• Dark chocolate reduces endothelial dysfunction after successive breath-hold dives in cool waterPeer reviewedOpen access 

      16 septembre 2013, THEUNISSEN, Sigrid; Schumacker, Julie; Guerrero, François; Tillmans, Frauke; BOUTROS, Antoine; Lambrechts, Kate; Mazur, Alexandra; Pieri, Massimo; GERMONPRÉ, Peter; BALESTRA, Costantino, HE Bruxelles Brabant
      Article scientifique
      Objective: The aim of this study is to observe the effects of dark chocolate on endothelial function after a series of successive apnea dives in non-thermoneutral water. Methods: Twenty breath-hold divers were divided into two groups: a control group (8 males and 2 females) and a chocolate group (9 males and 1 female). The control group was asked to perform a series of dives to 20 m adding up to ...
    • The effect of pre-dive ingestion of dark chocolate on endothelial function after a scuba divePeer reviewedClosed access 

      15 mars 2015, THEUNISSEN, Sigrid; BALESTRA, Costantino; BOUTROS, Antoine; De Bels, David; Guerrero, François; GERMONPRÉ, Peter, HE Bruxelles Brabant
      Article scientifique
      Objective: The aim of the study was to observe the effects of dark chocolate on endothelial function after scuba diving. Methods: Forty-two male scuba divers were divided into two groups: a control (n=21) and a chocolate group (n=21). They performed a 33-metres deep scuba-air dive for 20 minutes in a diving pool (Nemo 33, Brussels). Water temperature was 33⁰C. The chocolate group ingested 30 g ...
    • Effect of tetrahydrobiopterin and exercise training on endothelium-dependent vasorelaxation in SHRPeer reviewedClosed access 

      02 juin 2013, Guerrero, François; Sanéo, Thioub; Goanvec, Christelle; THEUNISSEN, Sigrid; Feray, Annie; BALESTRA, Costantino; Mansourati, Jacques, HE Bruxelles Brabant
      Article scientifique
      We examined whether the improvement of impaired NO-dependent vasorelaxation by exercise training could be mediated through a BH4-dependent mechanism. Male spontaneously hypertensive rats (SHR, n = 20) and Wistar-Kyoto rats (WKY, n = 20) were trained (Tr) for 9 weeks on a treadmill and compared to age-matched sedentary animals (Sed). Endothelium-dependent vasorelaxation (EDV) was assessed with ...
    • Nitric oxide-related endothelial changes in breath-hold and scuba diversPeer reviewedClosed access 

      01 mars 2013, THEUNISSEN, Sigrid; Guerrero, François; Sponciello, Nicholas; Cialoni, Danilo; Pieri, Massimo; GERMONPRÉ, Peter; Obeid, Georges; Tillmans, Frauke; Papadopoulou, Virginie; HEMELRYCK, Walter; Marroni, Alessandro; De Bels, David; BALESTRA, Costantino, HE Bruxelles Brabant
      Article scientifique
      Objective: Scuba and breath-hold divers are compared to investigate whether endothelial response changes are similar despite different exposure(s) to hyperoxia. Design: 14 divers (nine scuba and five breath-holding) performed either one scuba dive (25m/25 minutes) or successive breath-hold dives at a depth of 20 meters, adding up to 25 minutes of immersion time in a diving pool. Flow-mediated ...
    • Oxidative stress in breath-hold divers after repetitive divesPeer reviewedClosed access 

      08 juin 2013, THEUNISSEN, Sigrid; Sponciello, Nicholas; Rozloznik, Miroslav; GERMONPRÉ, Peter; Guerrero, François; Cialoni, Danilo; BALESTRA, Costantino, HE Bruxelles Brabant
      Article scientifique
      Introduction: Hyperoxia causes oxidative stress. Breath-hold diving is associated with transient hyperoxia followed by hypoxia and a build-up of carbon dioxide (CO₂), chest-wall compression and significant haemodynamic changes. This study analyses variations in plasma oxidative stress markers after a series of repetitive breath-hold dives. Methods: Thirteen breath-hold divers were asked to perform ...
    • Simulated air dives induce superoxide, nitric oxide, peroxynitrite, and Ca 2+ alterations in endothelial cellsPeer reviewedClosed access 

      03 avril 2019, Wang, Qiong; Guerrero, François; LAMBRECHTS, Kate; Theron, Michaël, HE Bruxelles Brabant
      Article scientifique
      Human diving is known to induce endothelial dysfunction. The aim of this study was to decipher the mechanism of ROS production during diving through the measure of mitochondrial calcium concentration, peroxynitrite, NO°, and superoxide towards better understanding of dive-induced endothelial dysfunction. Air diving simulation using bovine arterial endothelial cells (compression rate 101 kPa/min to ...