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    • Early Endothelial Dysfunction in Type 1 Diabetes Is Accompanied by an Impairment of Vascular Smooth Muscle Function: A Meta-AnalysisPeer reviewedOpen access 

      05 mai 2020, Lespagnol, Elodie; Dauchet, Luc; Pawlak-Chaouch, Mehdi; BALESTRA, Costantino; Berthoin, Serge; Feelish, Martin; Roustit, Mathieu; Boissiere, Julien; Fontaine, Pierre; Heyman, Elsa, HE Bruxelles Brabant
      Article scientifique
      Background: A large yet heterogeneous body of literature exists suggesting that endothelial dysfunction appears early in type 1 diabetes, due to hyperglycemia-induced oxidative stress. The latter may also affect vascular smooth muscles (VSM) function, a layer albeit less frequently considered in that pathology. This meta-analysis aims at evaluating the extent, and the contributing risk factors, of ...

    • One-week cocoa flavanol intake increases prefrontal cortex oxygenation at rest and during moderate-intensity exercise in normoxia and hypoxiaPeer reviewedOpen access 

      12 juillet 2018, Decroix, Lieselot; Tonoli, Cajsa; Lespagnol, Elodie; BALESTRA, Costantino; Descat, Amandine; Drittij-Reijnders, Marie José; Blackwell, Jamie; Stahl, Wilhelm; Jones, Andrew; Wesseler, Antje; Bast, Aalt; Meeusen, Romain; Heyman, Elsa, HE Bruxelles Brabant
      Article scientifique
      During exercise in hypoxia, O2 delivery to brain and muscle is compromised, and oxidative stress is elicited. Cocoa flavanols (CF) have antioxidant capacities and can increase blood flow by stimulating endothelial function. We aimed to examine the effects of 7-day CF intake on oxidative stress, nitric oxide production, and tissue oxygenation in response to exercise in normobaric hypoxia (14.3% O2). ...