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Venous gas emboli are involved in post-dive macro, but not microvascular dysfunction![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
21 janvier 2017, LAMBRECHTS, Kate; BALESTRA, Costantino
; Theron, Michaël; Henckes, Anne; Galinat, Hubert; Mignant, Fanny; Belhomme, Marc; Pontier, Jean-Michel; Guerrero, François,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Purpose: Previous studies have shown vascular dysfunction of main conductance arteries and microvessels after diving. We aim to evaluate the impact of bubble formation on vascular function and haemostasis. To achieve this, we used a vibration preconditioning to influence bubble levels without changing any other parameters linked to the dive.
Methods: Twentty-six divers were randomly assigned to ...
Vascular Function Recovery Following Saturation Diving![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
17 octobre 2022, Imbert, Jean-Pierre; Egi, Sahli-Murat; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Background and Objectives: Saturation diving is a technique used in commercial diving. Decompression sickness (DCS) was the main concern of saturation safety, but procedures have evolved over the last 50 years and DCS has become a rare event. New needs have evolved to evaluate the diving and decompression stress to improve the flexibility of the operations (minimum interval between dives, optimal ...
Varying Oxygen Partial Pressure Elicits Blood-Borne Microparticles Expressing Different Cell-Specific Proteins-Toward a Targeted Use of Oxygen?![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
17 juillet 2022, BALESTRA, Costantino
; Arya, Awadhesh; Leveque, Clément; Virgili, Fabio; GERMONPRÉ, Peter; LAMBRECHTS, Kate; Lafere, Pierre; Thom, Stephen,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Oxygen is a powerful trigger for cellular reactions, but there are few comparative investigations assessing the effects over a large range of partial pressures. We investigated a metabolic response to single exposures to either normobaric (10%, 15%, 30%, 100%) or hyperbaric (1.4 ATA, 2.5 ATA) oxygen. Forty-eight healthy subjects (32 males/16 females; age: 43.7 +/- 13.4 years, height: 172.7 +/- 10.07 ...
Variability in circulating gas emboli after a same scuba diving exposure![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
30 avril 2018, Papadopoulou, Virginie; Germonpré, Peter; Cosgrove, David; Eckersley, Robert; Dayton, Paul; Obeid, Georges; BOUTROS, Antoine; Tang, Meng-Txing; THEUNISSEN, Sigrid; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
PURPOSE: A reduction in ambient pressure or decompression from scuba diving can result in ultrasound-detectable venous gas emboli (VGE). These environmental exposures carry a risk of decompression sickness (DCS) which is mitigated by adherence to decompression schedules; however, bubbles are routinely observed for dives well within these limits and significant inter-personal variability in DCS risk ...
Ultrasound lung "comets" increase after breath-hold diving![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
23 octobre 2010, LAMBRECHTS, Kate; GERMONPRÉ, Peter; Charbel, Brian; Cialoni, Danilo; Musimu, Patrick; Sponsiello, Nicola; Marroni, Alessandro; Pastouret, Fredéric; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
The purpose of the study was to analyze the ultrasound lung comets (ULCs) variation, which are a sign of extra-vascular lung water. Forty-two healthy individuals performed breath-hold diving in different conditions: dynamic surface apnea; deep variable-weight apnea and shallow, face immersed without effort (static maximal and non-maximal). The number of ULCs was evaluated by means of an ultrasound ...
ULTRASONOGRAPHIC ASSESSMENT OF NECK MUSCULAR SIZE AND RANGE OF MOTION IN RUGBY PLAYERS![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
01 février 2018, HEMELRYCK, Walter; Calistri, Josselin; Papadopoulou, Virginie; THEUNISSEN, Sigrid; Dugardeyn, Christian; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Background: World Rugby Union laws are constantly evolving towards stringent injury-prevention, particularly for contested scrums, since front row players are most at risk of cervical spine injuries. Recently, some countries have also introduced tailored training programs and minimum performance requirements for playing in the front row. Nevertheless, these approaches lack an objective assessment ...
Ultrasonographic Assessment of Neck Muscular Size and Range of Motion in Rugby Players![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
28 février 2018, HEMELRYCK, Walter; Calistri, Josselin; Dugardeyn, Christian; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Background: World Rugby Union laws are constantly evolving towards stringent injury-prevention, particularly for contested scrums, since front row players are most at risk of cervical spine injuries. Recently, some countries have also introduced tailored training programs and minimum performance requirements for playing in the front row. Nevertheless, these approaches lack an objective assessment ...
The Normobaric Oxygen Paradox-Hyperoxic Hypoxic Paradox: A Novel Expedient Strategy in Hematopoiesis Clinical Issues![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
janvier 2023, Salvagno, Michele; Coppalini, Giacomo; Taccone, Fabio-Silvio; Strapazzon, Giacomo; Mrakic-Sposta, Simona; Rocco, Monica; Khalife, Maher; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Hypoxia, even at non-lethal levels, is one of the most stressful events for all aerobic organisms as it significantly affects a wide spectrum of physiological functions and energy production. Aerobic organisms activate countless molecular responses directed to respond at cellular, tissue, organ, and whole-body levels to cope with oxygen shortage allowing survival, including enhanced neo-angiogenesis ...
The effect of pre-dive ingestion of dark chocolate on endothelial function after a scuba dive![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
15 mars 2015, THEUNISSEN, Sigrid; BALESTRA, Costantino
; BOUTROS, Antoine; De Bels, David; Guerrero, François; GERMONPRÉ, Peter,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Objective: The aim of the study was to observe the effects of dark chocolate on endothelial function after scuba diving.
Methods: Forty-two male scuba divers were divided into two groups: a control (n=21) and a chocolate group (n=21). They performed a 33-metres deep scuba-air dive for 20 minutes in a diving pool (Nemo 33, Brussels). Water temperature was 33⁰C. The chocolate group ingested 30 g ...
The effect of a passive stretch training protocol on performance during a drop jump in humans![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
30 mars 2013, Levenez, Morgan; THEUNISSEN, Sigrid; Bottero, Antoine; SNOECK, Thyl; Tinlot, Arnaud; BALESTRA, Costantino
; Provyn, Steven,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Our study's aim is to show how a five-week stretch training protocol, based on passive stretching, can change muscle performance during a drop jump (stretch shortening cycle). METHODS: This study observes in 8 healthy subjects (four males and four females), the effect of a 5-week passive stretch training protocol on the stretch shortening cycle (SSC) during the performance of a drop jump, and identify ...
The effect of a passive stretch training protocol on performance during a drop jump in humans![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
15 juin 2013, Lévénez, Morgan; THEUNISSEN, Sigrid; Bottero, Antoine; SNOECK, Thyl; Bruyère, A; Tinlot, Arnaud; BALESTRA, Costantino
; Provyn, Steven,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Aim: Our study's aim is to show how a five-week stretch training protocol, based on passive stretching, can change muscle performance during a drop jump (stretch shortening cycle).
Methods: This study observes in 8 healthy subjects (four males and four females), the effect of a 5-week passive stretch training protocol on the stretch shortening cycle (SSC) during the performance of a drop jump, ...
The 'normobaric oxygen paradox': does it increase haemoglobin?![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
14 juin 2012, De Bels, David; THEUNISSEN, Sigrid; Devriendt, Jacques; GERMONPRÉ, Peter; Lafère, Pierre; Valsamis, Joseph; SNOECK, Thyl; Meeus, Philippe; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Background: A novel approach to increasing erythropoietin (EPO) using oxygen (O2) (the 'normobaric oxygen paradox') has been reported in healthy volunteers. We investigated whether the EPO increase is sufficient to induce erythropoiesis by comparing two protocols of O2 administration.
Methods: We compared the effect of daily versus alternate days 100% O2, breathed for 30 minutes, on haemoglobin ...
The "ON-OFF" Switching Response of Reactive Oxygen Species in Acute Normobaric Hypoxia: Preliminary Outcome![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
16 février 2023, BALESTRA, Costantino
; Mrakic-Sposta, Simona; Gussoni, Maristella; Marzorati, Mauro; Porcelli, Simone; Bosco, Gerardo; Montorsi, Michela; Lafortuna, Claudio; Vezzoli, Alessandra,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Exposure to acute normobaric hypoxia (NH) elicits reactive oxygen species (ROS) accumulation, whose production kinetics and oxidative damage were here investigated. Nine subjects were monitored while breathing an NH mixture (0.125 F(I)O(2) in air, about 4100 m) and during recovery with room air. ROS production was assessed by Electron Paramagnetic Resonance in capillary blood. Total antioxidant ...
The "normobaric oxygen paradox": a new tool for the anesthetist?![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
10 janvier 2014, Rocco, Monica; Ditri, Luciano; De Bels, David; Corazza, Francis; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Hypoxia is the natural trigger for endogenous EPO production but recently the use of intermittent hyperoxia to stimulate EPO has been postulated and this phenomenon has been called the "normobaric oxygen paradox" (NOP). The "NOP" is a mechanism by which oxygen regulates the expression of the Hypoxia Inducible Factor 1 alpha (HIF-1alpha). The HIF-1alpha-depending gene regulation is responsible for ...
Static Metabolic Bubbles as Precursors of Vascular Gas Emboli During Divers' Decompression: A Hypothesis Explaining Bubbling Variability![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
30 juillet 2019, Imbert, Jean Pierre; Egi, Salih Murat; GERMONPRÉ, Peter; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Introduction: The risk for decompression sickness (DCS) after hyperbaric exposures (such as SCUBA diving) has been linked to the presence and quantity of vascular gas emboli (VGE) after surfacing from the dive. These VGE can be semi-quantified by ultrasound Doppler and quantified via precordial echocardiography. However, for an identical dive, VGE monitoring of divers shows variations related to ...
Spirometry and oxidative stress after rebreather diving in warm water![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
05 août 2018, Bosco, Gerardo; Quartesan, Silvia; Mrakic-Sposta, Simona; Moretti, Sarah; BALESTRA, Costantino
; Rubini, Alessandro,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Introduction: Hyperbaric oxygen (HBO(2)) therapy and use of enriched air can result in oxidative injury affecting the brain, lungs and eyes. HBO(2) exposure during diving can lead to a decrease in respiratory parameters. However, the possible effects of acute exposure to oxygen-enriched diving on subsequent spirometric performance and oxidative state in humans have not been recently described recently. ...
Relationships between plasma lipids, proteins, surface tension and post-dive bubbles![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
13 février 2015, Schellart, Nico; Rozloznik, Miroslav; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Decompression sickness (DCS) in divers is caused by bubbles of inert gas. When DCS occurs, most bubbles can be found in the venous circulation: venous gas emboli (VGE). Bubbles are thought to be stabilized by low molecular weight surfactant reducing the plasma-air surface tension (γ). Proteins may play a role as well. We studied the interrelations between these substances, γ and VGE, measured before ...
Relationships between plasma lipids, proteins, surface tension and post-dive bubbles![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
13 février 2015, Schellaert, Nicolas; Rolzoznik, Miroslav; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Decompression sickness (DCS) in divers is caused by bubbles of inert gas. When DCS occurs, most bubbles can be found in the venous circulation: venous gas emboli (VGE). Bubbles are thought to be stabilized by low molecular weight surfactant reducing the plasma-air surface tension (γ). Proteins may play a role as well. We studied the interrelations between these substances, γ and VGE, measured before ...
Qu'est-ce qui va changer? - Capitre dans Coeur et Plongée![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
Livre/Ouvrage ou monographie
Le monde sous-marin est devenu accessible au plus grand nombre. Les méthodes de plongée se sont diversifiées, la population de plongeurs aussi... Mais la plongée demeure une activité à risques. Les pathologies cardiaques peuvent faire courir des dangers importants, non seulement au plongeur, mais aussi à tous ceux impliqués en cas d'assistance. Or, les données concernant les décès en plongée mettent ...
Pulmonary Effects of One Week of Repeated Recreational Closed-Circuit Rebreather Dives in Cold Water![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
28 décembre 2022, Gouin, Emmanuel; BALESTRA, Costantino
; Orsat, Jeremy; Dugrenot, Emmanuel; L'Her, Erwan,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Background and Objectives: The use of closed-circuit rebreathers (CCRs) in recreational diving is gaining interest. However, data regarding its physiological effects are still scarce. Immersion, cold water, hyperoxia, exercise or the equipment itself could challenge the cardiopulmonary system. The purpose of this study was to examine the impact of CCR diving on lung function and autonomous cardiac ...
Preconditioning to Reduce Decompression Stress in Scuba Divers![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
Article scientifique
BACKGROUND: Using ultrasound imaging, vascular gas emboli (VGE) are observed after asymptomatic scuba dives and are considered a key element in the potential development of decompression sickness (DCS). Diving is also accompanied with vascular dysfunction, as measured by flow-mediated dilation (FMD). Previous studies showed significant intersubject variability to VGE for the same diving exposure and ...
Pre-dive Whole-Body Vibration Better Reduces Decompression-Induced Vascular Gas Emboli than Oxygenation or a Combination of Both![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
30 novembre 2016, BALESTRA, Costantino
; THEUNISSEN, Sigrid; Papadopoulou, Virginie; Le Mener, Cédric; GERMONPRÉ, Peter; Guerrero, François; Lafère, Pierre,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Purpose: Since non-provocative dive profiles are no guarantor of protection against decompression sickness, novel means including pre-dive "preconditioning" interventions, are proposed for its prevention. This study investigated and compared the effect of pre-dive oxygenation, pre-dive whole body vibration or a combination of both on post-dive bubble formation. Methods: Six healthy volunteers performed ...
Pre-dive Whole-Body Vibration Better Reduces Decompression-Induced Vascular Gas Emboli than Oxygenation or a Combination of Both![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
17 février 2015, Cavalade, Maxence; Papadopoulou, Virginie; THEUNISSEN, Sigrid; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Purpose: The purpose of this study was (1) to further explore the heart rate dynamics and assess a potential cardiovascular risk in response to 4000 m jumps in experienced skydivers; (2) to assess whether there is an impact of such jumps on skydivers' cortical arousal or not, which may impact their decision making processes.
Method: 18 experienced skydivers performed successive jumps from a plane ...
Physiology of repeated mixed gas 100-m wreck dives using a closed-circuit rebreather: a field bubble study![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
28 novembre 2021, BALESTRA, Costantino
; Guerrero, François; THEUNISSEN, Sigrid; GERMONPRÉ, Peter; Lafère, Pierre,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Purpose: Data regarding decompression stress after deep closed-circuit rebreather (CCR) dives are scarce. This study aimed to monitor technical divers during a wreck diving expedition and provide an insight in venous gas emboli (VGE) dynamics.
Methods: Diving practices of ten technical divers were observed. They performed a series of three consecutive daily dives around 100 m. VGE counts were ...
Physiological characteristics associated with increased resistance to decompression sickness in male and female rats![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
23 juillet 2020, Lautridou, Jacky; Dugrenot, Emmanuel; Amérand, Aline; Guernec, Anthony; Pichavant-Rafini, Karine; Gouvanec, Christelle; Inizan, Manon; Albacete, Gaelle; Belhomme, Marc; Galinat, Hubert; Lafère, Pierre; BALESTRA, Costantino
; Guerrero, François; Moisan, Chistine; Buzzacott, Peter,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Decompression sickness (DCS) is a complex and poorly understood systemic disease with wide inter-individual resistance variability. We selectively bred rats with a 3-fold greater resistance to DCS than standard ones. To investigate possible physiological mechanisms underlying the resistance to DCS, including sex-related differences in these mechanisms, 15 males and 15 females resistant to DCS were ...
Physiological and Clinical Impact of Repeated Inhaled Oxygen Variation on Erythropoietin Levels in Patients After Surgery![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
15 septembre 2021, Khalifé, Maher; Ben Haziz, Mohamed; BALESTRA, Costantino
; Valsamis, Joseph; Sosnowski, Maurice,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
The "Normobaric Oxygen Paradox" (NOP) is a physiologic mechanism that induces an increase of endogenous erythropoietin (EPO) production by creating a state of relative hypoxia in subjects previously exposed to hyperoxia, followed by a rapid return to normoxia. Oxygen exposure duration and inspired oxygen fraction required to observe a significant increase in EPO or hemoglobin are not clearly defined. ...
Patent Foramen Ovale (PFO), Personality Traits, and Iterative Decompression Sickness. Retrospective Analysis of 209 Cases![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
20 août 2017, Lafère, Pierre; BALESTRA, Costantino
; Caers, Dirk; GERMONPRÉ, Peter,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Introduction: There is a need to evaluate the influence of risk factors such as patency of foramen ovale (PFO) or "daredevil" psychological profile on contra-indication policy after a decompression sickness (DCS). Methods: By crossing information obtained from Belgian Hyperbaric Centers, DAN Emergency Hotline, the press, and Internet diving forums, it was possible to be accountable for the majority ...
Oxygen Variations-Insights into Hypoxia, Hyperoxia and Hyperbaric Hyperoxia - Is the Dose the Clue?![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
20 septembre 2023, BALESTRA, Costantino
; Mrakic-Sposta, Simona; Virgili, Fabio,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
on, nitrogen and hydrogen); aerobic organisms depend on it to release energy from carbon-based molecules. The concentration of oxygen in the atmosphere is ~20.93–20.95% (209–460 ppm), but this has fluctuated markedly throughout geological history. It stabilized within a habitable range, between ~15% and 35%, which has been maintained from the Cambrian period 540 million years ago until today [1].
The ...
Oxygen Variations![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
26 septembre 2023, BALESTRA, Costantino
; Virgili, Fabio; Mrakic-Sposta, Simona,
- HE Bruxelles Brabant
,
- Livre/Ouvrage ou monographie
Livre/Ouvrage ou monographie
For many years, diving and hyperbaric medicine has strived to increase our understanding of the effects of environmental stressors on human pathophysiology. It has demonstrated the importance of oxygen and has taught us not to fear this oxidative molecule, the name of which is derived from the ancient Greek meaning the “acid generator” or Oxy-Gene; indeed, at that time, it was believed that all acids ...
Oxidative Stress Response’s Kinetics after 60 Minutes at Different (30% or 100%) Normobaric Hyperoxia Exposures![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
30 décembre 2022, Leveque, Clément; Mrakic-Sposta, Simona; Lafère, Pierre; Vezzoli, Alessandra; Germonpré, Peter; Beer, Alexandre; Mievis, Stéphane; Virgili, Fabio; LAMBRECHTS, Kate; THEUNISSEN, Sigrid; Guerrero, François; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Oxygen is a powerful trigger for cellular reactions and is used in many pathologies,
including oxidative stress. However, the effects of oxygen over time and at different partial pressures
remain poorly understood. In this study, the metabolic responses of normobaric oxygen intake
for 1 h to mild (30%) and high (100%) inspired fractions were investigated. Fourteen healthy nonsmoking subjects (7 ...
Oxidative Stress Response Kinetics after 60 Minutes at Different Levels (10% or 15%) of Normobaric Hypoxia Exposure![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
15 juin 2023, Leveque, Clément; Mrakic-Sposta, Simona; THEUNISSEN, Sigrid; Germonpré, Peter; LAMBRECHTS, Kate; Vezzoli, Alessandra; Gussoni, Maristella; Levenez, Morgan; Lafère, Pierre; Guerrero, François; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
In this study, the metabolic responses of hypoxic breathing for 1 h to inspired fractions of 10% and 15% oxygen were investigated. To this end, 14 healthy nonsmoking subjects (6 females and 8 males, age: 32.2 ± 13.3 years old (mean ± SD), height: 169.1 ± 9.9 cm, and weight: 61.6 ± 16.2 kg) volunteered for the study. Blood samples were taken before, and at 30 min, 2 h, 8 h, 24 h, and 48 h after a 1 ...
Oxidative Stress Response Kinetics after 60 Minutes at Different (1.4 ATA and 2.5 ATA) Hyperbaric Hyperoxia Exposures![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
02 août 2023, Leveque, Clément; Mrakic-Sposta, Simona; THEUNISSEN, Sigrid; Germonpré, Peter; LAMBRECHTS, Kate; Vezzoli, Alessandra; Bosco, Gerardo; Levenez, Morgan; Lafère, Pierre; Guerrero, François; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Hyperbaric oxygen therapy (HBOT) is a therapeutical approach based on exposure to pure oxygen in an augmented atmospheric pressure. Although it has been used for years, the exact kinetics of the reactive oxygen species (ROS) between different pressures of hyperbaric oxygen exposure are still not clearly evidenced. In this study, the metabolic responses of hyperbaric hyperoxia exposures for 1 h at ...
Oxidative stress in breath-hold divers after repetitive dives![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
08 juin 2013, THEUNISSEN, Sigrid; Sponciello, Nicholas; Rozloznik, Miroslav; GERMONPRÉ, Peter; Guerrero, François; Cialoni, Danilo; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Introduction: Hyperoxia causes oxidative stress. Breath-hold diving is associated with transient hyperoxia followed by hypoxia and a build-up of carbon dioxide (CO₂), chest-wall compression and significant haemodynamic changes. This study analyses variations in plasma oxidative stress markers after a series of repetitive breath-hold dives.
Methods: Thirteen breath-hold divers were asked to perform ...
One-week cocoa flavanol intake increases prefrontal cortex oxygenation at rest and during moderate-intensity exercise in normoxia and hypoxia![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
12 juillet 2018, Decroix, Lieselot; Tonoli, Cajsa; Lespagnol, Elodie; BALESTRA, Costantino
; Descat, Amandine; Drittij-Reijnders, Marie José; Blackwell, Jamie; Stahl, Wilhelm; Jones, Andrew; Wesseler, Antje; Bast, Aalt; Meeusen, Romain; Heyman, Elsa,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
During exercise in hypoxia, O2 delivery to brain and muscle is compromised, and oxidative stress is elicited. Cocoa flavanols (CF) have antioxidant capacities and can increase blood flow by stimulating endothelial function. We aimed to examine the effects of 7-day CF intake on oxidative stress, nitric oxide production, and tissue oxygenation in response to exercise in normobaric hypoxia (14.3% O2). ...
Objective vs. Subjective Evaluation of Cognitive Performance During 0.4-MPa Dives Breathing Air or Nitrox![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
19 avril 2017, GERMONPRÉ, Peter; BALESTRA, Costantino
; Hemelryck, Walter; Buzzacott, Peter; Lafère, Pierre,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
BACKGROUND: Divers try to limit risks associated with their sport, for instance by breathing enriched air nitrox (EANx) instead of air. This double blinded, randomized trial was designed to see if the use of EANx could effectively improve cognitive performance while diving. METHODS: Eight volunteers performed two no-decompression dry dives breathing air or EANx for 20 min at 0.4 MPa. Cognitive ...
Nitric oxide-related endothelial changes in breath-hold and scuba divers![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
01 mars 2013, THEUNISSEN, Sigrid; Guerrero, François; Sponciello, Nicholas; Cialoni, Danilo; Pieri, Massimo; GERMONPRÉ, Peter; Obeid, Georges; Tillmans, Frauke; Papadopoulou, Virginie; HEMELRYCK, Walter; Marroni, Alessandro; De Bels, David; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Objective: Scuba and breath-hold divers are compared to investigate whether endothelial response changes are similar despite different exposure(s) to hyperoxia.
Design: 14 divers (nine scuba and five breath-holding) performed either one scuba dive (25m/25 minutes) or successive breath-hold dives at a depth of 20 meters, adding up to 25 minutes of immersion time in a diving pool. Flow-mediated ...
Mini Trampoline, a New and Promising Way of SCUBA Diving Preconditioning to Reduce Vascular Gas Emboli?![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
29 avril 2022, LAMBRECHTS, Kate; GERMONPRÉ, Peter; Vandenheede, Joaquim; Delorme, Manon; Lafere, Pierre; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Background: Despite evolution in decompression algorithms, decompression illness is still an issue nowadays. Reducing vascular gas emboli (VGE) production or preserving endothelial function by other means such as diving preconditioning is of great interest. Several methods have been tried, either mechanical, cardiovascular, desaturation aimed or biochemical, with encouraging results. In this study, ...
Les effets du crochetage myo-aponévrotique sur l’architecture et les propriétés intrinsèques du muscle gastrocnemius medialis à l’étirement![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
20 septembre 2018, Vigouroux, Florent; Levenez, Morgan; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Background : this study investigates the effects of the diacutaneous
myo-aponeurosis fibrolysis technique, also called
hook treatment, on the architectural and mechanical aspects
of the muscle.
Methods : the overall muscle-tendon unit passive tension and
range of motion and muscle architecture of the medial gastrocnemius
(fascicle length and pennation angle), as well as
mechanical intrinsic ...
Investigating critical flicker fusion frequency for monitoring gas narcosis in divers![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
17 décembre 2020, Vrijdag, Xavier; Van Waart, Hanna; Sleigh, Jaimie; BALESTRA, Costantino
; Mitchell, Simon,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
INTRODUCTION: Critical flicker fusion frequency (CFFF) has been used in various studies to measure the cognitive effects of gas mixtures at depth, sometimes with conflicting or apparently paradoxical results. This study aimed to evaluate a novel automatic CFFF method and investigate whether CFFF can be used to monitor gas-induced narcosis in divers. METHODS: Three hyperbaric chamber experiments were ...
Inert gas narcosis in scuba diving, different gases different reactions![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
19 avril 2019, Rocco, Monica; Pelaia, Paolo; Di Benedetto, Pia; Conte, Giuseppe; Maggi, Luigi; Fiorelli, Silvia; Mercieri, Marco; BALESTRA, Costantino
; de Biasi, Roberto Alberto,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Purpose Underwater divers face several potential neurological hazards when breathing compressed gas mixtures including nitrogen narcosis which can impact diver’s safety. Various human studies have clearly demonstrated brain impairment due to nitrogen narcosis in divers at 4 ATA using critical flicker fusion frequency (CFFF) as a cortical performance indicator. However, recently some authors have ...
Increasing Oxygen Partial Pressures Induce a Distinct Transcriptional Response in Human PBMC: A Pilot Study on the “Normobaric Oxygen Paradox”![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
05 janvier 2021, Fratantonio, Deborah; Virgili, Fabio; Zucchi, Alessandro; LAMBRECHTS, Kate; Latronico, Tiziana; Lafère, Pierre; Germonpré, Pierre; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
The term "normobaric oxygen paradox" (NOP), describes the response to the return to normoxia after a hyperoxic event, sensed by tissues as oxygen shortage, and resulting in up-regulation of the Hypoxia-inducible factor 1alpha (HIF-1alpha) transcription factor activity. The molecular characteristics of this response have not been yet fully characterized. Herein, we report the activation time trend ...
Hyperoxia Alters Ultrastructure and Induces Apoptosis in Leukemia Cell Lines![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
12 février 2020, De Bels, David; Tillmans, Frauke; Corazza, Francis; Bizzarri, Mariano; GERMONPRÉ, Peter; Radermacher, Peter; Keziban, Gunce-Orman; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Oxygenation conditions are crucial for growth and tumor progression. Recent data suggests a decrease in cancer cell proliferation occurring after exposure to normobaric hyperoxia. Those changes are associated with fractal dimension. The purpose of this research was to study the impact of hyperoxia on apoptosis and morphology of leukemia cell lines. Two hematopoietic lymphoid cancer cell lines (a ...
Hyperbaric medicine![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
12 février 2023, BALESTRA, Costantino
; Kot, Jacek,
- HE Bruxelles Brabant
,
- Livre/Ouvrage ou monographie
Livre/Ouvrage ou monographie
Oxygen (both its presence and absence) acts as a potent signaling mechanism in many, if not
most, cellular processes.
Oxygen has been used therapeutically mainly to alleviate or correct hypoxia, and has been
administered in supra-atmospheric doses in the form of hyperbaric oxygen (a method derived from
diving medicine practices, but has been used in non-diving applications since the 1960s).
Hyperbaric ...
Hydration status during commercial saturation diving measured by bioimpedance and urine specific gravity![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
29 septembre 2022, Werke, Stian Lande; Landswerk, Halvor Dagsson; Lautridou, Jacky; Imbert, Jean-Pierre; BALESTRA, Costantino
; Eftedal, Ingrid,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Excessive fluid loss triggered by hyperbaric pressure, water immersion and hot water suits causes saturation divers to be at risk of dehydration. Dehydration is associated with reductions in mental and physical performance, resulting in less effective work and an increased risk of work-related accidents. In this study we examined the hydration status of 11 male divers over 19 days of a commercial ...
Hemoglobin and Erythropoietin After Commercial Saturation Diving![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
21 août 2018, Kiboub, Fatima Zohra; BALESTRA, Costantino
; Loennechen, Øyvind; Eftedal, Ingrid,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Saturation divers are exposed to elevated partial pressure of oxygen (ppO2) in their hyperbaric work environment. Experimental studies indicate that oxygen transport is altered, and we have previously reported a drop in hematocrit and extensive downregulation of genes involved in blood oxygen transport capacity after decompression from professional saturation diving. Here we investigate the initial ...
Heart Rate Variability During a Standard Dive: A Role for Inspired Oxygen Pressure?![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
13 août 2021, Lafère, Pierre; LAMBRECHTS, Kate; GERMONPRÉ, Peter; Balestra, Ambre; Germonpré, Faye-Lisa; Marroni, Alessandro; Cialoni, Danilo; Bosco, Gerardo; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Introduction: Heart rate variability (HRV) during underwater diving has been infrequently investigated because of environment limitations and technical challenges. This study aims to analyze HRV changes while diving at variable hyperoxia when using open circuit (OC) air diving apparatus or at constant hyperoxia using a closed-circuit rebreather (CCR). We used HRV analysis in time and frequency domain ...
Heart Rate Variability During a Standard Dive: A Role for Inspired Oxygen Pressure?![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
13 août 2021, Lafère, Pierre; LAMBRECHTS, Kate; GERMONPRÉ, Peter; BALESTRA, Ambre; Germonpré, Faye-Lisa; Marroni, Alessandro; Cialoni, Danilo; Bosco, Gerardo; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Introduction: Heart rate variability (HRV) during underwater diving has been infrequently investigated because of environment limitations and technical challenges. This study aims to analyze HRV changes while diving at variable hyperoxia when using open circuit (OC) air diving apparatus or at constant hyperoxia using a closed-circuit rebreather (CCR). We used HRV analysis in time and frequency domain ...
Full-Face Mask Use during SCUBA Diving Counters Related Oxidative Stress and Endothelial Dysfunction![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
15 janvier 2022, Levenez, Morgan; LAMBRECHTS, Kate; Mrakic-Sposta, Simona; Vezzoli, Alessandra; Germonpré, Peter; Pique, Hadrien; Virgili, Fabi; Bosco, Gerardo; Lafere, Pierre; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Impaired flow mediated dilation (FMD), an index of vascular stress, is known after SCUBA diving. This is related to a dysfunction of nitric oxide (NO) availability and a disturbance of the redox status, possibly induced by hyperoxic/hyperbaric gas breathing. SCUBA diving is usually performed with a mask only covering "half face" (HF) and therefore forcing oral breathing. Nasal NO production is ...
Flying after diving: should recommendations be reviewed? In-flight echocardiographic study in bubble-prone and bubble-resistant divers![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
13 mai 2015, Cialoni, Danilo; Pieri, Massimo; BALESTRA, Costantino
; Marroni, Alessandro,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
INTRODUCTION: Inert gas accumulated after multiple recreational dives can generate tissue supersaturation and bubble formation when ambient pressure decreases. We hypothesized that this could happen even if divers respected the currently recommended 24-hour pre-flight surface interval (PFSI). METHODS: We performed transthoracic echocardiography (TTE) on a group of 56 healthy scuba divers (39 male, ...
Field study of anthropomorphic and muscle performance changes among elite skippers following a transoceanic race![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
12 juin 2020, Lafère, Pierre; Gatzoff, Yann; Guerrero, François; Provyn, Steven; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
BACKGROUND: Ocean racing has become increasingly demanding, both physically and psychologically. The aim of the study was to assess global changes after a transoceanic race. MATERIALS AND METHODS: Eight male sailors were evaluated pre- and post-race through anthropometric measurements (weight, skinfold, girth at different level and estimated body fat percentage), multifrequency tetrapolar bioelectrical ...
Feasibility of Detecting Brain Areas Involved in Extreme Breath-Hold Diving![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
20 janvier 2021, Jissendi-Tchofo, Patrice; Jdaoudi, Yassin; GERMONPRÉ, Peter; Brizzolari, Andrea; Musimu, Patrick; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
We report Blood Oxygen Level Dependent (BOLD) signal changes recorded in the brain of an elite breath-hold diver during voluntary dry long breath-hold by means of fMRI. An independent component analysis (ICA) method was applied to extract brain areas that are putatively involved in the apnea process network. We discuss the hypothesis that these BOLD signal variations express the functional adaptive ...
Extreme Environments in Movement Science and Sport Psychology![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
20 décembre 2018, BALESTRA, Costantino
; Jacek, Kot; Efrati, Shai; Guerrero, François; Blatteau, Jean-Eric; Besnard, Stéphane,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Evidence of Heritable Determinants of Decompression Sickness in Rats![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
22 juillet 2017, Lautridou, Jacky; Buzzacott, Peter; Belhomme, Marc; Dugrenot, Emmanuel; Lafère, Pierre; BALESTRA, Costantino
; Guerrero, François,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
NTRODUCTION: Decompression sickness (DCS) is a complex and poorly understood systemic disease caused by inadequate desaturation following a decrease of ambient pressure. Strong variability between individuals is observed for DCS occurrence. This raises questions concerning factors that may be involved in the inter-individual variability of DCS occurrence. This study aimed to experimentally assess ...
Evaluation of Protection Level, Respiratory Safety, and Practical Aspects of Commercially Available Snorkel Masks as Personal Protection Devices Against Aerosolized Contaminants and SARS-CoV2![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
15 juin 2020, GERMONPRÉ, Peter; Van Rompaeye, Dirk; BALESTRA, Costantino
,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Introduction: The “Severe Acute Respiratory Syndrome Coronavirus 2” (SARS-CoV2) pandemic has led to a worldwide shortage of personal protection devices (PPD) for medical and paramedical personnel. Adaptation of commercially available snorkel masks to serve as full face masks has been proposed. Even not formally approved as PPD, they are publicized on social media as suitable for this use. Concerns ...
Evaluation of Divers' Neuropsychometric Effectiveness and High-Pressure Neurological Syndrome via Computerized Test Battery Package and Questionnaires in Operational Setting![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
12 avril 2019, Berenji Ardestani, Simin; BALESTRA, Costantino
; Bouzinova, Elena; Loennechen, Oyvind,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Introduction: When divers are compressed to water depths deeper than 150 meter sea water (msw), symptoms of high-pressure neurological syndrome (HPNS) might appear due to rapid increase in pressure on the central nervous system during compression. The aim of this study was to first operate a new computerized tool, designed to monitor divers' wellbeing and cognitive function, and to record the results. ...
Elevations of Extracellular Vesicles and Inflammatory Biomarkers in Closed Circuit SCUBA Divers![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
22 mars 2023, Arya, Awadhesh; BALESTRA, Costantino
; Bhopale, Veena; Tominen, Laura; Raisanen-Sokolowski, Anne; Dugrenot, Emmanuel; Thom, Stephen,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Blood-borne extracellular vesicles and inflammatory mediators were evaluated in divers using a closed circuit rebreathing apparatus and custom-mixed gases to diminish some diving risks. "Deep" divers (n = 8) dove once to mean (+/-SD) 102.5 +/- 1.2 m of sea water (msw) for 167.3 +/- 11.5 min. "Shallow" divers (n = 6) dove 3 times on day 1, and then repetitively over 7 days to 16.4 +/- 3.7 msw, for ...
Effects of oxygen-enriched air on cognitive performance during SCUBA-diving - an open-water study![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
12 avril 2017, Brebeck, Anne-Kathrin; Deussen, Andreas; Schmitz-Pfeiffer, Henning; Range, Ursula; BALESTRA, Costantino
; Cleveland, Sinclair; Schipke, Jochen,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Backround: Nitrogen narcosis impairs cognitive function, a fact relevant during SCUBA-diving. Oxygen-enriched air (nitrox) became popular in recreational diving, while evidence of its advantages over air is limited. AIM: Compare effects of nitrox28 and air on two psychometric tests. METHODS: In this prospective, double-blind, open-water study, 108 advanced divers (38 females) were randomized to an ...
Effects of Electrical Stimulation on Delayed Onset Muscle Soreness (DOMS): Evidences from Laboratory and In-Field Studies![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
12 septembre 2023, Gussoni, Maristella; Moretti, Sarah; Vezzoli, Alessandra; Genitoni, Valerio; Giardini, Guido; BALESTRA, Costantino
; Bosco, Gerardo; Pratali, Lorenza; Spagnolo, Elisabetta; Montorsi, Michela; Mrakic-Sposta, Simona,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Intense, long exercise can increase oxidative stress, leading to higher levels of inflammatory
mediators and muscle damage. At the same time, fatigue has been suggested as one of the factors
giving rise to delayed-onset muscle soreness (DOMS). The aim of this study was to investigate the
efficacy of a specific electrical stimulation (ES) treatment (without elicited muscular contraction) on
two ...
Effects of Acute Hypobaric Hypoxia Exposure on Cardiovascular Function in Unacclimatized Healthy Subjects: A "Rapid Ascent" Hypobaric Chamber Study![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
28 avril 2022, THEUNISSEN, Sigrid; BALESTRA, Costantino
; Bolognési, Sébastien; Borgers, Guy; Vissenaeken, Dirk; Obeid, Georges; Germonpré, Peter; Honoré, Patrick M.; De Bels, David,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
Background: This study aimed to observe the effects of a fast acute ascent to simulated high altitudes on cardiovascular function both in the main arteries and in peripheral circulation. Methods: We examined 17 healthy volunteers, between 18 and 50 years old, at sea level, at 3842 m of hypobaric hypoxia and after return to sea level. Cardiac output (CO) was measured with Doppler transthoracic ...
Effect of tetrahydrobiopterin and exercise training on endothelium-dependent vasorelaxation in SHR![Peer reviewed Peer reviewed](/themes/Mirage2//images/peer_review.svg)
02 juin 2013, Guerrero, François; Sanéo, Thioub; Goanvec, Christelle; THEUNISSEN, Sigrid; Feray, Annie; BALESTRA, Costantino
; Mansourati, Jacques,
- HE Bruxelles Brabant
,
- Article scientifique
Article scientifique
We examined whether the improvement of impaired NO-dependent vasorelaxation by exercise training could be mediated through a BH4-dependent mechanism. Male spontaneously hypertensive rats (SHR, n = 20) and Wistar-Kyoto rats (WKY, n = 20) were trained (Tr) for 9 weeks on a treadmill and compared to age-matched sedentary animals (Sed). Endothelium-dependent vasorelaxation (EDV) was assessed with ...