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    • Fluoxetine Protection in Decompression Sickness in Mice is Enhanced by Blocking TREK-1 Potassium Channel with the "spadin" AntidepressantPeer reviewedOpen access 

      16 février 2016, Vallée, Nicolas; LAMBRECHTS, Kate; De Maistre, Sébastien; Royal, Perrine; Mazella, Jean; Borsotto, Marc; Heurteaux, Catherine; Abraini, Jacques; RIsso, Jean-Jacques; Blatteau, Jean-Eric, HE Bruxelles Brabant
      Article scientifique
      In mice, disseminated coagulation, inflammation, and ischemia induce neurological damage that can lead to death. These symptoms result from circulating bubbles generated by a pathogenic decompression. Acute fluoxetine treatment or the presence of the TREK-1 potassium channel increases the survival rate when mice are subjected to an experimental dive/decompression protocol. This is a paradox because ...

    • Fluoxetine stimulates anti-inflammatory IL-10 cytokine production and attenuates sensory deficits in a rat model of decompression sicknessPeer reviewedOpen access 

      22 octobre 2015, Blatteau, Jean-Eric; De Maistre, Sébastien; LAMBRECHTS, Kate; Abraini, Jacques; Risso, Jean-Jacques; Vallée, Nicolas, HE Bruxelles Brabant
      Article scientifique
      Despite "gold standard" hyperbaric oxygen treatment, 30% of patients suffering from neurological decompression sickness still exhibit incomplete recovery, including sensory impairments. Fluoxetine, a well-known antidepressant, is recognized as having anti-inflammatory effects in the setting of cerebral ischemia. In this study, we focused on the assessment of sensory neurological deficits and measurement ...