• Intrathoracic pressure changes after Valsalva strain and other maneuvers: implications for divers with patent foramen ovale.Peer reviewedOpen access 

      janvier 1998, GERMONPRÉ, Peter; Marroni A; BALESTRA, Costantinoorcid-id, HE Bruxelles Brabant
      Article scientifique
      Scuba divers with patent foramen ovale (PFO) may be at risk for paradoxical nitrogen gas emboli when performing maneuvers that cause a rebound blood loading to the right atrium. We measured the rise and fall in intrathoracic pressure (ITP) during various maneuvers in 15 divers. The tests were standard isometric exercises (control), forceful coughing, knee bend (with and without respiration blocked), ...
    • Mini Trampoline, a New and Promising Way of SCUBA Diving Preconditioning to Reduce Vascular Gas Emboli?Peer reviewedOpen access 

      29 avril 2022, LAMBRECHTS, Kate; GERMONPRÉ, Peter; Vandenheede, Joaquim; Delorme, Manon; Lafere, Pierre; BALESTRA, Costantinoorcid-id, HE Bruxelles Brabant
      Article scientifique
      Background: Despite evolution in decompression algorithms, decompression illness is still an issue nowadays. Reducing vascular gas emboli (VGE) production or preserving endothelial function by other means such as diving preconditioning is of great interest. Several methods have been tried, either mechanical, cardiovascular, desaturation aimed or biochemical, with encouraging results. In this study, ...
    • Nitric oxide-related endothelial changes in breath-hold and scuba diversPeer reviewedClosed access 

      01 mars 2013, THEUNISSEN, Sigrid; Guerrero, François; Sponciello, Nicholas; Cialoni, Danilo; Pieri, Massimo; GERMONPRÉ, Peter; Obeid, Georges; Tillmans, Frauke; Papadopoulou, Virginie; HEMELRYCK, Walter; Marroni, Alessandro; De Bels, David; BALESTRA, Costantinoorcid-id, HE Bruxelles Brabant
      Article scientifique
      Objective: Scuba and breath-hold divers are compared to investigate whether endothelial response changes are similar despite different exposure(s) to hyperoxia. Design: 14 divers (nine scuba and five breath-holding) performed either one scuba dive (25m/25 minutes) or successive breath-hold dives at a depth of 20 meters, adding up to 25 minutes of immersion time in a diving pool. Flow-mediated ...
    • Normobaric oxygen can enhance protein captation by the lymphatic system in healthy humans.Peer reviewedOpen access 

      janvier 2004, BALESTRA, Costantinoorcid-id; GERMONPRÉ, Peter; SNOECK, Thyl; Ezquer M; LEDUC, Olivier; Leduc A; Willeput F; Marroni A; Cali Corleo R; Vann R, HE Bruxelles Brabant
      Article scientifique
      has been advocated for a long time. Several beneficial effects of NBO have been demonstrated, one of which is the faster elimination of tissue nitrogen bubbles. During DCS occurrence, a cascade of intravascular reactions has been demonstrated. These inflammatory reactions occur within minutes of the onset of DCS, and involve the precipitation of proteins on the gas-bubble interface, causing a ...
    • The 'normobaric oxygen paradox': does it increase haemoglobin?Peer reviewedClosed access 

      14 juin 2012, De Bels, David; THEUNISSEN, Sigrid; Devriendt, Jacques; GERMONPRÉ, Peter; Lafère, Pierre; Valsamis, Joseph; SNOECK, Thyl; Meeus, Philippe; BALESTRA, Costantinoorcid-id, HE Bruxelles Brabant
      Article scientifique
      Background: A novel approach to increasing erythropoietin (EPO) using oxygen (O2) (the 'normobaric oxygen paradox') has been reported in healthy volunteers. We investigated whether the EPO increase is sufficient to induce erythropoiesis by comparing two protocols of O2 administration. Methods: We compared the effect of daily versus alternate days 100% O2, breathed for 30 minutes, on haemoglobin ...
    • Objective vs. Subjective Evaluation of Cognitive Performance During 0.4-MPa Dives Breathing Air or NitroxPeer reviewedClosed access 

      19 avril 2017, GERMONPRÉ, Peter; BALESTRA, Costantinoorcid-id; Hemelryck, Walter; Buzzacott, Peter; Lafère, Pierre, HE Bruxelles Brabant
      Article scientifique
      BACKGROUND: Divers try to limit risks associated with their sport, for instance by breathing enriched air nitrox (EANx) instead of air. This double blinded, randomized trial was designed to see if the use of EANx could effectively improve cognitive performance while diving. METHODS: Eight volunteers performed two no-decompression dry dives breathing air or EANx for 20 min at 0.4 MPa. Cognitive ...
    • Oxidative stress in breath-hold divers after repetitive divesPeer reviewedClosed access 

      08 juin 2013, THEUNISSEN, Sigrid; Sponciello, Nicholas; Rozloznik, Miroslav; GERMONPRÉ, Peter; Guerrero, François; Cialoni, Danilo; BALESTRA, Costantinoorcid-id, HE Bruxelles Brabant
      Article scientifique
      Introduction: Hyperoxia causes oxidative stress. Breath-hold diving is associated with transient hyperoxia followed by hypoxia and a build-up of carbon dioxide (CO₂), chest-wall compression and significant haemodynamic changes. This study analyses variations in plasma oxidative stress markers after a series of repetitive breath-hold dives. Methods: Thirteen breath-hold divers were asked to perform ...
    • Patent Foramen Ovale (PFO), Personality Traits, and Iterative Decompression Sickness. Retrospective Analysis of 209 CasesPeer reviewedOpen access 

      20 août 2017, Lafère, Pierre; BALESTRA, Costantinoorcid-id; Caers, Dirk; GERMONPRÉ, Peter, HE Bruxelles Brabant
      Article scientifique
      Introduction: There is a need to evaluate the influence of risk factors such as patency of foramen ovale (PFO) or "daredevil" psychological profile on contra-indication policy after a decompression sickness (DCS). Methods: By crossing information obtained from Belgian Hyperbaric Centers, DAN Emergency Hotline, the press, and Internet diving forums, it was possible to be accountable for the majority ...
    • Patent foramen ovale and decompression sickness in sports divers.Peer reviewedOpen access 

      mai 1998, GERMONPRÉ, Peter; Dendale P; Unger P; BALESTRA, Costantinoorcid-id, HE Bruxelles Brabant
      Article scientifique
      Patency of the foramen ovale (PFO) may be a cause of unexplained decompression sickness (DCS) in sports divers. To assess the relationship between PFO and DCS, a case-control study was undertaken in a population of Belgian sports divers. Thirty-seven divers who suffered from neurological DCS were compared with matched control divers who never had DCS. All divers were investigated with transesophageal ...
    • Physiology of deep closed circuit rebreather mixed gas diving: vascular gas emboli and biological changes during a week-long liveaboard safariPeer reviewedOpen access 

      01 mars 2024, BALESTRA, Costantinoorcid-id; Leveque Clément; Mrakic-Sposta Simona; Wauthy Pierre; GERMONPRÉ, Peter; Tillmans Frauke; Guerrero François; Lafere Pierre; Vezzoli Alessandra, HE Bruxelles Brabant
      Article scientifique
      Introduction: Diving decompression theory hypothesizes inflammatory processes as a source of micronuclei which could increase related risks. Therefore, we tested 10 healthy, male divers. They performed 6–8 dives with a maximum of two dives per day at depths ranging from 21 to 122 msw with CCR mixed gas diving. Methods: Post-dive VGE were counted by echocardiography. Saliva and urine samples ...
    • Physiology of repeated mixed gas 100-m wreck dives using a closed-circuit rebreather: a field bubble studyPeer reviewedOpen access 

      28 novembre 2021, BALESTRA, Costantinoorcid-id; Guerrero, François; THEUNISSEN, Sigrid; GERMONPRÉ, Peter; Lafère, Pierre, HE Bruxelles Brabant
      Article scientifique
      Purpose: Data regarding decompression stress after deep closed-circuit rebreather (CCR) dives are scarce. This study aimed to monitor technical divers during a wreck diving expedition and provide an insight in venous gas emboli (VGE) dynamics. Methods: Diving practices of ten technical divers were observed. They performed a series of three consecutive daily dives around 100 m. VGE counts were ...
    • Pre-dive Whole-Body Vibration Better Reduces Decompression-Induced Vascular Gas Emboli than Oxygenation or a Combination of BothPeer reviewedOpen access 

      30 novembre 2016, BALESTRA, Costantinoorcid-id; THEUNISSEN, Sigrid; Papadopoulou, Virginie; Le Mener, Cédric; GERMONPRÉ, Peter; Guerrero, François; Lafère, Pierre, HE Bruxelles Brabant
      Article scientifique
      Purpose: Since non-provocative dive profiles are no guarantor of protection against decompression sickness, novel means including pre-dive "preconditioning" interventions, are proposed for its prevention. This study investigated and compared the effect of pre-dive oxygenation, pre-dive whole body vibration or a combination of both on post-dive bubble formation. Methods: Six healthy volunteers performed ...
    • Preconditioning to Reduce Decompression Stress in Scuba DiversPeer reviewedClosed access 

      18 janvier 2017, GERMONPRÉ, Peter; BALESTRA, Costantinoorcid-id, HE Bruxelles Brabant
      Article scientifique
      BACKGROUND: Using ultrasound imaging, vascular gas emboli (VGE) are observed after asymptomatic scuba dives and are considered a key element in the potential development of decompression sickness (DCS). Diving is also accompanied with vascular dysfunction, as measured by flow-mediated dilation (FMD). Previous studies showed significant intersubject variability to VGE for the same diving exposure and ...
    • Predive sauna and venous gas bubbles upon decompression from 400 kPaPeer reviewedOpen access 

      2008, Blatteau, J.-.É.; Gempp, E.; Mets, T.; GERMONPRÉ, Peter; BALESTRA, Costantinoorcid-id, HE Bruxelles Brabant
      Article scientifique
      INTRODUCTION: This study investigated the influence of a far infrared-ray dry sauna-induced heat exposure before a simulated dive on bubble formation, and examined the concomitant adjustments in hemodynamic parameters. METHODS: There were 16 divers who were compressed in a hyperbaric chamber to 400 kPa (30 msw) for 25 min and decompressed at 100 kPa x min(-1) with a 4-min stop at 130 kPa. Each diver ...
    • Scuba diving can induce stress of the temporomandibular joint leading to headache [1]Peer reviewedOpen access 

      2004, BALESTRA, Costantinoorcid-id; GERMONPRÉ, Peter; Marroni, A.; SNOECK, Thyl, HE Bruxelles Brabant
      Article scientifique
      In ordinary recreational scuba diving, many anatomical parts can be involved in disorders of cranial regions: ears and eyes are involved but also sinuses. Dental problems are generally involved in barotraumas because of bad dental fillings or other matters of interest to the general dental practitioner.1 Very few papers have looked at the articular and periarticular problems of the temporomandibular joint ...
    • Scuba Physiological: Think You Know All About Scuba Medicine? Think again!Peer reviewedOpen access 

      01 décembre 2017, Pridmore, Simon; BALESTRA, Costantinoorcid-id; GERMONPRÉ, Peter, HE Bruxelles Brabant
      Livre/Ouvrage ou monographie
      "This book makes it easy to understand the latest discoveries in diving research. You will enjoy reading about our current understanding of what happens to our bodies when we dive." JP Imbert: Decompression designer and technical diving pioneer "As a doctor with a fair history and understanding of diving medicine and diving physiology I found the book interesting. It's the sort of book I would ...
    • Static Metabolic Bubbles as Precursors of Vascular Gas Emboli During Divers' Decompression: A Hypothesis Explaining Bubbling VariabilityPeer reviewedOpen access 

      30 juillet 2019, Imbert, Jean Pierre; Egi, Salih Murat; GERMONPRÉ, Peter; BALESTRA, Costantinoorcid-id, HE Bruxelles Brabant
      Article scientifique
      Introduction: The risk for decompression sickness (DCS) after hyperbaric exposures (such as SCUBA diving) has been linked to the presence and quantity of vascular gas emboli (VGE) after surfacing from the dive. These VGE can be semi-quantified by ultrasound Doppler and quantified via precordial echocardiography. However, for an identical dive, VGE monitoring of divers shows variations related to ...
    • Ultrasound lung "comets" increase after breath-hold divingPeer reviewedClosed access 

      23 octobre 2010, LAMBRECHTS, Kate; GERMONPRÉ, Peter; Charbel, Brian; Cialoni, Danilo; Musimu, Patrick; Sponsiello, Nicola; Marroni, Alessandro; Pastouret, Fredéric; BALESTRA, Costantinoorcid-id, HE Bruxelles Brabant
      Article scientifique
      The purpose of the study was to analyze the ultrasound lung comets (ULCs) variation, which are a sign of extra-vascular lung water. Forty-two healthy individuals performed breath-hold diving in different conditions: dynamic surface apnea; deep variable-weight apnea and shallow, face immersed without effort (static maximal and non-maximal). The number of ULCs was evaluated by means of an ultrasound ...
    • Varying Oxygen Partial Pressure Elicits Blood-Borne Microparticles Expressing Different Cell-Specific Proteins-Toward a Targeted Use of Oxygen?Peer reviewedOpen access 

      17 juillet 2022, BALESTRA, Costantinoorcid-id; Arya, Awadhesh; Leveque, Clément; Virgili, Fabio; GERMONPRÉ, Peter; LAMBRECHTS, Kate; Lafere, Pierre; Thom, Stephen, HE Bruxelles Brabant
      Article scientifique
      Oxygen is a powerful trigger for cellular reactions, but there are few comparative investigations assessing the effects over a large range of partial pressures. We investigated a metabolic response to single exposures to either normobaric (10%, 15%, 30%, 100%) or hyperbaric (1.4 ATA, 2.5 ATA) oxygen. Forty-eight healthy subjects (32 males/16 females; age: 43.7 +/- 13.4 years, height: 172.7 +/- 10.07 ...