The fractal approach as a tool to understand asymptomatic brain hyperintense MRI signals

Abstract

The prevalence of a Patent Foramen Ovale is described in merely 30% of the asymptomatic population. This patency has been shown to be an increasing risk factor for paradoxical cerebral embolization. Some desaturation or decompression situations in human activities such as scuba diving or altitude flight are prone to provoke embolisations. The association with the presence of a patent Foramen Ovale and the onset of cerebral decompression sickness seems to be presenting an odds ratio value of about 5.1.1 The presence of asymptomatic brain lesion-like "spots" has been investigated in a randomized population of diving individuals (n=42 randomized out of 200). The inclusion criteria were drastic and included: age (less than 41 years of age); diving experience (more than 200 logged dives); no decompression sickness episodes; no contraindications for the MRI examination; and no known central nervous system conditions. Data of the magnetic resonance investigation of the brain has been performed in 42 (diving) volunteers fully informed on the experimental procedures. The statistical comparison (Anova test after Kolmogorov-Smirnov compatibility testing and Neuman–Keuls discriminant post-test) of the fractal dimension obtained by means of the box counting method with the slope analysis (Harfa fractal analysis program). The comparison was performed with known pathological images such as multiple sclerosis (a pathology not emerging from vascular problems), ischemic thrombotic lesions (vascular problem), diver's asymptomatic brain spots, and the arteriography of the internal carotid in non-pathological humans (clearly vascular). The statistical difference (p<0.001) between the vascular related images, as well as the absence of statistical difference (p>0.05) with the non-vascular spots images advocates with a non-vascular origin of the diver's asymptomatic spots and thus the link between the patency of the cardiac Foramen Ovale and the brain "spots" seems not to be as clear as it was believed