. This is related to a dysfunction of nitric oxide (NO) availability and a disturbance of the redox status, possibly induced by hyperoxic/hyperbaric gas breathing. SCUBA diving is usually performed with a mask only covering "half face" (HF) and therefore forcing oral breathing. Nasal NO production is ...
Fluoxetine stimulates anti-inflammatory IL-10 cytokine production and attenuates sensory deficits in a rat model of decompression sickness![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
22 octobre 2015, Blatteau, Jean-Eric; De Maistre, Sébastien; LAMBRECHTS, Kate; Abraini, Jacques; Risso, Jean-Jacques; Vallée, Nicolas,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Despite "gold standard" hyperbaric oxygen treatment, 30% of patients suffering from neurological decompression sickness still exhibit incomplete recovery, including sensory impairments. Fluoxetine, a well-known antidepressant, is recognized as having anti-inflammatory effects in the setting of cerebral ischemia. In this study, we focused on the assessment of sensory neurological deficits and measurement ...
Fluoxetine Protection in Decompression Sickness in Mice is Enhanced by Blocking TREK-1 Potassium Channel with the "spadin" Antidepressant![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
16 février 2016, Vallée, Nicolas; LAMBRECHTS, Kate; De Maistre, Sébastien; Royal, Perrine; Mazella, Jean; Borsotto, Marc; Heurteaux, Catherine; Abraini, Jacques; RIsso, Jean-Jacques; Blatteau, Jean-Eric,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
In mice, disseminated coagulation, inflammation, and ischemia induce neurological damage that can lead to death. These symptoms result from circulating bubbles generated by a pathogenic decompression. Acute fluoxetine treatment or the presence of the TREK-1 potassium channel increases the survival rate when mice are subjected to an experimental dive/decompression protocol. This is a paradox because ...
Factors influencing the severity of long-term sequelae in fishermen-divers with neurological decompression sickness![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
31 mars 2020, Blatteau, Jean-Eric; LAMBRECHTS, Kate; Ruffez, Jean,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Introduction: Numerous studies have been conducted to identify the factors influencing the short-term prognosis for neurological decompression sickness (DCS). However, the long-term sequelae are rarely assessed. The purpose of this study to investigate the factors likely to influence the long-term prognosis.
Methods: Twenty-seven Vietnamese fishermen-divers who on average 9 (SD 6) years beforehand ...
Endothelial function may be enhanced in the cutaneous microcirculation after a single air dive![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
30 septembre 2020, Guerrero, François; LAMBRECHTS, Kate; Wang, Qiong; Mazur, Aleksandra; Marroni, Alessandro,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Introduction: The effects of scuba diving on the vessel wall have been studied mainly at the level of large conduit arteries. Data regarding the microcirculation are scarce and indicate that these two vascular beds are affected differently by diving.
Methods: We assessed the changes in cutaneous microcirculation before an air scuba dive, then 30 min and 24 h after surfacing. Endothelium-dependent ...
Effect of splenectomy on platelet activation and decompression sickness outcome in a rat model of decompression![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
01 septembre 2014, LAMBRECHTS, Kate; Pontier, Jean-Michel; Mazur, Aleksandra; Buzzacott, Peter; Goanvec, Christel; Wang, Qiong; Theron, Michaël; Belhomme, Marc; Guerrero, François,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Introduction: Splenic platelets have been recognized to have a greater prothrombotic potential than others platelets. We studied whether platelets released by splenic contraction could influence the severity and outcome of decompression sickness (DCS) and bubble-induced platelet activation.
Methods: Sixteen, male Sprague-Dawley rats were randomly assigned to either a control or a splenectomized ...