Parcourir HE2B - HE par auteur "De Bels, David"
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The effect of pre-dive ingestion of dark chocolate on endothelial function after a scuba dive
15 mars 2015, HE Bruxelles BrabantArticle scientifiqueObjective: The aim of the study was to observe the effects of dark chocolate on endothelial function after scuba diving. Methods: Forty-two male scuba divers were divided into two groups: a control (n=21) and a chocolate group (n=21). They performed a 33-metres deep scuba-air dive for 20 minutes in a diving pool (Nemo 33, Brussels). Water temperature was 33⁰C. The chocolate group ingested 30 g ... -
Effects of Acute Hypobaric Hypoxia Exposure on Cardiovascular Function in Unacclimatized Healthy Subjects: A "Rapid Ascent" Hypobaric Chamber Study
28 avril 2022, HE Bruxelles BrabantArticle scientifiqueBackground: This study aimed to observe the effects of a fast acute ascent to simulated high altitudes on cardiovascular function both in the main arteries and in peripheral circulation. Methods: We examined 17 healthy volunteers, between 18 and 50 years old, at sea level, at 3842 m of hypobaric hypoxia and after return to sea level. Cardiac output (CO) was measured with Doppler transthoracic ... -
Hyperoxia Alters Ultrastructure and Induces Apoptosis in Leukemia Cell Lines
12 février 2020, HE Bruxelles BrabantArticle scientifiqueOxygenation conditions are crucial for growth and tumor progression. Recent data suggests a decrease in cancer cell proliferation occurring after exposure to normobaric hyperoxia. Those changes are associated with fractal dimension. The purpose of this research was to study the impact of hyperoxia on apoptosis and morphology of leukemia cell lines. Two hematopoietic lymphoid cancer cell lines (a ... -
Nitric oxide-related endothelial changes in breath-hold and scuba divers
01 mars 2013, HE Bruxelles BrabantArticle scientifiqueObjective: Scuba and breath-hold divers are compared to investigate whether endothelial response changes are similar despite different exposure(s) to hyperoxia. Design: 14 divers (nine scuba and five breath-holding) performed either one scuba dive (25m/25 minutes) or successive breath-hold dives at a depth of 20 meters, adding up to 25 minutes of immersion time in a diving pool. Flow-mediated ... -
The "normobaric oxygen paradox": a new tool for the anesthetist?
10 janvier 2014, HE Bruxelles BrabantArticle scientifiqueHypoxia is the natural trigger for endogenous EPO production but recently the use of intermittent hyperoxia to stimulate EPO has been postulated and this phenomenon has been called the "normobaric oxygen paradox" (NOP). The "NOP" is a mechanism by which oxygen regulates the expression of the Hypoxia Inducible Factor 1 alpha (HIF-1alpha). The HIF-1alpha-depending gene regulation is responsible for ... -
The 'normobaric oxygen paradox': does it increase haemoglobin?
14 juin 2012, HE Bruxelles BrabantArticle scientifiqueBackground: A novel approach to increasing erythropoietin (EPO) using oxygen (O2) (the 'normobaric oxygen paradox') has been reported in healthy volunteers. We investigated whether the EPO increase is sufficient to induce erythropoiesis by comparing two protocols of O2 administration. Methods: We compared the effect of daily versus alternate days 100% O2, breathed for 30 minutes, on haemoglobin ... -
Variation of Cognitive Function During a Short Stay at Hypobaric Hypoxia Chamber (Altitude: 3842 M)
26 juin 2019, HE Bruxelles BrabantArticle scientifiqueObjective: To observe the effects of a fast-acute ascent to high altitude on brain cognitive function and transcranial doppler parameters in order to understand the physiological countermeasures of hypoxia. Methods: 17 high-altitude-naïve male subjects (mean age was 26.3 ± 8.1 years) participated in the study. We measured Critical Flicker Fusion Frequency (CFFF), blood oxygen saturation, Psychology ...