• Diving physiopathology: the end of certainties? Food for thoughtPeer reviewedClosed access 

      27 juin 2019, BALESTRA, Costantino; GERMONPRÉ, Peter; Rocco, Monica; Biancofiore, Giovanni; Kot, Jacek, HE Bruxelles Brabant
      Article scientifique
      Our understanding of decompression physiopathology has slowly improved during this last decade and some uncertainties have disappeared. A better understanding of anatomy and functional aspects of Patent Foramen Ovale (PFO) have slowly resulted in a more liberal approach toward the medical fitness to dive for those bearing a PFO. Circulating vascular gas emboli (VGE) are considered the key actors in ...
    • Inert gas narcosis in scuba diving, different gases different reactionsPeer reviewedClosed access 

      19 avril 2019, Rocco, Monica; Pelaia, Paolo; Di Benedetto, Pia; Conte, Giuseppe; Maggi, Luigi; Fiorelli, Silvia; Mercieri, Marco; BALESTRA, Costantino; de Biasi, Roberto Alberto, HE Bruxelles Brabant
      Article scientifique
      Purpose Underwater divers face several potential neurological hazards when breathing compressed gas mixtures including nitrogen narcosis which can impact diver’s safety. Various human studies have clearly demonstrated brain impairment due to nitrogen narcosis in divers at 4 ATA using critical flicker fusion frequency (CFFF) as a cortical performance indicator. However, recently some authors have ...
    • The "normobaric oxygen paradox": a new tool for the anesthetist?Peer reviewedOpen access 

      10 janvier 2014, Rocco, Monica; Ditri, Luciano; De Bels, David; Corazza, Francis; BALESTRA, Costantino, HE Bruxelles Brabant
      Article scientifique
      Hypoxia is the natural trigger for endogenous EPO production but recently the use of intermittent hyperoxia to stimulate EPO has been postulated and this phenomenon has been called the "normobaric oxygen paradox" (NOP). The "NOP" is a mechanism by which oxygen regulates the expression of the Hypoxia Inducible Factor 1 alpha (HIF-1alpha). The HIF-1alpha-depending gene regulation is responsible for ...
    • The Normobaric Oxygen Paradox-Hyperoxic Hypoxic Paradox: A Novel Expedient Strategy in Hematopoiesis Clinical IssuesPeer reviewedOpen access 

      janvier 2023, Salvagno, Michele; Coppalini, Giacomo; Taccone, Fabio-Silvio; Strapazzon, Giacomo; Mrakic-Sposta, Simona; Rocco, Monica; Khalife, Maher; BALESTRA, Costantino, HE Bruxelles Brabant
      Article scientifique
      Hypoxia, even at non-lethal levels, is one of the most stressful events for all aerobic organisms as it significantly affects a wide spectrum of physiological functions and energy production. Aerobic organisms activate countless molecular responses directed to respond at cellular, tissue, organ, and whole-body levels to cope with oxygen shortage allowing survival, including enhanced neo-angiogenesis ...