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Soumissions récentes

  • Physiological and Clinical Impact of Repeated Inhaled Oxygen Variation on Erythropoietin Levels in Patients After SurgeryPeer reviewedOpen access 

    15 septembre 2021, Khalifé, Maher; Ben Haziz, Mohamed; BALESTRA, Costantino; Valsamis, Joseph; Sosnowski, Maurice, HE Bruxelles Brabant
    Article scientifique
    The "Normobaric Oxygen Paradox" (NOP) is a physiologic mechanism that induces an increase of endogenous erythropoietin (EPO) production by creating a state of relative hypoxia in subjects previously exposed to hyperoxia, followed by a rapid return to normoxia. Oxygen exposure duration and inspired oxygen fraction required to observe a significant increase in EPO or hemoglobin are not clearly defined. ...
  • Editorial: Physiological telemonitoring and interventional telemedicine in extreme environmentsPeer reviewedOpen access 

    22 janvier 2024, BALESTRA, Costantino; Bosco, Gerardo; Cialoni, Danilo; Kot, Jacek; Pelliccia, Riccardo; Marroni, Alessandro, HE Bruxelles Brabant
    Article scientifique
    Editorial on physiological measuring in extreme environments
  • ULTRASONOGRAPHIC ASSESSMENT OF NECK MUSCULAR SIZE AND RANGE OF MOTION IN RUGBY PLAYERSPeer reviewedOpen access 

    01 février 2018, HEMELRYCK, Walter; Calistri, Josselin; Papadopoulou, Virginie; THEUNISSEN, Sigrid; Dugardeyn, Christian; BALESTRA, Costantino, HE Bruxelles Brabant
    Article scientifique
    Background: World Rugby Union laws are constantly evolving towards stringent injury-prevention, particularly for contested scrums, since front row players are most at risk of cervical spine injuries. Recently, some countries have also introduced tailored training programs and minimum performance requirements for playing in the front row. Nevertheless, these approaches lack an objective assessment ...
  • Physiology of repeated mixed gas 100-m wreck dives using a closed-circuit rebreather: a field bubble studyPeer reviewedOpen access 

    28 novembre 2021, BALESTRA, Costantino; Guerrero, François; THEUNISSEN, Sigrid; GERMONPRÉ, Peter; Lafère, Pierre, HE Bruxelles Brabant
    Article scientifique
    Purpose: Data regarding decompression stress after deep closed-circuit rebreather (CCR) dives are scarce. This study aimed to monitor technical divers during a wreck diving expedition and provide an insight in venous gas emboli (VGE) dynamics. Methods: Diving practices of ten technical divers were observed. They performed a series of three consecutive daily dives around 100 m. VGE counts were ...
  • Effects of Acute Hypobaric Hypoxia Exposure on Cardiovascular Function in Unacclimatized Healthy Subjects: A "Rapid Ascent" Hypobaric Chamber StudyPeer reviewedOpen access 

    28 avril 2022, THEUNISSEN, Sigrid; BALESTRA, Costantino; Bolognési, Sébastien; Borgers, Guy; Vissenaeken, Dirk; Obeid, Georges; Germonpré, Peter; Honoré, Patrick M.; De Bels, David, HE Bruxelles Brabant
    Article scientifique
    Background: This study aimed to observe the effects of a fast acute ascent to simulated high altitudes on cardiovascular function both in the main arteries and in peripheral circulation. Methods: We examined 17 healthy volunteers, between 18 and 50 years old, at sea level, at 3842 m of hypobaric hypoxia and after return to sea level. Cardiac output (CO) was measured with Doppler transthoracic ...
  • Oxidative Stress Response Kinetics after 60 Minutes at Different Levels (10% or 15%) of Normobaric Hypoxia ExposurePeer reviewedOpen access 

    15 juin 2023, Leveque, Clément; Mrakic-Sposta, Simona; THEUNISSEN, Sigrid; Germonpré, Peter; LAMBRECHTS, Kate; Vezzoli, Alessandra; Gussoni, Maristella; Levenez, Morgan; Lafère, Pierre; Guerrero, François; BALESTRA, Costantino, HE Bruxelles Brabant
    Article scientifique
    In this study, the metabolic responses of hypoxic breathing for 1 h to inspired fractions of 10% and 15% oxygen were investigated. To this end, 14 healthy nonsmoking subjects (6 females and 8 males, age: 32.2 ± 13.3 years old (mean ± SD), height: 169.1 ± 9.9 cm, and weight: 61.6 ± 16.2 kg) volunteered for the study. Blood samples were taken before, and at 30 min, 2 h, 8 h, 24 h, and 48 h after a 1 ...
  • Effects of Electrical Stimulation on Delayed Onset Muscle Soreness (DOMS): Evidences from Laboratory and In-Field StudiesPeer reviewedOpen access 

    12 septembre 2023, Gussoni, Maristella; Moretti, Sarah; Vezzoli, Alessandra; Genitoni, Valerio; Giardini, Guido; BALESTRA, Costantino; Bosco, Gerardo; Pratali, Lorenza; Spagnolo, Elisabetta; Montorsi, Michela; Mrakic-Sposta, Simona, HE Bruxelles Brabant
    Article scientifique
    Intense, long exercise can increase oxidative stress, leading to higher levels of inflammatory mediators and muscle damage. At the same time, fatigue has been suggested as one of the factors giving rise to delayed-onset muscle soreness (DOMS). The aim of this study was to investigate the efficacy of a specific electrical stimulation (ES) treatment (without elicited muscular contraction) on two ...
  • Oxygen VariationsPeer reviewedOpen access 

    26 septembre 2023, BALESTRA, Costantino; Virgili, Fabio; Mrakic-Sposta, Simona, HE Bruxelles Brabant
    Livre/Ouvrage ou monographie
    For many years, diving and hyperbaric medicine has strived to increase our understanding of the effects of environmental stressors on human pathophysiology. It has demonstrated the importance of oxygen and has taught us not to fear this oxidative molecule, the name of which is derived from the ancient Greek meaning the “acid generator” or Oxy-Gene; indeed, at that time, it was believed that all acids ...
  • Hyperbaric medicinePeer reviewedOpen access 

    12 février 2023, BALESTRA, Costantino; Kot, Jacek, HE Bruxelles Brabant
    Livre/Ouvrage ou monographie
    Oxygen (both its presence and absence) acts as a potent signaling mechanism in many, if not most, cellular processes. Oxygen has been used therapeutically mainly to alleviate or correct hypoxia, and has been administered in supra-atmospheric doses in the form of hyperbaric oxygen (a method derived from diving medicine practices, but has been used in non-diving applications since the 1960s). Hyperbaric ...
  • Oxidative Stress Response Kinetics after 60 Minutes at Different (1.4 ATA and 2.5 ATA) Hyperbaric Hyperoxia ExposuresPeer reviewedOpen access 

    02 août 2023, Leveque, Clément; Mrakic-Sposta, Simona; THEUNISSEN, Sigrid; Germonpré, Peter; LAMBRECHTS, Kate; Vezzoli, Alessandra; Bosco, Gerardo; Levenez, Morgan; Lafère, Pierre; Guerrero, François; BALESTRA, Costantino, HE Bruxelles Brabant
    Article scientifique
    Hyperbaric oxygen therapy (HBOT) is a therapeutical approach based on exposure to pure oxygen in an augmented atmospheric pressure. Although it has been used for years, the exact kinetics of the reactive oxygen species (ROS) between different pressures of hyperbaric oxygen exposure are still not clearly evidenced. In this study, the metabolic responses of hyperbaric hyperoxia exposures for 1 h at ...
  • Varying Oxygen Partial Pressure Elicits Blood-Borne Microparticles Expressing Different Cell-Specific Proteins-Toward a Targeted Use of Oxygen?Peer reviewedOpen access 

    17 juillet 2022, BALESTRA, Costantino; Arya, Awadhesh; Leveque, Clément; Virgili, Fabio; GERMONPRÉ, Peter; LAMBRECHTS, Kate; Lafere, Pierre; Thom, Stephen, HE Bruxelles Brabant
    Article scientifique
    Oxygen is a powerful trigger for cellular reactions, but there are few comparative investigations assessing the effects over a large range of partial pressures. We investigated a metabolic response to single exposures to either normobaric (10%, 15%, 30%, 100%) or hyperbaric (1.4 ATA, 2.5 ATA) oxygen. Forty-eight healthy subjects (32 males/16 females; age: 43.7 +/- 13.4 years, height: 172.7 +/- 10.07 ...
  • Effect of SCUBA Diving on Ophthalmic ParametersPeer reviewedOpen access 

    09 mars 2022, Deleu, Laurent; Catherine, Janet; Postelmans, Laurence; BALESTRA, Costantino, HE Bruxelles Brabant
    Article scientifique
    Background and Objective: Several cases of central serous chorioretinopathy (CSC) in divers have been reported in our medical retina center over the past few years. This study was designed to evaluate possible changes induced by SCUBA diving in ophthalmic parameters and especially subfoveal choroidal thickness (SFCT), since the choroid seems to play a crucial role in physiopathology of CSC. Materials ...
  • Vascular Function Recovery Following Saturation DivingPeer reviewedOpen access 

    17 octobre 2022, Imbert, Jean-Pierre; Egi, Sahli-Murat; BALESTRA, Costantino, HE Bruxelles Brabant
    Article scientifique
    Background and Objectives: Saturation diving is a technique used in commercial diving. Decompression sickness (DCS) was the main concern of saturation safety, but procedures have evolved over the last 50 years and DCS has become a rare event. New needs have evolved to evaluate the diving and decompression stress to improve the flexibility of the operations (minimum interval between dives, optimal ...
  • Full-Face Mask Use during SCUBA Diving Counters Related Oxidative Stress and Endothelial DysfunctionPeer reviewedOpen access 

    15 janvier 2022, Levenez, Morgan; LAMBRECHTS, Kate; Mrakic-Sposta, Simona; Vezzoli, Alessandra; Germonpré, Peter; Pique, Hadrien; Virgili, Fabi; Bosco, Gerardo; Lafere, Pierre; BALESTRA, Costantino, HE Bruxelles Brabant
    Article scientifique
    Impaired flow mediated dilation (FMD), an index of vascular stress, is known after SCUBA diving. This is related to a dysfunction of nitric oxide (NO) availability and a disturbance of the redox status, possibly induced by hyperoxic/hyperbaric gas breathing. SCUBA diving is usually performed with a mask only covering "half face" (HF) and therefore forcing oral breathing. Nasal NO production is ...
  • The Normobaric Oxygen Paradox-Hyperoxic Hypoxic Paradox: A Novel Expedient Strategy in Hematopoiesis Clinical IssuesPeer reviewedOpen access 

    janvier 2023, Salvagno, Michele; Coppalini, Giacomo; Taccone, Fabio-Silvio; Strapazzon, Giacomo; Mrakic-Sposta, Simona; Rocco, Monica; Khalife, Maher; BALESTRA, Costantino, HE Bruxelles Brabant
    Article scientifique
    Hypoxia, even at non-lethal levels, is one of the most stressful events for all aerobic organisms as it significantly affects a wide spectrum of physiological functions and energy production. Aerobic organisms activate countless molecular responses directed to respond at cellular, tissue, organ, and whole-body levels to cope with oxygen shortage allowing survival, including enhanced neo-angiogenesis ...
  • Hydration status during commercial saturation diving measured by bioimpedance and urine specific gravityPeer reviewedOpen access 

    29 septembre 2022, Werke, Stian Lande; Landswerk, Halvor Dagsson; Lautridou, Jacky; Imbert, Jean-Pierre; BALESTRA, Costantino; Eftedal, Ingrid, HE Bruxelles Brabant
    Article scientifique
    Excessive fluid loss triggered by hyperbaric pressure, water immersion and hot water suits causes saturation divers to be at risk of dehydration. Dehydration is associated with reductions in mental and physical performance, resulting in less effective work and an increased risk of work-related accidents. In this study we examined the hydration status of 11 male divers over 19 days of a commercial ...
  • Mini Trampoline, a New and Promising Way of SCUBA Diving Preconditioning to Reduce Vascular Gas Emboli?Peer reviewedOpen access 

    29 avril 2022, LAMBRECHTS, Kate; GERMONPRÉ, Peter; Vandenheede, Joaquim; Delorme, Manon; Lafere, Pierre; BALESTRA, Costantino, HE Bruxelles Brabant
    Article scientifique
    Background: Despite evolution in decompression algorithms, decompression illness is still an issue nowadays. Reducing vascular gas emboli (VGE) production or preserving endothelial function by other means such as diving preconditioning is of great interest. Several methods have been tried, either mechanical, cardiovascular, desaturation aimed or biochemical, with encouraging results. In this study, ...
  • Elevations of Extracellular Vesicles and Inflammatory Biomarkers in Closed Circuit SCUBA DiversPeer reviewedOpen access 

    22 mars 2023, Arya, Awadhesh; BALESTRA, Costantino; Bhopale, Veena; Tominen, Laura; Raisanen-Sokolowski, Anne; Dugrenot, Emmanuel; Thom, Stephen, HE Bruxelles Brabant
    Article scientifique
    Blood-borne extracellular vesicles and inflammatory mediators were evaluated in divers using a closed circuit rebreathing apparatus and custom-mixed gases to diminish some diving risks. "Deep" divers (n = 8) dove once to mean (+/-SD) 102.5 +/- 1.2 m of sea water (msw) for 167.3 +/- 11.5 min. "Shallow" divers (n = 6) dove 3 times on day 1, and then repetitively over 7 days to 16.4 +/- 3.7 msw, for ...
  • Editorial: Feelings of energy and fatigue: Two different moodsPeer reviewedOpen access 

    19 avril 2023, Boolani, Ali; Martin, Joel; D'acquisto, Fulvio; BALESTRA, Costantino, HE Bruxelles Brabant
    Article scientifique
    Editorial on a special topic : Fatigue
  • Pulmonary Effects of One Week of Repeated Recreational Closed-Circuit Rebreather Dives in Cold WaterPeer reviewedOpen access 

    28 décembre 2022, Gouin, Emmanuel; BALESTRA, Costantino; Orsat, Jeremy; Dugrenot, Emmanuel; L'Her, Erwan, HE Bruxelles Brabant
    Article scientifique
    Background and Objectives: The use of closed-circuit rebreathers (CCRs) in recreational diving is gaining interest. However, data regarding its physiological effects are still scarce. Immersion, cold water, hyperoxia, exercise or the equipment itself could challenge the cardiopulmonary system. The purpose of this study was to examine the impact of CCR diving on lung function and autonomous cardiac ...

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