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    • Hyperoxia Alters Ultrastructure and Induces Apoptosis in Leukemia Cell LinesPeer reviewedOpen access 

      12 février 2020, De Bels, David; Tillmans, Frauke; Corazza, Francis; Bizzarri, Mariano; GERMONPRÉ, Peter; Radermacher, Peter; Keziban, Gunce-Orman; BALESTRA, Costantinoorcid-id, HE Bruxelles Brabant
      Article scientifique
      Oxygenation conditions are crucial for growth and tumor progression. Recent data suggests a decrease in cancer cell proliferation occurring after exposure to normobaric hyperoxia. Those changes are associated with fractal dimension. The purpose of this research was to study the impact of hyperoxia on apoptosis and morphology of leukemia cell lines. Two hematopoietic lymphoid cancer cell lines (a ...

    • Early Endothelial Dysfunction in Type 1 Diabetes Is Accompanied by an Impairment of Vascular Smooth Muscle Function: A Meta-AnalysisPeer reviewedOpen access 

      05 mai 2020, Lespagnol, Elodie; Dauchet, Luc; Pawlak-Chaouch, Mehdi; BALESTRA, Costantinoorcid-id; Berthoin, Serge; Feelish, Martin; Roustit, Mathieu; Boissiere, Julien; Fontaine, Pierre; Heyman, Elsa, HE Bruxelles Brabant
      Article scientifique
      Background: A large yet heterogeneous body of literature exists suggesting that endothelial dysfunction appears early in type 1 diabetes, due to hyperglycemia-induced oxidative stress. The latter may also affect vascular smooth muscles (VSM) function, a layer albeit less frequently considered in that pathology. This meta-analysis aims at evaluating the extent, and the contributing risk factors, of ...

    • Increasing Oxygen Partial Pressures Induce a Distinct Transcriptional Response in Human PBMC: A Pilot Study on the “Normobaric Oxygen Paradox”Peer reviewedOpen access 

      05 janvier 2021, Fratantonio, Deborah; Virgili, Fabio; Zucchi, Alessandro; LAMBRECHTS, Kate; Latronico, Tiziana; Lafère, Pierre; Germonpré, Pierre; BALESTRA, Costantinoorcid-id, HE Bruxelles Brabant
      Article scientifique
      The term "normobaric oxygen paradox" (NOP), describes the response to the return to normoxia after a hyperoxic event, sensed by tissues as oxygen shortage, and resulting in up-regulation of the Hypoxia-inducible factor 1alpha (HIF-1alpha) transcription factor activity. The molecular characteristics of this response have not been yet fully characterized. Herein, we report the activation time trend ...

    • Investigating critical flicker fusion frequency for monitoring gas narcosis in diversPeer reviewedOpen access 

      17 décembre 2020, Vrijdag, Xavier; Van Waart, Hanna; Sleigh, Jaimie; BALESTRA, Costantinoorcid-id; Mitchell, Simon, HE Bruxelles Brabant
      Article scientifique
      INTRODUCTION: Critical flicker fusion frequency (CFFF) has been used in various studies to measure the cognitive effects of gas mixtures at depth, sometimes with conflicting or apparently paradoxical results. This study aimed to evaluate a novel automatic CFFF method and investigate whether CFFF can be used to monitor gas-induced narcosis in divers. METHODS: Three hyperbaric chamber experiments were ...