Parcourir Santé par auteur "Virgili, Fabio"
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Increasing Oxygen Partial Pressures Induce a Distinct Transcriptional Response in Human PBMC: A Pilot Study on the “Normobaric Oxygen Paradox”
05 janvier 2021, HE Bruxelles BrabantArticle scientifiqueThe term "normobaric oxygen paradox" (NOP), describes the response to the return to normoxia after a hyperoxic event, sensed by tissues as oxygen shortage, and resulting in up-regulation of the Hypoxia-inducible factor 1alpha (HIF-1alpha) transcription factor activity. The molecular characteristics of this response have not been yet fully characterized. Herein, we report the activation time trend ... -
Oxidative Stress Response’s Kinetics after 60 Minutes at Different (30% or 100%) Normobaric Hyperoxia Exposures
30 décembre 2022, HE Bruxelles BrabantArticle scientifiqueOxygen is a powerful trigger for cellular reactions and is used in many pathologies, including oxidative stress. However, the effects of oxygen over time and at different partial pressures remain poorly understood. In this study, the metabolic responses of normobaric oxygen intake for 1 h to mild (30%) and high (100%) inspired fractions were investigated. Fourteen healthy nonsmoking subjects (7 ... -
Oxygen Variations
26 septembre 2023, HE Bruxelles BrabantLivre/Ouvrage ou monographieFor many years, diving and hyperbaric medicine has strived to increase our understanding of the effects of environmental stressors on human pathophysiology. It has demonstrated the importance of oxygen and has taught us not to fear this oxidative molecule, the name of which is derived from the ancient Greek meaning the “acid generator” or Oxy-Gene; indeed, at that time, it was believed that all acids ... -
Oxygen Variations-Insights into Hypoxia, Hyperoxia and Hyperbaric Hyperoxia - Is the Dose the Clue?
20 septembre 2023, HE Bruxelles BrabantArticle scientifiqueon, nitrogen and hydrogen); aerobic organisms depend on it to release energy from carbon-based molecules. The concentration of oxygen in the atmosphere is ~20.93–20.95% (209–460 ppm), but this has fluctuated markedly throughout geological history. It stabilized within a habitable range, between ~15% and 35%, which has been maintained from the Cambrian period 540 million years ago until today [1]. The ... -
A red orange extract modulates the vascular response to a recreational dive: a pilot study on the effect of anthocyanins on the physiological consequences of scuba diving
07 novembre 2015, HE Bruxelles BrabantArticle scientifiqueNutritional antioxidants have been proposed as an expedient strategy to counter the potentially deleterious effects of scuba diving on endothelial function, flow-mediated dilation (FMD) and heart function. Sixteen volunteers performing a single standard dive (20 min at 33 m) according to US Navy diving procedures were randomly assigned to two groups: one was administered with two doses of 200 mg of ... -
Varying Oxygen Partial Pressure Elicits Blood-Borne Microparticles Expressing Different Cell-Specific Proteins-Toward a Targeted Use of Oxygen?
17 juillet 2022, HE Bruxelles BrabantArticle scientifiqueOxygen is a powerful trigger for cellular reactions, but there are few comparative investigations assessing the effects over a large range of partial pressures. We investigated a metabolic response to single exposures to either normobaric (10%, 15%, 30%, 100%) or hyperbaric (1.4 ATA, 2.5 ATA) oxygen. Forty-eight healthy subjects (32 males/16 females; age: 43.7 +/- 13.4 years, height: 172.7 +/- 10.07 ...