Parcourir HE Bruxelles-Brabant par sujet "Normobaric Oxygen Paradox"
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Effect Of Induced Relative Hypoxia On Reticulocyte Count In Oncologycal Abdominal Surgery: A Single-Centre, Controlled, Randomized Pilot Study.
04 avril 2018, HE Bruxelles BrabantArticle scientifiqueErythropoietin (EPO) stimulating agents are known as alternatives to transfusion. However, they expose patients to thrombosis and are expensive. A phenomenon, “the normobaric oxygen paradox” (NOP), has been described. A transient hyperoxia followed by a prolonged return to normoxia acts as an effective trigger for EPO production. The mechanism depends on free O2 radicals and on reduced gluthatione ... -
Hemoglobin and Erythropoietin After Commercial Saturation Diving
21 août 2018, HE Bruxelles BrabantArticle scientifiqueSaturation divers are exposed to elevated partial pressure of oxygen (ppO2) in their hyperbaric work environment. Experimental studies indicate that oxygen transport is altered, and we have previously reported a drop in hematocrit and extensive downregulation of genes involved in blood oxygen transport capacity after decompression from professional saturation diving. Here we investigate the initial ... -
Hyperoxia Alters Ultrastructure and Induces Apoptosis in Leukemia Cell Lines
12 février 2020, HE Bruxelles BrabantArticle scientifiqueOxygenation conditions are crucial for growth and tumor progression. Recent data suggests a decrease in cancer cell proliferation occurring after exposure to normobaric hyperoxia. Those changes are associated with fractal dimension. The purpose of this research was to study the impact of hyperoxia on apoptosis and morphology of leukemia cell lines. Two hematopoietic lymphoid cancer cell lines (a ... -
The "normobaric oxygen paradox": a new tool for the anesthetist?
10 janvier 2014, HE Bruxelles BrabantArticle scientifiqueHypoxia is the natural trigger for endogenous EPO production but recently the use of intermittent hyperoxia to stimulate EPO has been postulated and this phenomenon has been called the "normobaric oxygen paradox" (NOP). The "NOP" is a mechanism by which oxygen regulates the expression of the Hypoxia Inducible Factor 1 alpha (HIF-1alpha). The HIF-1alpha-depending gene regulation is responsible for ... -
Physiological and Clinical Impact of Repeated Inhaled Oxygen Variation on Erythropoietin Levels in Patients After Surgery
15 septembre 2021, HE Bruxelles BrabantArticle scientifiqueThe "Normobaric Oxygen Paradox" (NOP) is a physiologic mechanism that induces an increase of endogenous erythropoietin (EPO) production by creating a state of relative hypoxia in subjects previously exposed to hyperoxia, followed by a rapid return to normoxia. Oxygen exposure duration and inspired oxygen fraction required to observe a significant increase in EPO or hemoglobin are not clearly defined. ...