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Relationships between plasma lipids, proteins, surface tension and post-dive bubbles

dc.rights.licenseOTHen_US
dc.contributor.authorSchellart, Nico
dc.contributor.authorRozloznik, Miroslav
dc.contributor.authorBALESTRA, Costantino
dc.date.accessioned2021-02-07T10:34:13Z
dc.date.available2021-02-07T10:34:13Z
dc.date.issued2015-02-13
dc.identifier.issn1066-2936en_US
dc.identifier.urihttps://luck.synhera.be/handle/123456789/626
dc.description.abstractDecompression sickness (DCS) in divers is caused by bubbles of inert gas. When DCS occurs, most bubbles can be found in the venous circulation: venous gas emboli (VGE). Bubbles are thought to be stabilized by low molecular weight surfactant reducing the plasma-air surface tension (γ). Proteins may play a role as well. We studied the interrelations between these substances, γ and VGE, measured before and after a dry dive simulation. VGE of 63 dive simulations (21-msw/40-minute profile) of 52 divers was examined 40, 80, 120 and 160 minutes after surfacing (precordial Doppler method) and albumin, total protein, triglycerides, total cholesterol and free fatty acids were determined pre- and post-exposure. To manipulate blood plasma composition, half of the subjects obtained a fat-rich breakfast, while the other half got a fat-poor breakfast pre-dive. Eleven subjects obtained both. VGE scores measured with the precordial Doppler method were transformed to the logarithm of Kisman Integrated Severity Scores. With statistical analysis, including (partial) correlations, it could not be established whether γ as well as VGE scores are related to albumin, total protein or total cholesterol. With triglycerides and fatty acids correlations were also lacking, despite the fact that these compounds varied substantially. The same holds true for the paired differences between the two exposures of the 11 subjects. Moreover, no correlation between surface tension and VGE could be shown. From these findings and some theoretical considerations it seems likely that proteins lower surface tension rather than lipids. Since the findings are not in concordance with the classical surfactant hypothesis, reconsideration seems necessary.en_US
dc.description.sponsorshipNoneen_US
dc.language.isoENen_US
dc.publisherUndersea and Hyperbaric Medical Societyen_US
dc.relation.ispartofUndersea & Hyperbaric Medicineen_US
dc.relation.isreferencedbyhttp://www.ncbi.nlm.nih.gov/pubmed/26094288en_US
dc.rights.urihttps://www.copyright.com/openurl.action?rwr=26&&issn=1066-2936&WT.mc.id=Undersea%20and%20Hyperbaric%20Medical%20Societyen_US
dc.subjectNutritionen_US
dc.subjectFatty acidsen_US
dc.subjectTriglyceridesen_US
dc.titleRelationships between plasma lipids, proteins, surface tension and post-dive bubblesen_US
dc.typeArticle scientifiqueen_US
synhera.classificationSciences de la santé humaineen_US
synhera.institutionHE Bruxelles Brabanten_US
synhera.otherinstitutionAMC Amsterdamen_US
synhera.cost.total0en_US
synhera.cost.apc0en_US
synhera.cost.comp0en_US
synhera.cost.acccomp0en_US
dc.description.versionOuien_US
dc.rights.holderUndersea & Hyperbaric Societyen_US


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