• Correlation between Patent Foramen Ovale, cerebral “lesions” and neuropsychometric testing in experienced sports divers: does diving damage the brain?Peer reviewedOpen access 

      01 juin 2016, BALESTRA, Costantino; Germonpré, Peter, HE Bruxelles Brabant
      Article scientifique
      SCUBA diving exposes divers to decompression sickness (DCS). There has been considerable debate whether divers with a Patent Foramen Ovale of the heart have a higher risk of DCS because of the possible right-to-left shunt of venous decompression bubbles into the arterial circulation. Symptomatic neurological DCS has been shown to cause permanent damage to brain and spinal cord tissue; it has been ...
    • Cutis Marmorata skin decompression sickness is a manifestation of brainstem bubble embolization, not of local skin bubblesPeer reviewedClosed access 

      10 avril 2015, Germonpré, Peter; BALESTRA, Costantino; Obeid, Georges; Chers, Dirk, HE Bruxelles Brabant
      Article scientifique
      "Cutis Marmorata" skin symptoms after diving, most frequently in the form of an itching or painful cutaneous red-bluish discoloration are commonly regarded as a mild form of decompression sickness (DCS), and treated with oxygen inhalation without reverting to hyperbaric recompression treatment. It has been observed that the occurrence of Cutis Marmorata is frequently associated with the presence of ...
    • Do Environmental Conditions Contribute to Narcosis Onset and Symptom Severity?Peer reviewedClosed access 

      14 octobre 2016, Lafère, Pierre; Balestra, Costantino; Hemelryck, Walter; Guerrero, François; Germonpré, Peter, HE Bruxelles Brabant
      Article scientifique
      Although many factors contributing to inert gas narcosis onset and severity have been put forward, the available evidence is not particularly strong. Using objective criteria, we have assessed brain impairment associated with narcosis under various environmental diving conditions. 40 volunteers performed a no-decompression dive (33 m for 20 min) either in a dry chamber, a pool or open sea. They were ...
    • Effects of Acute Hypobaric Hypoxia Exposure on Cardiovascular Function in Unacclimatized Healthy Subjects: A "Rapid Ascent" Hypobaric Chamber StudyPeer reviewedOpen access 

      28 avril 2022, THEUNISSEN, Sigrid; BALESTRA, Costantino; Bolognési, Sébastien; Borgers, Guy; Vissenaeken, Dirk; Obeid, Georges; Germonpré, Peter; Honoré, Patrick M.; De Bels, David, HE Bruxelles Brabant
      Article scientifique
      Background: This study aimed to observe the effects of a fast acute ascent to simulated high altitudes on cardiovascular function both in the main arteries and in peripheral circulation. Methods: We examined 17 healthy volunteers, between 18 and 50 years old, at sea level, at 3842 m of hypobaric hypoxia and after return to sea level. Cardiac output (CO) was measured with Doppler transthoracic ...
    • Full-Face Mask Use during SCUBA Diving Counters Related Oxidative Stress and Endothelial DysfunctionPeer reviewedOpen access 

      15 janvier 2022, Levenez, Morgan; LAMBRECHTS, Kate; Mrakic-Sposta, Simona; Vezzoli, Alessandra; Germonpré, Peter; Pique, Hadrien; Virgili, Fabi; Bosco, Gerardo; Lafere, Pierre; BALESTRA, Costantino, HE Bruxelles Brabant
      Article scientifique
      Impaired flow mediated dilation (FMD), an index of vascular stress, is known after SCUBA diving. This is related to a dysfunction of nitric oxide (NO) availability and a disturbance of the redox status, possibly induced by hyperoxic/hyperbaric gas breathing. SCUBA diving is usually performed with a mask only covering "half face" (HF) and therefore forcing oral breathing. Nasal NO production is ...
    • A fully automated method for late ventricular diastole frame selection in post-dive echocardiography without ECG gatingPeer reviewedOpen access 

      02 mars 2021, Markley, Eric; Le, David; Germonpré, Peter; BALESTRA, Costantino; Tillmans, Frauke; Denoble, Petar; Freiberger, Jake; Moon, Richard; Dayton, Paul; Papadopoulou, Virginie, HE Bruxelles Brabant
      Article scientifique
      Venous gas emboli (VGE) are often quantified as a marker of decompression stress on echocardiograms. Bubble-counting has been proposed as an easy to learn method, but remains time-consuming, rendering large dataset analysis impractical. Computer automation of VGE counting following this method has therefore been suggested as a means to eliminate rater bias and save time. A necessary step for this ...
    • A fully automated method for late ventricular diastole frame selection in post-dive echocardiography without ECG gatingErPeer reviewedOpen access 

      02 mars 2021, Markley, Eric; Germonpré, Peter; BALESTRA, Costantino; Tillmans, Frauke; Denoble, Petar; Freiberger, Jake; Moon, Richard; Dayton, Paul; Papadopoulou, Virginie, HE Bruxelles Brabant
      Article scientifique
      Venous gas emboli (VGE) are often quantified as a marker of decompression stress on echocardiograms. Bubble-counting has been proposed as an easy to learn method, but remains time-consuming, rendering large dataset analysis impractical. Computer automation of VGE counting following this method has therefore been suggested as a means to eliminate rater bias and save time. A necessary step for this ...
    • Oxidative Stress Response Kinetics after 60 Minutes at Different (1.4 ATA and 2.5 ATA) Hyperbaric Hyperoxia ExposuresPeer reviewedOpen access 

      02 août 2023, Leveque, Clément; Mrakic-Sposta, Simona; THEUNISSEN, Sigrid; Germonpré, Peter; LAMBRECHTS, Kate; Vezzoli, Alessandra; Bosco, Gerardo; Levenez, Morgan; Lafère, Pierre; Guerrero, François; BALESTRA, Costantino, HE Bruxelles Brabant
      Article scientifique
      Hyperbaric oxygen therapy (HBOT) is a therapeutical approach based on exposure to pure oxygen in an augmented atmospheric pressure. Although it has been used for years, the exact kinetics of the reactive oxygen species (ROS) between different pressures of hyperbaric oxygen exposure are still not clearly evidenced. In this study, the metabolic responses of hyperbaric hyperoxia exposures for 1 h at ...
    • Oxidative Stress Response Kinetics after 60 Minutes at Different Levels (10% or 15%) of Normobaric Hypoxia ExposurePeer reviewedOpen access 

      15 juin 2023, Leveque, Clément; Mrakic-Sposta, Simona; THEUNISSEN, Sigrid; Germonpré, Peter; LAMBRECHTS, Kate; Vezzoli, Alessandra; Gussoni, Maristella; Levenez, Morgan; Lafère, Pierre; Guerrero, François; BALESTRA, Costantino, HE Bruxelles Brabant
      Article scientifique
      In this study, the metabolic responses of hypoxic breathing for 1 h to inspired fractions of 10% and 15% oxygen were investigated. To this end, 14 healthy nonsmoking subjects (6 females and 8 males, age: 32.2 ± 13.3 years old (mean ± SD), height: 169.1 ± 9.9 cm, and weight: 61.6 ± 16.2 kg) volunteered for the study. Blood samples were taken before, and at 30 min, 2 h, 8 h, 24 h, and 48 h after a 1 ...
    • Oxidative Stress Response’s Kinetics after 60 Minutes at Different (30% or 100%) Normobaric Hyperoxia ExposuresPeer reviewedOpen access 

      30 décembre 2022, Leveque, Clément; Mrakic-Sposta, Simona; Lafère, Pierre; Vezzoli, Alessandra; Germonpré, Peter; Beer, Alexandre; Mievis, Stéphane; Virgili, Fabio; LAMBRECHTS, Kate; THEUNISSEN, Sigrid; Guerrero, François; BALESTRA, Costantino, HE Bruxelles Brabant
      Article scientifique
      Oxygen is a powerful trigger for cellular reactions and is used in many pathologies, including oxidative stress. However, the effects of oxygen over time and at different partial pressures remain poorly understood. In this study, the metabolic responses of normobaric oxygen intake for 1 h to mild (30%) and high (100%) inspired fractions were investigated. Fourteen healthy nonsmoking subjects (7 ...
    • Variability in circulating gas emboli after a same scuba diving exposurePeer reviewedClosed access 

      30 avril 2018, Papadopoulou, Virginie; Germonpré, Peter; Cosgrove, David; Eckersley, Robert; Dayton, Paul; Obeid, Georges; BOUTROS, Antoine; Tang, Meng-Txing; THEUNISSEN, Sigrid; BALESTRA, Costantino, HE Bruxelles Brabant
      Article scientifique
      PURPOSE: A reduction in ambient pressure or decompression from scuba diving can result in ultrasound-detectable venous gas emboli (VGE). These environmental exposures carry a risk of decompression sickness (DCS) which is mitigated by adherence to decompression schedules; however, bubbles are routinely observed for dives well within these limits and significant inter-personal variability in DCS risk ...