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The "ON-OFF" Switching Response of Reactive Oxygen Species in Acute Normobaric Hypoxia: Preliminary Outcome

dc.rights.licenseCC0en_US
dc.contributor.authorBALESTRA, Costantino
dc.contributor.authorMrakic-Sposta, Simona
dc.contributor.authorGussoni, Maristella
dc.contributor.authorMarzorati, Mauro
dc.contributor.authorPorcelli, Simone
dc.contributor.authorBosco, Gerardo
dc.contributor.authorMontorsi, Michela
dc.contributor.authorLafortuna, Claudio
dc.contributor.authorVezzoli, Alessandra
dc.date.accessioned2023-10-09T14:28:06Z
dc.date.available2023-10-09T14:28:06Z
dc.date.issued2023-02-16
dc.identifier.urihttps://luck.synhera.be/handle/123456789/2049
dc.identifier.doi10.3390/ijms24044012en_US
dc.description.abstractExposure to acute normobaric hypoxia (NH) elicits reactive oxygen species (ROS) accumulation, whose production kinetics and oxidative damage were here investigated. Nine subjects were monitored while breathing an NH mixture (0.125 F(I)O(2) in air, about 4100 m) and during recovery with room air. ROS production was assessed by Electron Paramagnetic Resonance in capillary blood. Total antioxidant capacity, lipid peroxidation (TBARS and 8-iso-PFG2alpha), protein oxidation (PC) and DNA oxidation (8-OH-dG) were measured in plasma and/or urine. The ROS production rate (mumol.min(-1)) was monitored (5, 15, 30, 60, 120, 240 and 300 min). A production peak (+50%) was reached at 4 h. The on-transient kinetics, exponentially fitted (t(1/2) = 30 min r(2) = 0.995), were ascribable to the low O(2) tension transition and the mirror-like related SpO(2) decrease: 15 min: -12%; 60 min: -18%. The exposure did not seem to affect the prooxidant/antioxidant balance. Significant increases in PC (+88%) and 8-OH-dG (+67%) at 4 h in TBARS (+33%) one hour after hypoxia offset were also observed. General malaise was described by most of the subjects. Under acute NH, ROS production and oxidative damage resulted in time and SpO(2)-dependent reversible phenomena. The experimental model could be suitable for evaluating the acclimatation level, a key element in the context of mountain rescues in relation to technical/medical workers who have not had enough time for acclimatization-as, for example, during helicopter flights.en_US
dc.description.sponsorshipNoneen_US
dc.language.isoENen_US
dc.publisherMDPIen_US
dc.relation.ispartofInternational Journal of Molecular Scienceen_US
dc.rights.urihttps://www.ncbi.nlm.nih.gov/pubmed/36835421en_US
dc.subjectReactive Oxygen Speciesen_US
dc.subjectHypoxiaen_US
dc.subjectHyperoxiaen_US
dc.subjectHyperbaric Hyperoxiaen_US
dc.titleThe "ON-OFF" Switching Response of Reactive Oxygen Species in Acute Normobaric Hypoxia: Preliminary Outcomeen_US
dc.typeArticle scientifiqueen_US
synhera.classificationSciences de la santé humaineen_US
synhera.institutionHE Bruxelles Brabanten_US
synhera.stakeholders.fundNéanten_US
synhera.cost.total0en_US
synhera.cost.apc2300en_US
synhera.cost.comp0en_US
synhera.cost.acccomp0en_US
dc.description.versionOuien_US
dc.rights.holderAuteursen_US


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