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  • Pulpal and periodontal temperature rise during KTP laser use as a root planing complement in vitroPeer reviewedOpen access 

    2005, Nammour, S.; Rocca, J.-P.; Keiani, K.; Balestra, C.; Snoeck, T.; Powell, L.; Van Reck, J., HE Bruxelles Brabant
    Article scientifique
    OBJECTIVE: The purpose of this study was to define the optimal irradiation conditions of a KTP laser during root planing treatment. METHODS: The surfaces of 60 single-root human teeth were scaled with conventional instruments before lasing. The pulpal temperature increase was measured by means of one thermocouple placed in the pulp chamber and a second one placed on the root surface at 1 mm from the ...
  • Normobaric oxygen can enhance protein captation by the lymphatic system in healthy humans.Peer reviewedOpen access 

    janvier 2004, Balestra C; Germonpré P; Snoeck T; Ezquer M; Leduc O; Leduc A; Willeput F; Marroni A; Cali Corleo R; Vann R, HE Bruxelles Brabant
    Article scientifique
    has been advocated for a long time. Several beneficial effects of NBO have been demonstrated, one of which is the faster elimination of tissue nitrogen bubbles. During DCS occurrence, a cascade of intravascular reactions has been demonstrated. These inflammatory reactions occur within minutes of the onset of DCS, and involve the precipitation of proteins on the gas-bubble interface, causing a ...
  • The fractal approach as a tool to understand asymptomatic brain hyperintense MRI signalsPeer reviewedOpen access 

    2004, Balestra, C.; Marroni, A.; Farkas, B.; Peetrons, P.; Vanderschueren, F.; Duboc, E.; Snoeck, T.; Germonpré, P., HE Bruxelles Brabant
    Article scientifique
    The prevalence of a Patent Foramen Ovale is described in merely 30% of the asymptomatic population. This patency has been shown to be an increasing risk factor for paradoxical cerebral embolization. Some desaturation or decompression situations in human activities such as scuba diving or altitude flight are prone to provoke embolisations. The association with the presence of a patent Foramen Ovale ...
  • Evidence for increasing patency of the foramen ovale in diversPeer reviewedOpen access 

    2005, Germonpre, P.; Hastir, F.; Dendale, P.; Marroni, A.; Nguyen, A.-F.; Balestra, C., HE Bruxelles Brabant
    Article scientifique
    sing a standardized contrast-enhanced transesophageal echocardiographic technique, a group of divers was reexamined for the presence and size of patent foramen ovale (PFO) 7 years after their initial examinations. Unexpected but significant increases in the prevalence and size of PFO were found, suggesting a possible increasing risk for decompression sickness in these divers over time.
  • A deep stop during decompression from 82 fsw (25 m) significantly reduces bubbles and fast tissue gas tensions.Peer reviewedOpen access 

    janvier 2004, Marroni A; Bennett PB; Cronje FJ; Cali-Corleo R; Germonpre P; Pieri M; Bonuccelli C; Balestra C, HE Bruxelles Brabant
    Article scientifique
    n spite of many modifications to decompression algorithms, the incidence of decompression sickness (DCS) in scuba divers has changed very little. The success of stage, compared to linear ascents, is well described yet theoretical changes in decompression ratios have diminished the importance of fast tissue gas tensions as critical for bubble generation. The most serious signs and symptoms of DCS ...
  • Erythropoietin production can be enhanced by normobaric oxygen breathing in healthy humansPeer reviewedOpen access 

    2004, Balestra, C.; Germonpré, P.; Poortmans, J.; Marroni, A.; Schiettecatte, J.; Collard, J.-F.; Snoeck, T., HE Bruxelles Brabant
    Article scientifique
    Erythropoietin (EPO) induces red blood cell production by activating red bone marrow progenitor cells, and is used therapeutically in chronic anemia. It is also used as an unauthorized adjunct to increase the oxygen transport capacity in the blood of athletes. Renal tissue hypoxia is the only widely accepted trigger for EPO production (1-3), even if new oxygen-sensitive sites have been recently ...
  • Scuba diving can induce stress of the temporomandibular joint leading to headache [1]Peer reviewedOpen access 

    2004, Balestra, C.; Germonpré, P.; Marroni, A.; Snoek, T., HE Bruxelles Brabant
    Article scientifique
    In ordinary recreational scuba diving, many anatomical parts can be involved in disorders of cranial regions: ears and eyes are involved but also sinuses. Dental problems are generally involved in barotraumas because of bad dental fillings or other matters of interest to the general dental practitioner.1 Very few papers have looked at the articular and periarticular problems of the temporomandibular joint ...
  • Patent foramen ovale and decompression sickness in sports divers.Peer reviewedOpen access 

    mai 1998, Germonpré P; Dendale P; Unger P; Balestra C, HE Bruxelles Brabant
    Article scientifique
    Patency of the foramen ovale (PFO) may be a cause of unexplained decompression sickness (DCS) in sports divers. To assess the relationship between PFO and DCS, a case-control study was undertaken in a population of Belgian sports divers. Thirty-seven divers who suffered from neurological DCS were compared with matched control divers who never had DCS. All divers were investigated with transesophageal ...
  • Effects of fatigue on the stretch reflex in a human musclePeer reviewedOpen access 

    1992, Balestra, C.; Duchateau, J.; Hainaut, K., Autre
    Article scientifique
    The effects of fatigue on the electromyographic (EMG) reflex activities were compared during sustained voluntary contractions and contractions evoked by electrical stimulation (30 Hz) in the human first dorsal interosseus (FDI). Short latency (SL), medium latency (ML) and long latency (LL) reflex responses to a ramp-and-hold stretch of the muscle were recorded and analysed in 27 healthy subjects of ...
  • Reflex regulation during sustained and intermittent submaximal contractions in humansPeer reviewedOpen access 

    2002, Duchateau, J.; Balestra, C.; Carpentier, A.; Hainaut, K., HE Bruxelles Brabant
    Article scientifique
    To investigate whether the intensity and duration of a sustained contraction influences reflex regulation, we compared sustained fatiguing contractions at 25 % and 50 % of maximal voluntary contraction (MVC) force in the human abductor pollicis brevis (APB) muscle. Because the activation of motoneurones during fatigue may be reflexively controlled by the metabolic status of the muscle, we also ...
  • Intrathoracic pressure changes after Valsalva strain and other maneuvers: Implications for divers with patent foramen ovalePeer reviewedOpen access 

    1998, Balestra, C.; Germonpré, P.; Marroni, A., HE Bruxelles Brabant
    Article scientifique
    Scuba divers with patent foramen ovale (PFO) may be at risk for paradoxical nitrogen gas emboli when performing maneuvers that cause a rebound blood loading to the right atrium. We measured the rise and fall in intrathoracic pressure (ITP) during various maneuvers in 15 divers. The tests were standard isometric exercises (control), forceful coughing, knee bend (with and without respiration blocked), ...
  • The Impact of Inotropes and Vasopressors on Cerebral Oxygenation in Patients with Traumatic Brain Injury and Subarachnoid Hemorrhage: A Narrative ReviewPeer reviewedOpen access 

    24 janvier 2024, Michele Salvagno; Federico Geraldini; Giacomo Coppalini; Chiara Robba; Elisa Gouvea Bogossian; Filippo Annoni; Eva Vitali; Elda Diletta Sterchele; Costantino Balestra; Fabio Silvio Taccone, HE Bruxelles Brabant
    Article scientifique
    Traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH) are critical neurological conditions that necessitate specialized care in the Intensive Care Unit (ICU). Managing cerebral perfusion pressure (CPP) and mean arterial pressure (MAP) is of primary importance in these patients. To maintain targeted MAP and CPP, vasopressors and/or inotropes are commonly used. However, their effects on ...
  • Pulsed Hyperoxia Acts on Plasmatic Advanced Glycation End Products and Advanced Oxidation Protein Products and Modulates Mitochondrial Biogenesis in Human Peripheral Blood Mononuclear Cells: A Pilot Study on the “Normobaric Oxygen Paradox”Peer reviewedOpen access 

    18 février 2024, Costantino Balestra; Sara Baldelli; Fabio Virgili; Michele Salvagno; Simona Mrakic-Sposta; Deborah Fratantonio, HE Bruxelles Brabant
    Article scientifique
    The “normobaric oxygen paradox” (NOP) describes the response to the return to normoxia after a hyperoxic event, sensed by tissues as an oxygen shortage, up-regulating redox-sensitive tran- scription factors. We have previously characterized the time trend of oxygen-sensitive transcription factors in human PBMCs, in which the return to normoxia after 30% oxygen is sensed as a hypoxic trigger, ...
  • Oxidative Stress and Cerebral Vascular Tone: The Role of Reactive Oxygen and Nitrogen SpeciesPeer reviewedOpen access 

    05 mars 2024, Michele Salvagno; Elda Diletta Sterchele; Mario Zaccarelli; Simona Mrakic-Sposta; Ian James Welsby; Costantino Balestra; Fabio Silvio Taccone, HE Bruxelles Brabant
    Article scientifique
    he brain's unique characteristics make it exceptionally susceptible to oxidative stress, which arises from an imbalance between reactive oxygen species (ROS) production, reactive nitrogen species (RNS) production, and antioxidant defense mechanisms. This review explores the factors contributing to the brain's vascular tone's vulnerability in the presence of oxidative damage, which can be of clinical ...
  • Oxy-Inflammation in Humans during Underwater ActivitiesPeer reviewedOpen access 

    06 mars 2024, Alessandra Vezzoli; Simona Mrakic-Sposta; Andrea Brizzolari; Costantino Balestra; Enrico Maria Camporesi; Gerardo Bosco, HE Bruxelles Brabant
    Article scientifique
    Underwater activities are characterized by an imbalance between reactive oxygen/nitrogen species (RONS) and antioxidant mechanisms, which can be associated with an inflammatory response, depending on O(2) availability. This review explores the oxidative stress mechanisms and related inflammation status (Oxy-Inflammation) in underwater activities such as breath-hold (BH) diving, Self-Contained ...
  • Physiology of deep closed circuit rebreather mixed gas diving: vascular gas emboli and biological changes during a week-long liveaboard safariPeer reviewedOpen access 

    01 mars 2024, Balestra Costantino; Leveque Clément; Mrakic-Sposta Simona; Wauthy Pierre; Germonpré Peter; Tillmans Frauke; Guerrero François; Lafere Pierre; Vezzoli Alessandra, HE Bruxelles Brabant
    Article scientifique
    Introduction: Diving decompression theory hypothesizes inflammatory processes as a source of micronuclei which could increase related risks. Therefore, we tested 10 healthy, male divers. They performed 6–8 dives with a maximum of two dives per day at depths ranging from 21 to 122 msw with CCR mixed gas diving. Methods: Post-dive VGE were counted by echocardiography. Saliva and urine samples ...
  • Physiological and Clinical Impact of Repeated Inhaled Oxygen Variation on Erythropoietin Levels in Patients After SurgeryPeer reviewedOpen access 

    15 septembre 2021, Khalifé, Maher; Ben Haziz, Mohamed; BALESTRA, Costantinoorcid-id; Valsamis, Joseph; Sosnowski, Maurice, HE Bruxelles Brabant
    Article scientifique
    The "Normobaric Oxygen Paradox" (NOP) is a physiologic mechanism that induces an increase of endogenous erythropoietin (EPO) production by creating a state of relative hypoxia in subjects previously exposed to hyperoxia, followed by a rapid return to normoxia. Oxygen exposure duration and inspired oxygen fraction required to observe a significant increase in EPO or hemoglobin are not clearly defined. ...
  • Editorial: Physiological telemonitoring and interventional telemedicine in extreme environmentsPeer reviewedOpen access 

    22 janvier 2024, BALESTRA, Costantinoorcid-id; Bosco, Gerardo; Cialoni, Danilo; Kot, Jacek; Pelliccia, Riccardo; Marroni, Alessandro, HE Bruxelles Brabant
    Article scientifique
    Editorial on physiological measuring in extreme environments
  • ULTRASONOGRAPHIC ASSESSMENT OF NECK MUSCULAR SIZE AND RANGE OF MOTION IN RUGBY PLAYERSPeer reviewedOpen access 

    01 février 2018, HEMELRYCK, Walter; Calistri, Josselin; Papadopoulou, Virginie; THEUNISSEN, Sigrid; Dugardeyn, Christian; BALESTRA, Costantinoorcid-id, HE Bruxelles Brabant
    Article scientifique
    Background: World Rugby Union laws are constantly evolving towards stringent injury-prevention, particularly for contested scrums, since front row players are most at risk of cervical spine injuries. Recently, some countries have also introduced tailored training programs and minimum performance requirements for playing in the front row. Nevertheless, these approaches lack an objective assessment ...
  • Physiology of repeated mixed gas 100-m wreck dives using a closed-circuit rebreather: a field bubble studyPeer reviewedOpen access 

    28 novembre 2021, BALESTRA, Costantinoorcid-id; Guerrero, François; THEUNISSEN, Sigrid; GERMONPRÉ, Peter; Lafère, Pierre, HE Bruxelles Brabant
    Article scientifique
    Purpose: Data regarding decompression stress after deep closed-circuit rebreather (CCR) dives are scarce. This study aimed to monitor technical divers during a wreck diving expedition and provide an insight in venous gas emboli (VGE) dynamics. Methods: Diving practices of ten technical divers were observed. They performed a series of three consecutive daily dives around 100 m. VGE counts were ...

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