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Editorial: Physiological telemonitoring and interventional telemedicine in extreme environments![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
22 janvier 2024, BALESTRA, Costantino
; Bosco, Gerardo; Cialoni, Danilo; Kot, Jacek; Pelliccia, Riccardo; Marroni, Alessandro,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Oxygen Variations![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
26 septembre 2023, BALESTRA, Costantino
; Virgili, Fabio; Mrakic-Sposta, Simona,
- HE Bruxelles Brabant
,
- Livre/Ouvrage ou monographie
Livre/Ouvrage ou monographie
For many years, diving and hyperbaric medicine has strived to increase our understanding of the effects of environmental stressors on human pathophysiology. It has demonstrated the importance of oxygen and has taught us not to fear this oxidative molecule, the name of which is derived from the ancient Greek meaning the “acid generator” or Oxy-Gene; indeed, at that time, it was believed that all acids ...
Oxygen Variations-Insights into Hypoxia, Hyperoxia and Hyperbaric Hyperoxia - Is the Dose the Clue?![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
20 septembre 2023, BALESTRA, Costantino
; Mrakic-Sposta, Simona; Virgili, Fabio,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
on, nitrogen and hydrogen); aerobic organisms depend on it to release energy from carbon-based molecules. The concentration of oxygen in the atmosphere is ~20.93–20.95% (209–460 ppm), but this has fluctuated markedly throughout geological history. It stabilized within a habitable range, between ~15% and 35%, which has been maintained from the Cambrian period 540 million years ago until today [1].
The ...
Effects of Electrical Stimulation on Delayed Onset Muscle Soreness (DOMS): Evidences from Laboratory and In-Field Studies![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
12 septembre 2023, Gussoni, Maristella; Moretti, Sarah; Vezzoli, Alessandra; Genitoni, Valerio; Giardini, Guido; BALESTRA, Costantino
; Bosco, Gerardo; Pratali, Lorenza; Spagnolo, Elisabetta; Montorsi, Michela; Mrakic-Sposta, Simona,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Intense, long exercise can increase oxidative stress, leading to higher levels of inflammatory
mediators and muscle damage. At the same time, fatigue has been suggested as one of the factors
giving rise to delayed-onset muscle soreness (DOMS). The aim of this study was to investigate the
efficacy of a specific electrical stimulation (ES) treatment (without elicited muscular contraction) on
two ...
Oxidative Stress Response Kinetics after 60 Minutes at Different (1.4 ATA and 2.5 ATA) Hyperbaric Hyperoxia Exposures![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
02 août 2023, Leveque, Clément; Mrakic-Sposta, Simona; THEUNISSEN, Sigrid; Germonpré, Peter; LAMBRECHTS, Kate; Vezzoli, Alessandra; Bosco, Gerardo; Levenez, Morgan; Lafère, Pierre; Guerrero, François; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Hyperbaric oxygen therapy (HBOT) is a therapeutical approach based on exposure to pure oxygen in an augmented atmospheric pressure. Although it has been used for years, the exact kinetics of the reactive oxygen species (ROS) between different pressures of hyperbaric oxygen exposure are still not clearly evidenced. In this study, the metabolic responses of hyperbaric hyperoxia exposures for 1 h at ...
Oxidative Stress Response Kinetics after 60 Minutes at Different Levels (10% or 15%) of Normobaric Hypoxia Exposure![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
15 juin 2023, Leveque, Clément; Mrakic-Sposta, Simona; THEUNISSEN, Sigrid; Germonpré, Peter; LAMBRECHTS, Kate; Vezzoli, Alessandra; Gussoni, Maristella; Levenez, Morgan; Lafère, Pierre; Guerrero, François; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
In this study, the metabolic responses of hypoxic breathing for 1 h to inspired fractions of 10% and 15% oxygen were investigated. To this end, 14 healthy nonsmoking subjects (6 females and 8 males, age: 32.2 ± 13.3 years old (mean ± SD), height: 169.1 ± 9.9 cm, and weight: 61.6 ± 16.2 kg) volunteered for the study. Blood samples were taken before, and at 30 min, 2 h, 8 h, 24 h, and 48 h after a 1 ...
Editorial: Feelings of energy and fatigue: Two different moods![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
19 avril 2023, Boolani, Ali; Martin, Joel; D'acquisto, Fulvio; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Architectural and Mechanical Changes after Five Weeks of Intermittent Static Stretch Training on the Medial Gastrocnemius Muscle of Active Adults![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
27 mars 2023, Levenez, Morgan; Moeremans, Mathieu; Boorghs, Cédric; Vigouroux, Florent; Leveque, Clément; HEMELRYCK, Walter; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
We investigated the effects of intermittent long-term stretch training (5 weeks) on the architectural and mechanical properties of the muscle-tendon unit (MTU) in healthy humans. MTU's viscoelastic and architectural properties in the human medial gastrocnemius (MG) muscle and the contribution of muscle and tendon structures to the MTU lengthening were analyzed. Ten healthy volunteers participated ...
Elevations of Extracellular Vesicles and Inflammatory Biomarkers in Closed Circuit SCUBA Divers![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
22 mars 2023, Arya, Awadhesh; BALESTRA, Costantino
; Bhopale, Veena; Tominen, Laura; Raisanen-Sokolowski, Anne; Dugrenot, Emmanuel; Thom, Stephen,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Blood-borne extracellular vesicles and inflammatory mediators were evaluated in divers using a closed circuit rebreathing apparatus and custom-mixed gases to diminish some diving risks. "Deep" divers (n = 8) dove once to mean (+/-SD) 102.5 +/- 1.2 m of sea water (msw) for 167.3 +/- 11.5 min. "Shallow" divers (n = 6) dove 3 times on day 1, and then repetitively over 7 days to 16.4 +/- 3.7 msw, for ...
The "ON-OFF" Switching Response of Reactive Oxygen Species in Acute Normobaric Hypoxia: Preliminary Outcome![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
16 février 2023, BALESTRA, Costantino
; Mrakic-Sposta, Simona; Gussoni, Maristella; Marzorati, Mauro; Porcelli, Simone; Bosco, Gerardo; Montorsi, Michela; Lafortuna, Claudio; Vezzoli, Alessandra,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Exposure to acute normobaric hypoxia (NH) elicits reactive oxygen species (ROS) accumulation, whose production kinetics and oxidative damage were here investigated. Nine subjects were monitored while breathing an NH mixture (0.125 F(I)O(2) in air, about 4100 m) and during recovery with room air. ROS production was assessed by Electron Paramagnetic Resonance in capillary blood. Total antioxidant ...
Hyperbaric medicine![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
12 février 2023, BALESTRA, Costantino
; Kot, Jacek,
- HE Bruxelles Brabant
,
- Livre/Ouvrage ou monographie
Livre/Ouvrage ou monographie
Oxygen (both its presence and absence) acts as a potent signaling mechanism in many, if not
most, cellular processes.
Oxygen has been used therapeutically mainly to alleviate or correct hypoxia, and has been
administered in supra-atmospheric doses in the form of hyperbaric oxygen (a method derived from
diving medicine practices, but has been used in non-diving applications since the 1960s).
Hyperbaric ...
The Normobaric Oxygen Paradox-Hyperoxic Hypoxic Paradox: A Novel Expedient Strategy in Hematopoiesis Clinical Issues![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
janvier 2023, Salvagno, Michele; Coppalini, Giacomo; Taccone, Fabio-Silvio; Strapazzon, Giacomo; Mrakic-Sposta, Simona; Rocco, Monica; Khalife, Maher; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Hypoxia, even at non-lethal levels, is one of the most stressful events for all aerobic organisms as it significantly affects a wide spectrum of physiological functions and energy production. Aerobic organisms activate countless molecular responses directed to respond at cellular, tissue, organ, and whole-body levels to cope with oxygen shortage allowing survival, including enhanced neo-angiogenesis ...
Oxidative Stress Response’s Kinetics after 60 Minutes at Different (30% or 100%) Normobaric Hyperoxia Exposures![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
30 décembre 2022, Leveque, Clément; Mrakic-Sposta, Simona; Lafère, Pierre; Vezzoli, Alessandra; Germonpré, Peter; Beer, Alexandre; Mievis, Stéphane; Virgili, Fabio; LAMBRECHTS, Kate; THEUNISSEN, Sigrid; Guerrero, François; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Oxygen is a powerful trigger for cellular reactions and is used in many pathologies,
including oxidative stress. However, the effects of oxygen over time and at different partial pressures
remain poorly understood. In this study, the metabolic responses of normobaric oxygen intake
for 1 h to mild (30%) and high (100%) inspired fractions were investigated. Fourteen healthy nonsmoking subjects (7 ...
Pulmonary Effects of One Week of Repeated Recreational Closed-Circuit Rebreather Dives in Cold Water![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
28 décembre 2022, Gouin, Emmanuel; BALESTRA, Costantino
; Orsat, Jeremy; Dugrenot, Emmanuel; L'Her, Erwan,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Background and Objectives: The use of closed-circuit rebreathers (CCRs) in recreational diving is gaining interest. However, data regarding its physiological effects are still scarce. Immersion, cold water, hyperoxia, exercise or the equipment itself could challenge the cardiopulmonary system. The purpose of this study was to examine the impact of CCR diving on lung function and autonomous cardiac ...
Vascular Function Recovery Following Saturation Diving![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
17 octobre 2022, Imbert, Jean-Pierre; Egi, Sahli-Murat; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Background and Objectives: Saturation diving is a technique used in commercial diving. Decompression sickness (DCS) was the main concern of saturation safety, but procedures have evolved over the last 50 years and DCS has become a rare event. New needs have evolved to evaluate the diving and decompression stress to improve the flexibility of the operations (minimum interval between dives, optimal ...
Hydration status during commercial saturation diving measured by bioimpedance and urine specific gravity![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
29 septembre 2022, Werke, Stian Lande; Landswerk, Halvor Dagsson; Lautridou, Jacky; Imbert, Jean-Pierre; BALESTRA, Costantino
; Eftedal, Ingrid,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Excessive fluid loss triggered by hyperbaric pressure, water immersion and hot water suits causes saturation divers to be at risk of dehydration. Dehydration is associated with reductions in mental and physical performance, resulting in less effective work and an increased risk of work-related accidents. In this study we examined the hydration status of 11 male divers over 19 days of a commercial ...
Varying Oxygen Partial Pressure Elicits Blood-Borne Microparticles Expressing Different Cell-Specific Proteins-Toward a Targeted Use of Oxygen?![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
17 juillet 2022, BALESTRA, Costantino
; Arya, Awadhesh; Leveque, Clément; Virgili, Fabio; GERMONPRÉ, Peter; LAMBRECHTS, Kate; Lafere, Pierre; Thom, Stephen,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Oxygen is a powerful trigger for cellular reactions, but there are few comparative investigations assessing the effects over a large range of partial pressures. We investigated a metabolic response to single exposures to either normobaric (10%, 15%, 30%, 100%) or hyperbaric (1.4 ATA, 2.5 ATA) oxygen. Forty-eight healthy subjects (32 males/16 females; age: 43.7 +/- 13.4 years, height: 172.7 +/- 10.07 ...
Mini Trampoline, a New and Promising Way of SCUBA Diving Preconditioning to Reduce Vascular Gas Emboli?![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
29 avril 2022, LAMBRECHTS, Kate; GERMONPRÉ, Peter; Vandenheede, Joaquim; Delorme, Manon; Lafere, Pierre; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Background: Despite evolution in decompression algorithms, decompression illness is still an issue nowadays. Reducing vascular gas emboli (VGE) production or preserving endothelial function by other means such as diving preconditioning is of great interest. Several methods have been tried, either mechanical, cardiovascular, desaturation aimed or biochemical, with encouraging results. In this study, ...
Effects of Acute Hypobaric Hypoxia Exposure on Cardiovascular Function in Unacclimatized Healthy Subjects: A "Rapid Ascent" Hypobaric Chamber Study![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
28 avril 2022, THEUNISSEN, Sigrid; BALESTRA, Costantino
; Bolognési, Sébastien; Borgers, Guy; Vissenaeken, Dirk; Obeid, Georges; Germonpré, Peter; Honoré, Patrick M.; De Bels, David,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Background: This study aimed to observe the effects of a fast acute ascent to simulated high altitudes on cardiovascular function both in the main arteries and in peripheral circulation. Methods: We examined 17 healthy volunteers, between 18 and 50 years old, at sea level, at 3842 m of hypobaric hypoxia and after return to sea level. Cardiac output (CO) was measured with Doppler transthoracic ...
Effect of SCUBA Diving on Ophthalmic Parameters![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
09 mars 2022, Deleu, Laurent; Catherine, Janet; Postelmans, Laurence; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Background and Objective: Several cases of central serous chorioretinopathy (CSC) in divers have been reported in our medical retina center over the past few years. This study was designed to evaluate possible changes induced by SCUBA diving in ophthalmic parameters and especially subfoveal choroidal thickness (SFCT), since the choroid seems to play a crucial role in physiopathology of CSC. Materials ...
Full-Face Mask Use during SCUBA Diving Counters Related Oxidative Stress and Endothelial Dysfunction![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
15 janvier 2022, Levenez, Morgan; LAMBRECHTS, Kate; Mrakic-Sposta, Simona; Vezzoli, Alessandra; Germonpré, Peter; Pique, Hadrien; Virgili, Fabi; Bosco, Gerardo; Lafere, Pierre; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Impaired flow mediated dilation (FMD), an index of vascular stress, is known after SCUBA diving. This is related to a dysfunction of nitric oxide (NO) availability and a disturbance of the redox status, possibly induced by hyperoxic/hyperbaric gas breathing. SCUBA diving is usually performed with a mask only covering "half face" (HF) and therefore forcing oral breathing. Nasal NO production is ...
Physiology of repeated mixed gas 100-m wreck dives using a closed-circuit rebreather: a field bubble study![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
28 novembre 2021, BALESTRA, Costantino
; Guerrero, François; THEUNISSEN, Sigrid; GERMONPRÉ, Peter; Lafère, Pierre,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Purpose: Data regarding decompression stress after deep closed-circuit rebreather (CCR) dives are scarce. This study aimed to monitor technical divers during a wreck diving expedition and provide an insight in venous gas emboli (VGE) dynamics.
Methods: Diving practices of ten technical divers were observed. They performed a series of three consecutive daily dives around 100 m. VGE counts were ...
Comparison of insulation provided by dry or wetsuits among recreational divers during cold water immersion (< 5 degrees C)![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
05 octobre 2021, Lafère, Pierre; Guerrero, François; GERMONPRÉ, Peter; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
BACKGROUND: Divers thermal status influences susceptibility to decompression sickness hence the need for proper insulation during immersion in cold water. However, there is a lack of data on thermal protection provided by diving suits, hence this study. MATERIALS AND METHODS: Two different groups of divers wearing either a wetsuit (n = 15) or a dry suit (n = 15) volunteered for this study. Anthropometric ...
Comparison of insulation provided by dry or wetsuits among recreational divers during cold water immersion (< 5 degrees C)![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
05 octobre 2021, Lafère, Pierre; Guerrero, François; GERMONPRÉ, Peter; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
BACKGROUND: Divers thermal status influences susceptibility to decompression sickness hence the need for proper insulation during immersion in cold water. However, there is a lack of data on thermal protection provided by diving suits, hence this study. MATERIALS AND METHODS: Two different groups of divers wearing either a wetsuit (n = 15) or a dry suit (n = 15) volunteered for this study. Anthropometric ...
Physiological and Clinical Impact of Repeated Inhaled Oxygen Variation on Erythropoietin Levels in Patients After Surgery![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
15 septembre 2021, Khalifé, Maher; Ben Haziz, Mohamed; BALESTRA, Costantino
; Valsamis, Joseph; Sosnowski, Maurice,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
The "Normobaric Oxygen Paradox" (NOP) is a physiologic mechanism that induces an increase of endogenous erythropoietin (EPO) production by creating a state of relative hypoxia in subjects previously exposed to hyperoxia, followed by a rapid return to normoxia. Oxygen exposure duration and inspired oxygen fraction required to observe a significant increase in EPO or hemoglobin are not clearly defined. ...
Heart Rate Variability During a Standard Dive: A Role for Inspired Oxygen Pressure?![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
13 août 2021, Lafère, Pierre; LAMBRECHTS, Kate; GERMONPRÉ, Peter; Balestra, Ambre; Germonpré, Faye-Lisa; Marroni, Alessandro; Cialoni, Danilo; Bosco, Gerardo; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Introduction: Heart rate variability (HRV) during underwater diving has been infrequently investigated because of environment limitations and technical challenges. This study aims to analyze HRV changes while diving at variable hyperoxia when using open circuit (OC) air diving apparatus or at constant hyperoxia using a closed-circuit rebreather (CCR). We used HRV analysis in time and frequency domain ...
Heart Rate Variability During a Standard Dive: A Role for Inspired Oxygen Pressure?![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
13 août 2021, Lafère, Pierre; LAMBRECHTS, Kate; GERMONPRÉ, Peter; BALESTRA, Ambre; Germonpré, Faye-Lisa; Marroni, Alessandro; Cialoni, Danilo; Bosco, Gerardo; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Introduction: Heart rate variability (HRV) during underwater diving has been infrequently investigated because of environment limitations and technical challenges. This study aims to analyze HRV changes while diving at variable hyperoxia when using open circuit (OC) air diving apparatus or at constant hyperoxia using a closed-circuit rebreather (CCR). We used HRV analysis in time and frequency domain ...
A fully automated method for late ventricular diastole frame selection in post-dive echocardiography without ECG gatingEr![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
02 mars 2021, Markley, Eric; Germonpré, Peter; BALESTRA, Costantino
; Tillmans, Frauke; Denoble, Petar; Freiberger, Jake; Moon, Richard; Dayton, Paul; Papadopoulou, Virginie,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Venous gas emboli (VGE) are often quantified as a marker of decompression stress on echocardiograms. Bubble-counting has been proposed as an easy to learn method, but remains time-consuming, rendering large dataset analysis impractical. Computer automation of VGE counting following this method has therefore been suggested as a means to eliminate rater bias and save time. A necessary step for this ...
A fully automated method for late ventricular diastole frame selection in post-dive echocardiography without ECG gating![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
02 mars 2021, Markley, Eric; Le, David; Germonpré, Peter; BALESTRA, Costantino
; Tillmans, Frauke; Denoble, Petar; Freiberger, Jake; Moon, Richard; Dayton, Paul; Papadopoulou, Virginie,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Venous gas emboli (VGE) are often quantified as a marker of decompression stress on echocardiograms. Bubble-counting has been proposed as an easy to learn method, but remains time-consuming, rendering large dataset analysis impractical. Computer automation of VGE counting following this method has therefore been suggested as a means to eliminate rater bias and save time. A necessary step for this ...
Feasibility of Detecting Brain Areas Involved in Extreme Breath-Hold Diving![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
20 janvier 2021, Jissendi-Tchofo, Patrice; Jdaoudi, Yassin; GERMONPRÉ, Peter; Brizzolari, Andrea; Musimu, Patrick; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
We report Blood Oxygen Level Dependent (BOLD) signal changes recorded in the brain of an elite breath-hold diver during voluntary dry long breath-hold by means of fMRI. An independent component analysis (ICA) method was applied to extract brain areas that are putatively involved in the apnea process network. We discuss the hypothesis that these BOLD signal variations express the functional adaptive ...
Increasing Oxygen Partial Pressures Induce a Distinct Transcriptional Response in Human PBMC: A Pilot Study on the “Normobaric Oxygen Paradox”![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
05 janvier 2021, Fratantonio, Deborah; Virgili, Fabio; Zucchi, Alessandro; LAMBRECHTS, Kate; Latronico, Tiziana; Lafère, Pierre; Germonpré, Pierre; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
The term "normobaric oxygen paradox" (NOP), describes the response to the return to normoxia after a hyperoxic event, sensed by tissues as oxygen shortage, and resulting in up-regulation of the Hypoxia-inducible factor 1alpha (HIF-1alpha) transcription factor activity. The molecular characteristics of this response have not been yet fully characterized. Herein, we report the activation time trend ...
Investigating critical flicker fusion frequency for monitoring gas narcosis in divers![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
17 décembre 2020, Vrijdag, Xavier; Van Waart, Hanna; Sleigh, Jaimie; BALESTRA, Costantino
; Mitchell, Simon,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
INTRODUCTION: Critical flicker fusion frequency (CFFF) has been used in various studies to measure the cognitive effects of gas mixtures at depth, sometimes with conflicting or apparently paradoxical results. This study aimed to evaluate a novel automatic CFFF method and investigate whether CFFF can be used to monitor gas-induced narcosis in divers. METHODS: Three hyperbaric chamber experiments were ...
Physiological characteristics associated with increased resistance to decompression sickness in male and female rats![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
23 juillet 2020, Lautridou, Jacky; Dugrenot, Emmanuel; Amérand, Aline; Guernec, Anthony; Pichavant-Rafini, Karine; Gouvanec, Christelle; Inizan, Manon; Albacete, Gaelle; Belhomme, Marc; Galinat, Hubert; Lafère, Pierre; BALESTRA, Costantino
; Guerrero, François; Moisan, Chistine; Buzzacott, Peter,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Decompression sickness (DCS) is a complex and poorly understood systemic disease with wide inter-individual resistance variability. We selectively bred rats with a 3-fold greater resistance to DCS than standard ones. To investigate possible physiological mechanisms underlying the resistance to DCS, including sex-related differences in these mechanisms, 15 males and 15 females resistant to DCS were ...
Evaluation of Protection Level, Respiratory Safety, and Practical Aspects of Commercially Available Snorkel Masks as Personal Protection Devices Against Aerosolized Contaminants and SARS-CoV2![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
15 juin 2020, GERMONPRÉ, Peter; Van Rompaeye, Dirk; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Introduction: The “Severe Acute Respiratory Syndrome Coronavirus 2” (SARS-CoV2) pandemic has led to a worldwide shortage of personal protection devices (PPD) for medical and paramedical personnel. Adaptation of commercially available snorkel masks to serve as full face masks has been proposed. Even not formally approved as PPD, they are publicized on social media as suitable for this use. Concerns ...
Field study of anthropomorphic and muscle performance changes among elite skippers following a transoceanic race![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
12 juin 2020, Lafère, Pierre; Gatzoff, Yann; Guerrero, François; Provyn, Steven; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
BACKGROUND: Ocean racing has become increasingly demanding, both physically and psychologically. The aim of the study was to assess global changes after a transoceanic race. MATERIALS AND METHODS: Eight male sailors were evaluated pre- and post-race through anthropometric measurements (weight, skinfold, girth at different level and estimated body fat percentage), multifrequency tetrapolar bioelectrical ...
Early Endothelial Dysfunction in Type 1 Diabetes Is Accompanied by an Impairment of Vascular Smooth Muscle Function: A Meta-Analysis![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
05 mai 2020, Lespagnol, Elodie; Dauchet, Luc; Pawlak-Chaouch, Mehdi; BALESTRA, Costantino
; Berthoin, Serge; Feelish, Martin; Roustit, Mathieu; Boissiere, Julien; Fontaine, Pierre; Heyman, Elsa,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Background: A large yet heterogeneous body of literature exists suggesting that endothelial dysfunction appears early in type 1 diabetes, due to hyperglycemia-induced oxidative stress. The latter may also affect vascular smooth muscles (VSM) function, a layer albeit less frequently considered in that pathology. This meta-analysis aims at evaluating the extent, and the contributing risk factors, of ...
Hyperoxia Alters Ultrastructure and Induces Apoptosis in Leukemia Cell Lines![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
12 février 2020, De Bels, David; Tillmans, Frauke; Corazza, Francis; Bizzarri, Mariano; GERMONPRÉ, Peter; Radermacher, Peter; Keziban, Gunce-Orman; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Oxygenation conditions are crucial for growth and tumor progression. Recent data suggests a decrease in cancer cell proliferation occurring after exposure to normobaric hyperoxia. Those changes are associated with fractal dimension. The purpose of this research was to study the impact of hyperoxia on apoptosis and morphology of leukemia cell lines. Two hematopoietic lymphoid cancer cell lines (a ...
Static Metabolic Bubbles as Precursors of Vascular Gas Emboli During Divers' Decompression: A Hypothesis Explaining Bubbling Variability![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
30 juillet 2019, Imbert, Jean Pierre; Egi, Salih Murat; GERMONPRÉ, Peter; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Introduction: The risk for decompression sickness (DCS) after hyperbaric exposures (such as SCUBA diving) has been linked to the presence and quantity of vascular gas emboli (VGE) after surfacing from the dive. These VGE can be semi-quantified by ultrasound Doppler and quantified via precordial echocardiography. However, for an identical dive, VGE monitoring of divers shows variations related to ...
Early detection of diving-related cognitive impairment of different nitrogen-oxygen gas mixtures![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
30 juin 2019, Lafère, Pierre; HEMELRYCK, Walter; GERMONPRÉ, Peter; Matity, Luba; Guerrero, François; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
NTRODUCTION: Cognitive impairment related to inert gas narcosis (IGN) is a threat to diving safety and operations at depth that might be reduced by using enriched air nitrox (EANx) mixtures. Using critical flicker fusion frequency (CFFF), a possible early detection of cognitive abilities/cerebral arousal impairment when breathing different oxygen (O2) fractions was investigated. METHODS: Eight male ...
Diving physiopathology: the end of certainties? Food for thought![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
27 juin 2019, BALESTRA, Costantino
; GERMONPRÉ, Peter; Rocco, Monica; Biancofiore, Giovanni; Kot, Jacek,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Our understanding of decompression physiopathology has slowly improved during this last decade and some uncertainties have disappeared. A better understanding of anatomy and functional aspects of Patent Foramen Ovale (PFO) have slowly resulted in a more liberal approach toward the medical fitness to dive for those bearing a PFO. Circulating vascular gas emboli (VGE) are considered the key actors in ...