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    • Effect Of Induced Relative Hypoxia On Reticulocyte Count In Oncologycal Abdominal Surgery: A Single-Centre, Controlled, Randomized Pilot Study.Peer reviewedOpen access 

      04 avril 2018, Khalife, Maher; Wiams, Kathleen; Ben Aziz, M; BALESTRA, Costantino; Sosnowski, Maurice, HE Bruxelles Brabant
      Article scientifique
      Erythropoietin (EPO) stimulating agents are known as alternatives to transfusion. However, they expose patients to thrombosis and are expensive. A phenomenon, “the normobaric oxygen paradox” (NOP), has been described. A transient hyperoxia followed by a prolonged return to normoxia acts as an effective trigger for EPO production. The mechanism depends on free O2 radicals and on reduced gluthatione ...

    • Physiological and Clinical Impact of Repeated Inhaled Oxygen Variation on Erythropoietin Levels in Patients After SurgeryPeer reviewedOpen access 

      15 septembre 2021, Khalifé, Maher; Ben Haziz, Mohamed; BALESTRA, Costantino; Valsamis, Joseph; Sosnowski, Maurice, HE Bruxelles Brabant
      Article scientifique
      The "Normobaric Oxygen Paradox" (NOP) is a physiologic mechanism that induces an increase of endogenous erythropoietin (EPO) production by creating a state of relative hypoxia in subjects previously exposed to hyperoxia, followed by a rapid return to normoxia. Oxygen exposure duration and inspired oxygen fraction required to observe a significant increase in EPO or hemoglobin are not clearly defined. ...