Parcourir Santé par auteur "Pontier, Jean-Michel"
Voici les éléments 1-6 de 6
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Effect of a single, open-sea, air scuba dive on human micro- and macrovascular function
15 août 2013, HE Bruxelles BrabantArticle scientifiquePurpose: Previous studies have shown that bubble formation induced endothelial damage on conduit arteries. We aim to evaluate the effect of diving on microvascular and macrovascular function. Methods: Nine divers took part in a SCUBA dive at 30 msw (400 kPa), for 30 min of bottom time. Pre- and post-dive, they underwent an assessment of endothelial-dependent (acetylcholine) and endothelial-independent ... -
Effect of decompression-induced bubble formation on highly trained divers microvascular function
07 novembre 2013, HE Bruxelles BrabantArticle scientifiqueWe previously showed microvascular alteration of both endothelium-dependent and -independent reactivity after a single SCUBA dive. We aimed to study mechanisms involved in this postdive vascular dysfunction. Ten divers each completed three protocols: (1) a SCUBA dive at 400 kPa for 30 min; (2) a 41-min duration of seawater surface head immersed finning exercise to determine the effect of immersion ... -
Effect of oxygen-breathing during a decompression-stop on bubble-induced platelet activation after an open-sea air dive: oxygen-stop decompression
29 septembre 2013, HE Bruxelles BrabantArticle scientifiquePurpose: We highlighted a relationship between decompression-induced bubble formation and platelet micro-particle (PMP) release after a scuba air-dive. It is known that decompression protocol using oxygen-stop accelerates the washout of nitrogen loaded in tissues. The aim was to study the effect of oxygen deco-stop on bubble formation and cell-derived MP release. Methods: Healthy experienced ... -
Effect of splenectomy on platelet activation and decompression sickness outcome in a rat model of decompression
01 septembre 2014, HE Bruxelles BrabantArticle scientifiqueIntroduction: Splenic platelets have been recognized to have a greater prothrombotic potential than others platelets. We studied whether platelets released by splenic contraction could influence the severity and outcome of decompression sickness (DCS) and bubble-induced platelet activation. Methods: Sixteen, male Sprague-Dawley rats were randomly assigned to either a control or a splenectomized ... -
Mechanism of action of antiplatelet drugs on decompression sickness in rats: a protective effect of anti-GPIIbIIIa therapy
15 mai 2015, HE Bruxelles BrabantArticle scientifiqueLiterature highlights the involvement of disseminated thrombosis in the pathophysiology of decompression sickness (DCS). We examined the effect of several antithrombotic treatments targeting various pathways on DCS outcome: acetyl salicylate, prasugrel, abciximab, and enoxaparin. Rats were randomly assigned to six groups. Groups 1 and 2 were a control nondiving group (C; n = 10) and a control diving ... -
Venous gas emboli are involved in post-dive macro, but not microvascular dysfunction
21 janvier 2017, HE Bruxelles BrabantArticle scientifiquePurpose: Previous studies have shown vascular dysfunction of main conductance arteries and microvessels after diving. We aim to evaluate the impact of bubble formation on vascular function and haemostasis. To achieve this, we used a vibration preconditioning to influence bubble levels without changing any other parameters linked to the dive. Methods: Twentty-six divers were randomly assigned to ...