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    • The Impact of Inotropes and Vasopressors on Cerebral Oxygenation in Patients with Traumatic Brain Injury and Subarachnoid Hemorrhage: A Narrative ReviewPeer reviewedOpen access 

      24 janvier 2024, Michele Salvagno; Federico Geraldini; Giacomo Coppalini; Chiara Robba; Elisa Gouvea Bogossian; Filippo Annoni; Eva Vitali; Elda Diletta Sterchele; BALESTRA, Costantinoorcid-id; Fabio Silvio Taccone, HE Bruxelles Brabant
      Article scientifique
      Traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH) are critical neurological conditions that necessitate specialized care in the Intensive Care Unit (ICU). Managing cerebral perfusion pressure (CPP) and mean arterial pressure (MAP) is of primary importance in these patients. To maintain targeted MAP and CPP, vasopressors and/or inotropes are commonly used. However, their effects on ...

    • Oxidative Stress and Cerebral Vascular Tone: The Role of Reactive Oxygen and Nitrogen SpeciesPeer reviewedOpen access 

      05 mars 2024, Michele Salvagno; Elda Diletta Sterchele; Mario Zaccarelli; Simona Mrakic-Sposta; Ian James Welsby; BALESTRA, Costantinoorcid-id; Fabio Silvio Taccone, HE Bruxelles Brabant
      Article scientifique
      he brain's unique characteristics make it exceptionally susceptible to oxidative stress, which arises from an imbalance between reactive oxygen species (ROS) production, reactive nitrogen species (RNS) production, and antioxidant defense mechanisms. This review explores the factors contributing to the brain's vascular tone's vulnerability in the presence of oxidative damage, which can be of clinical ...