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    • The "normobaric oxygen paradox": a new tool for the anesthetist?Peer reviewedOpen access 

      10 janvier 2014, Rocco, Monica; Ditri, Luciano; De Bels, David; Corazza, Francis; BALESTRA, Costantino, HE Bruxelles Brabant
      Article scientifique
      Hypoxia is the natural trigger for endogenous EPO production but recently the use of intermittent hyperoxia to stimulate EPO has been postulated and this phenomenon has been called the "normobaric oxygen paradox" (NOP). The "NOP" is a mechanism by which oxygen regulates the expression of the Hypoxia Inducible Factor 1 alpha (HIF-1alpha). The HIF-1alpha-depending gene regulation is responsible for ...