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Colonic Fermentation Promotes Decompression sickness in Rats
08 février 2016, Demaistre, Sébastien; Vallée, Nicolas; Gempp, Emmanuel; LAMBRECHTS, Kate; Louge, Pierre; Duchamp, Claude; Blatteau, Jean-Eric, HE Bruxelles BrabantArticle scientifiqueMassive bubble formation after diving can lead to decompression sickness (DCS). During dives with hydrogen as a diluent for oxygen, decreasing the body's H2 burden by inoculating hydrogen-metabolizing microbes into the gut reduces the risk of DCS. So we set out to investigate if colonic fermentation leading to endogenous hydrogen production promotes DCS in fasting rats. Four hours before an experimental ... -
Coping With Extreme Environments: A Physiological/Psychological Approach
25 juin 2019, BALESTRA, Costantino; Kot, Jacek; Efrati, Shai; Guerrero, François; Blatteau, Jean-Eric; Besnard, Stéphane, HE Bruxelles BrabantArticle scientifique -
Extreme Environments in Movement Science and Sport Psychology
20 décembre 2018, BALESTRA, Costantino; Jacek, Kot; Efrati, Shai; Guerrero, François; Blatteau, Jean-Eric; Besnard, Stéphane, HE Bruxelles BrabantArticle scientifique -
Factors influencing the severity of long-term sequelae in fishermen-divers with neurological decompression sickness
Article scientifiqueIntroduction: Numerous studies have been conducted to identify the factors influencing the short-term prognosis for neurological decompression sickness (DCS). However, the long-term sequelae are rarely assessed. The purpose of this study to investigate the factors likely to influence the long-term prognosis. Methods: Twenty-seven Vietnamese fishermen-divers who on average 9 (SD 6) years beforehand ... -
Fluoxetine Protection in Decompression Sickness in Mice is Enhanced by Blocking TREK-1 Potassium Channel with the "spadin" Antidepressant
16 février 2016, Vallée, Nicolas; LAMBRECHTS, Kate; De Maistre, Sébastien; Royal, Perrine; Mazella, Jean; Borsotto, Marc; Heurteaux, Catherine; Abraini, Jacques; RIsso, Jean-Jacques; Blatteau, Jean-Eric, HE Bruxelles BrabantArticle scientifiqueIn mice, disseminated coagulation, inflammation, and ischemia induce neurological damage that can lead to death. These symptoms result from circulating bubbles generated by a pathogenic decompression. Acute fluoxetine treatment or the presence of the TREK-1 potassium channel increases the survival rate when mice are subjected to an experimental dive/decompression protocol. This is a paradox because ... -
Fluoxetine stimulates anti-inflammatory IL-10 cytokine production and attenuates sensory deficits in a rat model of decompression sickness
22 octobre 2015, Blatteau, Jean-Eric; De Maistre, Sébastien; LAMBRECHTS, Kate; Abraini, Jacques; Risso, Jean-Jacques; Vallée, Nicolas, HE Bruxelles BrabantArticle scientifiqueDespite "gold standard" hyperbaric oxygen treatment, 30% of patients suffering from neurological decompression sickness still exhibit incomplete recovery, including sensory impairments. Fluoxetine, a well-known antidepressant, is recognized as having anti-inflammatory effects in the setting of cerebral ischemia. In this study, we focused on the assessment of sensory neurological deficits and measurement ... -
Tirofiban, a Glycoprotein IIb/IIIa Antagonist, Has a Protective Effect on Decompression Sickness in Rats: Is the Crosstalk Between Platelet and Leukocytes Essential?
11 juillet 2018, LAMBRECHTS, Kate; Demaistre, Sébastien; Blatteau, Jean-Eric; Risso, Jean-Jacques; Vallée, Nicolas, HE Bruxelles BrabantArticle scientifiqueIn its severest forms, decompression sickness (DCS) may extend systemically and/or induce severe neurological deficits, including paralysis or even death. It seems that the sterile and ischemic inflammatory phenomena are consecutive to the reaction of the bubbles with the organism and that the blood platelet activation plays a determinant role in the development of DCS. According to the hypotheses ...