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    • Effect of simulated air dive and decompression sickness on the plasma proteome of ratsPeer reviewedClosed access 

      12 avril 2016, Lautridou, Jacky; Pichereau, Vianney; Artigaud, Sébastien; Buzzacott, Peter; Wang, Qiong; Bernay, Benoit; Driad, Sabrina; Mazur, Aleksandra; LAMBRECHTS, Kate; Theron, Michaël; Guerrero, François, HE Bruxelles Brabant
      Article scientifique
      Purpose: Decompression sickness (DCS) is a poorly understood systemic disease caused by inadequate desaturation following a reduction in ambient pressure. Although recent studies highlight the importance of circulating factors, the available data are still puzzling. In this study, we aimed to identify proteins and biological pathways involved in the development of DCS in rats. Experimental design: ...

    • Fluoxetine Protection in Decompression Sickness in Mice is Enhanced by Blocking TREK-1 Potassium Channel with the "spadin" AntidepressantPeer reviewedOpen access 

      16 février 2016, Vallée, Nicolas; LAMBRECHTS, Kate; De Maistre, Sébastien; Royal, Perrine; Mazella, Jean; Borsotto, Marc; Heurteaux, Catherine; Abraini, Jacques; RIsso, Jean-Jacques; Blatteau, Jean-Eric, HE Bruxelles Brabant
      Article scientifique
      In mice, disseminated coagulation, inflammation, and ischemia induce neurological damage that can lead to death. These symptoms result from circulating bubbles generated by a pathogenic decompression. Acute fluoxetine treatment or the presence of the TREK-1 potassium channel increases the survival rate when mice are subjected to an experimental dive/decompression protocol. This is a paradox because ...

    • Pre-dive Whole-Body Vibration Better Reduces Decompression-Induced Vascular Gas Emboli than Oxygenation or a Combination of BothPeer reviewedOpen access 

      30 novembre 2016, BALESTRA, Costantino; THEUNISSEN, Sigrid; Papadopoulou, Virginie; Le Mener, Cédric; GERMONPRÉ, Peter; Guerrero, François; Lafère, Pierre, HE Bruxelles Brabant
      Article scientifique
      Purpose: Since non-provocative dive profiles are no guarantor of protection against decompression sickness, novel means including pre-dive "preconditioning" interventions, are proposed for its prevention. This study investigated and compared the effect of pre-dive oxygenation, pre-dive whole body vibration or a combination of both on post-dive bubble formation. Methods: Six healthy volunteers performed ...