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Relationships between plasma lipids, proteins, surface tension and post-dive bubbles
13 février 2015,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Decompression sickness (DCS) in divers is caused by bubbles of inert gas. When DCS occurs, most bubbles can be found in the venous circulation: venous gas emboli (VGE). Bubbles are thought to be stabilized by low molecular weight surfactant reducing the plasma-air surface tension (γ). Proteins may play a role as well. We studied the interrelations between these substances, γ and VGE, measured before ...
The "normobaric oxygen paradox": a new tool for the anesthetist?
10 janvier 2014,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Hypoxia is the natural trigger for endogenous EPO production but recently the use of intermittent hyperoxia to stimulate EPO has been postulated and this phenomenon has been called the "normobaric oxygen paradox" (NOP). The "NOP" is a mechanism by which oxygen regulates the expression of the Hypoxia Inducible Factor 1 alpha (HIF-1alpha). The HIF-1alpha-depending gene regulation is responsible for ...
Fluoxetine stimulates anti-inflammatory IL-10 cytokine production and attenuates sensory deficits in a rat model of decompression sickness
22 octobre 2015,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Despite "gold standard" hyperbaric oxygen treatment, 30% of patients suffering from neurological decompression sickness still exhibit incomplete recovery, including sensory impairments. Fluoxetine, a well-known antidepressant, is recognized as having anti-inflammatory effects in the setting of cerebral ischemia. In this study, we focused on the assessment of sensory neurological deficits and measurement ...
Age, weight and decompression sickness in rats
16 mars 2016,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Objective: The aim of this study was to determine if, after controlling for weight, age is associated with decompression sickness (DCS) in rats. Methods: Following compression-decompression, male rats aged 11 weeks were observed for DCS. After two weeks recovery, surviving rats were re-dived using the same compression-decompression profile. Results: In this experiment, there was a clear difference ...
Colonic Fermentation Promotes Decompression sickness in Rats
08 février 2016,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Massive bubble formation after diving can lead to decompression sickness (DCS). During dives with hydrogen as a diluent for oxygen, decreasing the body's H2 burden by inoculating hydrogen-metabolizing microbes into the gut reduces the risk of DCS. So we set out to investigate if colonic fermentation leading to endogenous hydrogen production promotes DCS in fasting rats. Four hours before an experimental ...
Effect of simulated air dive and decompression sickness on the plasma proteome of rats
12 avril 2016,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Purpose: Decompression sickness (DCS) is a poorly understood systemic disease caused by inadequate desaturation following a reduction in ambient pressure. Although recent studies highlight the importance of circulating factors, the available data are still puzzling. In this study, we aimed to identify proteins and biological pathways involved in the development of DCS in rats.
Experimental design: ...
Effect of oxygen-breathing during a decompression-stop on bubble-induced platelet activation after an open-sea air dive: oxygen-stop decompression
29 septembre 2013,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Purpose: We highlighted a relationship between decompression-induced bubble formation and platelet micro-particle (PMP) release after a scuba air-dive. It is known that decompression protocol using oxygen-stop accelerates the washout of nitrogen loaded in tissues. The aim was to study the effect of oxygen deco-stop on bubble formation and cell-derived MP release.
Methods: Healthy experienced ...
Effect of decompression-induced bubble formation on highly trained divers microvascular function
07 novembre 2013,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
We previously showed microvascular alteration of both endothelium-dependent and -independent reactivity after a single SCUBA dive. We aimed to study mechanisms involved in this postdive vascular dysfunction. Ten divers each completed three protocols: (1) a SCUBA dive at 400 kPa for 30 min; (2) a 41-min duration of seawater surface head immersed finning exercise to determine the effect of immersion ...
Effect of splenectomy on platelet activation and decompression sickness outcome in a rat model of decompression
01 septembre 2014,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Introduction: Splenic platelets have been recognized to have a greater prothrombotic potential than others platelets. We studied whether platelets released by splenic contraction could influence the severity and outcome of decompression sickness (DCS) and bubble-induced platelet activation.
Methods: Sixteen, male Sprague-Dawley rats were randomly assigned to either a control or a splenectomized ...
Mechanism of action of antiplatelet drugs on decompression sickness in rats: a protective effect of anti-GPIIbIIIa therapy
15 mai 2015,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Literature highlights the involvement of disseminated thrombosis in the pathophysiology of decompression sickness (DCS). We examined the effect of several antithrombotic treatments targeting various pathways on DCS outcome: acetyl salicylate, prasugrel, abciximab, and enoxaparin. Rats were randomly assigned to six groups. Groups 1 and 2 were a control nondiving group (C; n = 10) and a control diving ...