Inflammation Promotes a Conversion of Astrocytes into Neural Progenitor Cells via NF-κB Activation
| dc.rights.license | CC6 | en_US |
| dc.contributor.author | Gabel, Sébastien | |
| dc.contributor.author | Koncina, Eric | |
| dc.contributor.author | DORBAN, Gauthier | |
| dc.contributor.author | Heurtaux, Tony | |
| dc.contributor.author | Birck, Cindy | |
| dc.contributor.author | Glaab, Enrico | |
| dc.contributor.author | Michelucci, Alessandro | |
| dc.contributor.author | Heuschling, Paul | |
| dc.contributor.author | Grandbarbe, Luc | |
| dc.date.accessioned | 2020-09-25T12:23:44Z | |
| dc.date.available | 2020-09-25T12:23:44Z | |
| dc.date.issued | 2016-10 | |
| dc.identifier.issn | 0893-7648 | en_US |
| dc.identifier.uri | https://luck.synhera.be/handle/123456789/302 | |
| dc.identifier.doi | 10.1007/s12035-015-9428-3 | en_US |
| dc.description.abstract | Publication traitant de la dédifférenciation des astrocytes dans un environnement inflammatoire | en_US |
| dc.description.abstracten | Brain inflammation, a common feature in neurodegenerative diseases, is a complex series of events, which can be detrimental and even lead to neuronal death. Nonetheless, several studies suggest that inflammatory signals are also positively influencing neural cell proliferation, survival, migration, and differentiation. Recently, correlative studies suggested that astrocytes are able to dedifferentiate upon injury and may thereby re-acquire neural stem cell (NSC) potential. However, the mechanism underlying this dedifferentiation process upon injury remains unclear. Here, we report that during the early response of reactive gliosis, inflammation induces a conversion of mature astrocytes into neural progenitors. A TNF treatment induces the decrease of specific astrocyte markers, such as glial fibrillary acidic protein (GFAP) or genes related to glycogen metabolism, while a subset of these cells re-expresses immaturity markers, such as CD44, Musashi-1, and Oct4. Thus, TNF treatment results in the appearance of cells that exhibit a neural progenitor phenotype and are able to proliferate and differentiate into neurons and/or astrocytes. This dedifferentiation process is maintained as long as TNF is present in the culture medium. In addition, we highlight a role for Oct4 in this process, since the TNF-induced dedifferentiation can be prevented by inhibiting Oct4 expression. Our results show that activation of the NF-κB pathway through TNF plays an important role in the dedifferentiation of astrocytes via the re-expression of Oct4. These findings indicate that the first step of reactive gliosis is in fact a dedifferentiation process of resident astrocytes mediated by the NF-κB pathway. | en_US |
| dc.description.sponsorship | OTH | en_US |
| dc.language.iso | EN | en_US |
| dc.publisher | Springer | en_US |
| dc.relation.ispartof | Molecular Neurobiology | en_US |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | en_US |
| dc.subject | Astrocyte | en_US |
| dc.subject | Inflammation | en_US |
| dc.subject | NF-κB | en_US |
| dc.subject | Neural progenitor cells | en_US |
| dc.subject.en | Astrocyte | en_US |
| dc.subject.en | Inflammation | en_US |
| dc.subject.en | NF-KB | en_US |
| dc.subject.en | Dedifferentiation | en_US |
| dc.subject.en | Neural Progenitor Cells | en_US |
| dc.title | Inflammation Promotes a Conversion of Astrocytes into Neural Progenitor Cells via NF-κB Activation | en_US |
| dc.title.en | Inflammation Promotes a Conversion of Astrocytes into Neural Progenitor Cells via NF-κB Activation | en_US |
| dc.title.fr | L'inflammation induit la transformation des astrocytes en précurseurs neuronaux par l'activation de NF-KB | en_US |
| dc.type | Article scientifique | en_US |
| synhera.classification | Sciences de la santé humaine | en_US |
| synhera.classification | Sciences du vivant | en_US |
| synhera.classification | Sciences de la santé humaine>>Orthopédie, rééducation & médecine sportive | en_US |
| synhera.institution | HE Robert Schuman | en_US |
| synhera.otherinstitution | University of Luxembourg | en_US |
| synhera.cost.total | 0 | en_US |
| synhera.cost.apc | 0 | en_US |
| synhera.cost.comp | 0 | en_US |
| synhera.cost.acccomp | 0 | en_US |
| dc.description.version | Oui | en_US |
| dc.rights.holder | University of Luxembourg | en_US |
Fichier(s) constituant ce document
Ce document figure dans la(les) collection(s) suivante(s)
Excepté là où spécifié autrement, la license de ce document est décrite en tant que CC6