Parcourir HE2B - HE par auteur "Buzzacott, Peter"
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Age, weight and decompression sickness in rats
16 mars 2016, HE Bruxelles BrabantArticle scientifiqueObjective: The aim of this study was to determine if, after controlling for weight, age is associated with decompression sickness (DCS) in rats. Methods: Following compression-decompression, male rats aged 11 weeks were observed for DCS. After two weeks recovery, surviving rats were re-dived using the same compression-decompression profile. Results: In this experiment, there was a clear difference ... -
Effect of a single, open-sea, air scuba dive on human micro- and macrovascular function
15 août 2013, ; Pontier, Jean-Michel; BALESTRA, Costantino
; Mazur, Aleksandra; Wang, Qiong; Buzzacott, Peter; Theron, Michaël; Mansourati, Jacques; Guerrero, François, HE Bruxelles Brabant
Article scientifiquePurpose: Previous studies have shown that bubble formation induced endothelial damage on conduit arteries. We aim to evaluate the effect of diving on microvascular and macrovascular function. Methods: Nine divers took part in a SCUBA dive at 30 msw (400 kPa), for 30 min of bottom time. Pre- and post-dive, they underwent an assessment of endothelial-dependent (acetylcholine) and endothelial-independent ... -
Effect of decompression-induced bubble formation on highly trained divers microvascular function
07 novembre 2013, HE Bruxelles BrabantArticle scientifiqueWe previously showed microvascular alteration of both endothelium-dependent and -independent reactivity after a single SCUBA dive. We aimed to study mechanisms involved in this postdive vascular dysfunction. Ten divers each completed three protocols: (1) a SCUBA dive at 400 kPa for 30 min; (2) a 41-min duration of seawater surface head immersed finning exercise to determine the effect of immersion ... -
Effect of simulated air dive and decompression sickness on the plasma proteome of rats
12 avril 2016, HE Bruxelles BrabantArticle scientifiquePurpose: Decompression sickness (DCS) is a poorly understood systemic disease caused by inadequate desaturation following a reduction in ambient pressure. Although recent studies highlight the importance of circulating factors, the available data are still puzzling. In this study, we aimed to identify proteins and biological pathways involved in the development of DCS in rats. Experimental design: ... -
Effect of splenectomy on platelet activation and decompression sickness outcome in a rat model of decompression
01 septembre 2014, HE Bruxelles BrabantArticle scientifiqueIntroduction: Splenic platelets have been recognized to have a greater prothrombotic potential than others platelets. We studied whether platelets released by splenic contraction could influence the severity and outcome of decompression sickness (DCS) and bubble-induced platelet activation. Methods: Sixteen, male Sprague-Dawley rats were randomly assigned to either a control or a splenectomized ... -
Evidence of Heritable Determinants of Decompression Sickness in Rats
22 juillet 2017, Lautridou, Jacky; Buzzacott, Peter; Belhomme, Marc; Dugrenot, Emmanuel; Lafère, Pierre; BALESTRA, Costantino; Guerrero, François, HE Bruxelles Brabant
Article scientifiqueNTRODUCTION: Decompression sickness (DCS) is a complex and poorly understood systemic disease caused by inadequate desaturation following a decrease of ambient pressure. Strong variability between individuals is observed for DCS occurrence. This raises questions concerning factors that may be involved in the inter-individual variability of DCS occurrence. This study aimed to experimentally assess ... -
Influence of decompression sickness on vasocontraction of isolated rat vessels
18 février 2015, HE Bruxelles BrabantArticle scientifiqueStudies conducted in divers indicate that endothelium function is impaired following a dive even without decompression sickness (DCS). Our previous experiment conducted on rat isolated vessels showed no differences in endothelium-dependent vasodilation after a simulated dive even in the presence of DCS, while contractile response to phenylephrine was progressively impaired with increased decompression ... -
Mechanism of action of antiplatelet drugs on decompression sickness in rats: a protective effect of anti-GPIIbIIIa therapy
15 mai 2015, HE Bruxelles BrabantArticle scientifiqueLiterature highlights the involvement of disseminated thrombosis in the pathophysiology of decompression sickness (DCS). We examined the effect of several antithrombotic treatments targeting various pathways on DCS outcome: acetyl salicylate, prasugrel, abciximab, and enoxaparin. Rats were randomly assigned to six groups. Groups 1 and 2 were a control nondiving group (C; n = 10) and a control diving ... -
Objective vs. Subjective Evaluation of Cognitive Performance During 0.4-MPa Dives Breathing Air or Nitrox
19 avril 2017, ; BALESTRA, Costantino; Hemelryck, Walter; Buzzacott, Peter; Lafère, Pierre, HE Bruxelles Brabant
Article scientifiqueBACKGROUND: Divers try to limit risks associated with their sport, for instance by breathing enriched air nitrox (EANx) instead of air. This double blinded, randomized trial was designed to see if the use of EANx could effectively improve cognitive performance while diving. METHODS: Eight volunteers performed two no-decompression dry dives breathing air or EANx for 20 min at 0.4 MPa. Cognitive ... -
Physiological characteristics associated with increased resistance to decompression sickness in male and female rats
23 juillet 2020, Lautridou, Jacky; Dugrenot, Emmanuel; Amérand, Aline; Guernec, Anthony; Pichavant-Rafini, Karine; Gouvanec, Christelle; Inizan, Manon; Albacete, Gaelle; Belhomme, Marc; Galinat, Hubert; Lafère, Pierre; BALESTRA, Costantino; Guerrero, François; Moisan, Chistine; Buzzacott, Peter, HE Bruxelles Brabant
Article scientifiqueDecompression sickness (DCS) is a complex and poorly understood systemic disease with wide inter-individual resistance variability. We selectively bred rats with a 3-fold greater resistance to DCS than standard ones. To investigate possible physiological mechanisms underlying the resistance to DCS, including sex-related differences in these mechanisms, 15 males and 15 females resistant to DCS were ... -
A ternary model of decompression sickness in rats
01 décembre 2014, Buzzacott, Peter; ; Mazur, Aleksandra; Wang, Qiong; Papadopoulou, Virginie; Theron, Michaël; BALESTRA, Costantino; Guerrero, François, HE Bruxelles Brabant
Article scientifiqueBackground: Decompression sickness (DCS) in rats is commonly modelled as a binary outcome. The present study aimed to develop a ternary model of predicting probability of DCS in rats, (as no-DCS, survivable-DCS or death), based upon the compression/decompression profile and physiological characteristics of each rat. Methods: A literature search identified dive profiles with outcomes no-DCS, ...