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The 'normobaric oxygen paradox': does it increase haemoglobin?
14 juin 2012, De Bels, David; THEUNISSEN, Sigrid; Devriendt, Jacques; GERMONPRÉ, Peter; Lafère, Pierre; Valsamis, Joseph; SNOECK, Thyl; Meeus, Philippe; BALESTRA, Costantino, HE Bruxelles BrabantArticle scientifiqueBackground: A novel approach to increasing erythropoietin (EPO) using oxygen (O2) (the 'normobaric oxygen paradox') has been reported in healthy volunteers. We investigated whether the EPO increase is sufficient to induce erythropoiesis by comparing two protocols of O2 administration. Methods: We compared the effect of daily versus alternate days 100% O2, breathed for 30 minutes, on haemoglobin ... -
Physiological and Clinical Impact of Repeated Inhaled Oxygen Variation on Erythropoietin Levels in Patients After Surgery
15 septembre 2021, Khalifé, Maher; Ben Haziz, Mohamed; BALESTRA, Costantino; Valsamis, Joseph; Sosnowski, Maurice, HE Bruxelles BrabantArticle scientifiqueThe "Normobaric Oxygen Paradox" (NOP) is a physiologic mechanism that induces an increase of endogenous erythropoietin (EPO) production by creating a state of relative hypoxia in subjects previously exposed to hyperoxia, followed by a rapid return to normoxia. Oxygen exposure duration and inspired oxygen fraction required to observe a significant increase in EPO or hemoglobin are not clearly defined. ...