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    • Hemoglobin and Erythropoietin After Commercial Saturation DivingPeer reviewedOpen access 

      21 août 2018, Kiboub, Fatima Zohra; BALESTRA, Costantino; Loennechen, Øyvind; Eftedal, Ingrid, HE Bruxelles Brabant
      Article scientifique
      Saturation divers are exposed to elevated partial pressure of oxygen (ppO2) in their hyperbaric work environment. Experimental studies indicate that oxygen transport is altered, and we have previously reported a drop in hematocrit and extensive downregulation of genes involved in blood oxygen transport capacity after decompression from professional saturation diving. Here we investigate the initial ...

    • Hyperoxia Alters Ultrastructure and Induces Apoptosis in Leukemia Cell LinesPeer reviewedOpen access 

      12 février 2020, De Bels, David; Tillmans, Frauke; Corazza, Francis; Bizzarri, Mariano; GERMONPRÉ, Peter; Radermacher, Peter; Keziban, Gunce-Orman; BALESTRA, Costantino, HE Bruxelles Brabant
      Article scientifique
      Oxygenation conditions are crucial for growth and tumor progression. Recent data suggests a decrease in cancer cell proliferation occurring after exposure to normobaric hyperoxia. Those changes are associated with fractal dimension. The purpose of this research was to study the impact of hyperoxia on apoptosis and morphology of leukemia cell lines. Two hematopoietic lymphoid cancer cell lines (a ...

    • The "ON-OFF" Switching Response of Reactive Oxygen Species in Acute Normobaric Hypoxia: Preliminary OutcomePeer reviewedOpen access 

      16 février 2023, BALESTRA, Costantino; Mrakic-Sposta, Simona; Gussoni, Maristella; Marzorati, Mauro; Porcelli, Simone; Bosco, Gerardo; Montorsi, Michela; Lafortuna, Claudio; Vezzoli, Alessandra, HE Bruxelles Brabant
      Article scientifique
      Exposure to acute normobaric hypoxia (NH) elicits reactive oxygen species (ROS) accumulation, whose production kinetics and oxidative damage were here investigated. Nine subjects were monitored while breathing an NH mixture (0.125 F(I)O(2) in air, about 4100 m) and during recovery with room air. ROS production was assessed by Electron Paramagnetic Resonance in capillary blood. Total antioxidant ...

    • Oxygen Variations-Insights into Hypoxia, Hyperoxia and Hyperbaric Hyperoxia - Is the Dose the Clue?Peer reviewedOpen access 

      20 septembre 2023, BALESTRA, Costantino; Mrakic-Sposta, Simona; Virgili, Fabio, HE Bruxelles Brabant
      Article scientifique
      on, nitrogen and hydrogen); aerobic organisms depend on it to release energy from carbon-based molecules. The concentration of oxygen in the atmosphere is ~20.93–20.95% (209–460 ppm), but this has fluctuated markedly throughout geological history. It stabilized within a habitable range, between ~15% and 35%, which has been maintained from the Cambrian period 540 million years ago until today [1]. The ...