| dc.rights.license | CC0 | en_US |
| dc.contributor.author | Galleni, Moreno | |
| dc.contributor.author | Franceschini, Nicola | |
| dc.contributor.author | QUINTING, Birgit | |
| dc.contributor.author | Fattorini, Lanfranco | |
| dc.contributor.author | Orefici, Graziella | |
| dc.contributor.author | Oratore, Arduino | |
| dc.contributor.author | Frère, Jean-Marie | |
| dc.contributor.author | Amicosante, Gianfranco | |
| dc.date.accessioned | 2021-09-21T07:49:54Z | |
| dc.date.available | 2021-09-21T07:49:54Z | |
| dc.date.issued | 1994-07 | |
| dc.identifier.issn | 0066-4804 | en_US |
| dc.identifier.uri | https://luck.synhera.be/handle/123456789/1159 | |
| dc.identifier.doi | https://doi.org/10.1128/AAC.38.7.1608 | en_US |
| dc.description.abstract | Vol. 38, No. 7,, p. 1608-1614 | en_US |
| dc.description.abstractfr | Seize composés différents habituellement considérés comme stables ou représentant du potentiel I-lactam inhibiteurs et inactivateurs ont été testés contre la j-lactamase produite par Mycobacterium fortuitum. Le composés présentant les propriétés les plus intéressantes étaient BRL42715, qui était de loin le meilleur inactivateur, et CGP31608 et ceftazidime, qui n’ont pas été reconnus par l’enzyme. Ces propriétés adéquates pour lutter contre les infections mycobactériennes. Bien que cloxacilline, dicloxacilline, cefoxitine, et CP65207-2 a montré une faible efficacité inhibitrice contre l’enzyme, ils étaient également des substrats plutôt pauvres et pourrait être considéré comme des agents antimycobactériens potentiels. En revanche, CGP31523A et ceftamet étaient substrats. | en_US |
| dc.description.abstracten | Sixteen different compounds usually considered j-lactamase stable or representing potential I-lactam inhibitors and inactivators were tested against the j-lactamase produced by Mycobacterium fortuitum. The compounds exhibiting the most interesting properties were BRL42715, which was by far the best inactivator, and CGP31608 and ceftazidime, which were not recognized by the enzyme. These compounds thus exhibited adequate properties for fighting mycobacterial infections. Although cloxacillin, dicloxacillin, cefoxitin, and CP65207-2 exhibited poor inhibitory efficiency against the enzyme, they were also rather poor substrates and might be considered potential antimycobacterial agents. By contrast, CGP31523A and ceftamet were good substrates. | en_US |
| dc.description.sponsorship | OTH | en_US |
| dc.language.iso | EN | en_US |
| dc.publisher | American Society for Microbiology | en_US |
| dc.relation.ispartof | Antimicrobial Agents and Chemotherapy | en_US |
| dc.rights.uri | ? | en_US |
| dc.title | Use of the Chromosomal Class A ,-Lactamase of Mycobacterium fortuitum D316 To Study Potentially Poor Substrates and Inhibitory P-Lactam Compounds | en_US |
| dc.title.fr | Utilisation du bêta-lactamase chromosomique de classe A de Mycobacterium fortuitum D316 pour étudier les substrats potentiellement pauvres et les composés inhibiteurs du bêta-lactame | en_US |
| dc.type | Article scientifique | en_US |
| synhera.classification | Sciences du vivant>>Microbiologie | en_US |
| synhera.institution | Autre | en_US |
| synhera.otherinstitution | Université de Liège, Laboratory of Enzymology, Centre d'Ingénierie des Protéines | en_US |
| synhera.otherinstitution | University of L'Aquila (Italie), Department of Science and Biomedical Technology and Biometrics | en_US |
| synhera.otherinstitution | Istituto Superiore di Sanità (Rome), Laboratory of Bacteriology and Medical Mycology | en_US |
| synhera.stakeholders.fund | ? | en_US |
| synhera.cost.total | ? | en_US |
| synhera.cost.apc | ? | en_US |
| synhera.cost.comp | ? | en_US |
| synhera.cost.acccomp | ? | en_US |
| dc.description.version | Oui | en_US |
| dc.rights.holder | ULiège | en_US |
