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    • Effect of splenectomy on platelet activation and decompression sickness outcome in a rat model of decompressionPeer reviewedClosed access 

      01 septembre 2014, LAMBRECHTS, Kate; Pontier, Jean-Michel; Mazur, Aleksandra; Buzzacott, Peter; Goanvec, Christel; Wang, Qiong; Theron, Michaël; Belhomme, Marc; Guerrero, François, HE Bruxelles Brabant
      Article scientifique
      Introduction: Splenic platelets have been recognized to have a greater prothrombotic potential than others platelets. We studied whether platelets released by splenic contraction could influence the severity and outcome of decompression sickness (DCS) and bubble-induced platelet activation. Methods: Sixteen, male Sprague-Dawley rats were randomly assigned to either a control or a splenectomized ...

    • Evidence of Heritable Determinants of Decompression Sickness in RatsPeer reviewedClosed access 

      22 juillet 2017, Lautridou, Jacky; Buzzacott, Peter; Belhomme, Marc; Dugrenot, Emmanuel; Lafère, Pierre; BALESTRA, Costantino; Guerrero, François, HE Bruxelles Brabant
      Article scientifique
      NTRODUCTION: Decompression sickness (DCS) is a complex and poorly understood systemic disease caused by inadequate desaturation following a decrease of ambient pressure. Strong variability between individuals is observed for DCS occurrence. This raises questions concerning factors that may be involved in the inter-individual variability of DCS occurrence. This study aimed to experimentally assess ...

    • Influence of decompression sickness on vasocontraction of isolated rat vesselsPeer reviewedClosed access 

      18 février 2015, Mazur, Aleksandra; LAMBRECHTS, Kate; Wang, Qiong; Belhomme, Marc; Theron, Michaël; Buzzacott, Peter; Guerrero, François, HE Bruxelles Brabant
      Article scientifique
      Studies conducted in divers indicate that endothelium function is impaired following a dive even without decompression sickness (DCS). Our previous experiment conducted on rat isolated vessels showed no differences in endothelium-dependent vasodilation after a simulated dive even in the presence of DCS, while contractile response to phenylephrine was progressively impaired with increased decompression ...

    • Mechanism of action of antiplatelet drugs on decompression sickness in rats: a protective effect of anti-GPIIbIIIa therapyPeer reviewedOpen access 

      15 mai 2015, LAMBRECHTS, Kate; Mazur, Aleksandra; Pontier, Jean-Michel; Theron, Michaël; Buzzacott, Peter; Wang, Qiong; Belhomme, Marc; Guerrero, François, HE Bruxelles Brabant
      Article scientifique
      Literature highlights the involvement of disseminated thrombosis in the pathophysiology of decompression sickness (DCS). We examined the effect of several antithrombotic treatments targeting various pathways on DCS outcome: acetyl salicylate, prasugrel, abciximab, and enoxaparin. Rats were randomly assigned to six groups. Groups 1 and 2 were a control nondiving group (C; n = 10) and a control diving ...

    • Physiological characteristics associated with increased resistance to decompression sickness in male and female ratsPeer reviewedOpen access 

      23 juillet 2020, Lautridou, Jacky; Dugrenot, Emmanuel; Amérand, Aline; Guernec, Anthony; Pichavant-Rafini, Karine; Gouvanec, Christelle; Inizan, Manon; Albacete, Gaelle; Belhomme, Marc; Galinat, Hubert; Lafère, Pierre; BALESTRA, Costantino; Guerrero, François; Moisan, Chistine; Buzzacott, Peter, HE Bruxelles Brabant
      Article scientifique
      Decompression sickness (DCS) is a complex and poorly understood systemic disease with wide inter-individual resistance variability. We selectively bred rats with a 3-fold greater resistance to DCS than standard ones. To investigate possible physiological mechanisms underlying the resistance to DCS, including sex-related differences in these mechanisms, 15 males and 15 females resistant to DCS were ...

    • Venous gas emboli are involved in post-dive macro, but not microvascular dysfunctionPeer reviewedClosed access 

      21 janvier 2017, LAMBRECHTS, Kate; BALESTRA, Costantino; Theron, Michaël; Henckes, Anne; Galinat, Hubert; Mignant, Fanny; Belhomme, Marc; Pontier, Jean-Michel; Guerrero, François, HE Bruxelles Brabant
      Article scientifique
      Purpose: Previous studies have shown vascular dysfunction of main conductance arteries and microvessels after diving. We aim to evaluate the impact of bubble formation on vascular function and haemostasis. To achieve this, we used a vibration preconditioning to influence bubble levels without changing any other parameters linked to the dive. Methods: Twentty-six divers were randomly assigned to ...