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    • Increasing Oxygen Partial Pressures Induce a Distinct Transcriptional Response in Human PBMC: A Pilot Study on the “Normobaric Oxygen Paradox”Peer reviewedOpen access 

      05 janvier 2021, Fratantonio, Deborah; Virgili, Fabio; Zucchi, Alessandro; LAMBRECHTS, Kate; Latronico, Tiziana; Lafère, Pierre; Germonpré, Pierre; BALESTRA, Costantino, HE Bruxelles Brabant
      Article scientifique
      The term "normobaric oxygen paradox" (NOP), describes the response to the return to normoxia after a hyperoxic event, sensed by tissues as oxygen shortage, and resulting in up-regulation of the Hypoxia-inducible factor 1alpha (HIF-1alpha) transcription factor activity. The molecular characteristics of this response have not been yet fully characterized. Herein, we report the activation time trend ...